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346 results
  • Naratriptan is as effective as sumatriptan for the treatment of migraine attacks when used properly. A mini-review. [Review]
    Cephalalgia. 2021 12; 41(14):1499-1505.Tfelt-Hansen P
  • CONCLUSIONS: Naratriptan was marketed for the treatment of migraine attacks as the "gentle triptan" in a low oral dose of 2.5 mg, a dose with no more adverse events than placebo. This low dose results in the slow onset of action and low efficacy of oral naratriptan, but in high doses oral naratriptan is similar to oral sumatriptan. Based on one randomized controlled trial, subcutaneous naratriptan has probably the greatest effect of any triptan.
  • Drugs and Lactation Database (LactMed): Naratriptan [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • There is minimal published experience with naratriptan during breastfeeding. If naratriptan is required by the mother of an older infant, it is not a reason to discontinue breastfeeding, but until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
  • Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding. [Journal Article]
    Basic Clin Pharmacol Toxicol. 2021 Jun; 128(6):795-804.Amundsen S, Nordeng H, … Spigset O
  • Clinical data on the transfer of triptans into human breast milk remain scarce. In a lactation study including 19 breastfeeding women with migraine, we examined the excretion of six different triptans into milk. Following intake of a single dose, each participant collected seven breast milk samples at predefined intervals up to 24 hours after dose. Triptan concentrations in milk were measured usi…
  • Twenty-five years of triptans - a nationwide population study. [Journal Article]
    Cephalalgia. 2021 07; 41(8):894-904.Davidsson OB, Olofsson IA, … Hansen TF
  • The efficacy of triptans as the main acute treatment strategy for migraine headache at the population-wide level needs to be understood to inform clinical decision-making. We summarise key trends in triptan use using more than 25 years of Danish nationwide data.
  • Acute Treatments for Episodic Migraine [BOOK]
    Acute Treatments for Episodic Migraine. Agency for Healthcare Research and Quality (US): Rockville (MD)Singh RBH, VanderPluym JH, … Wang ZBOOK
  • CONCLUSIONS: A number of acute treatments for episodic migraine exist with varying degrees of evidence for effectiveness and harms. Use of triptans, NSAIDs, antiemetics, dihydroergotamine, CGRP antagonists, and lasmiditan is associated with improved pain and function. The evidence base for many other interventions for acute treatment, including opioids, remains limited.
  • Preparation of Functionalized α,β-Unsaturated Sulfonamides via Olefin Cross-Metathesis. [Journal Article]
    Org Lett. 2020 07 02; 22(13):4970-4973.Woźniak Ł, Rajkiewicz AA, … Grela K
  • The synthesis of functionalized α,β-unsaturated sulfonamides by means of cross-metathesis of vinyl sulfonamides and olefins has been developed. The reaction proceeds smoothly in the presence of Hoveyda-Grubbs catalyst and its nitro analogue, providing a wide range of substituted products. The usefulness of this methodology has been proven in the preparation of new derivatives of biologically acti…
  • Naratriptan in the Prophylactic Treatment of Cluster Headache. [Case Reports]
    Intern Med. 2017 Oct 01; 56(19):2579-2582.Ito Y, Mitsufuji T, … Araki N
  • Objective Naratriptan has been reported to reduce the frequency of cluster headache. The purpose of this study was to determine whether naratriptan is effective as a prophylactic treatment for cluster headache in Japan. Methods We retrospectively reviewed all 43 patients with cluster headache who received preventive treatment with naratriptan from April 2009 to April 2015. The International Class…
  • Preparation and Optimization of Fast Dissolving Film of Naratr iptan Hydrochloride. [Journal Article]
    Recent Pat Drug Deliv Formul. 2017; 11(2):124-131.Krishna KD, Pradip ST, Navin SR
  • Naratriptan is second-generation triptan class of antimigraine drug which selectively bind with 5-HT(1B/1D) receptor. It is widely used to treat the migraine attack due to its better tolerability and lower recurrence rate as compared to other triptans. Despite of the applicability, Naratriptan also have several drawback like slow onset of action and fist pass metabolism which reduce its efficacy.…
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