- Distribution in marine fish and EDI estimation of contaminants of emerging concern by vortex-assisted matrix solid-phase dispersion and HPLC-MS/MS. [Journal Article]Mar Pollut Bull. 2023 Jan 12; 187:114530.MP
- Due to their persistence or continuous discharge, toxic substances are present in the aquatic environment, and can bioaccumulate and biomagnify in the food web, generating a significant ecological risk and a threat to human health. The present study assess the occurrence and tissue (muscle, liver, stomach and gills) distribution of 59 anthropogenic contaminants of emerging concern (CECs) in marin…
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- Supramolecular assembly of benzocaine bearing cyclodextrin cavity via host-guest complexes on polyacrylonitrile as an electrospun nanofiber. [Journal Article]J Pharm Biomed Anal. 2023 Feb 20; 225:115223.JP
- Nanofibers (NFs) can be encapsulated with cyclodextrins (CDs) based host-guest complexes (HCs) in order to enable many biological applications. Here, benzocaine (BNZ) forms HCs with β-cyclodextrin (β-CD) that are co-precipitated and further added to polyacrylonitrile (PAN) solution for making BNZ:β-CD-HCs/PAN NFs material with the aid of electrospinning technique. The marginal increase in absorba…
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- Injectable and topical local anesthetics for acute dental pain: 2 systematic reviews. [Review]J Am Dent Assoc. 2023 01; 154(1):53-64.e14.JA
- Local anesthesia is essential for pain control in dentistry. The authors assessed the comparative effect of local anesthetics on acute dental pain after tooth extraction and in patients with symptomatic irreversible pulpitis.
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- A Case Report of Cyanosis With Refractory Hypoxemia: Is It Methemoglobinemia? [Case Reports]
- Dapsone is used in the treatment of a variety of dermatological conditions and prophylaxis of opportunistic infections. However, if consumed at a dose of more than 200 mg/day, it can cause methemoglobinemia, a condition characterized by elevated methemoglobin levels in the blood; methemoglobin is an abnormal form of hemoglobin, containing iron in the ferric state (Fe3 +) rather than the reduced f…
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- An oligosaccharide marker for rapid authentication of edible bird's nest. [Journal Article]Food Chem. 2023 May 30; 409:135334.FC
- Edible bird's nest (EBN) is a popular and expensive food material. The limited supply and great demand result in the use of adulterants. The authenticity concern is raised due to the lack of appropriate quality markers. Herein, this study aims to provide a specific oligosaccharide marker for rapid EBN authentication. Comparing the benzocaine (ABEE)-labeled saccharide profiles of multiple batches …
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- A novel tDCS control condition using optimized anesthetic gel to block peripheral nerve input. [Journal Article]
- CONCLUSIONS: Topical anesthetics reduce stimulation sensations by blocking peripheral nerve input during tDCS. The BL10 gel tends to work faster and is more electrically stable than EMLA gel.
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- [Possibilities of modern forms of antimicrobial peptides in the treatment of inflammatory pathology of the pharynx]. [Journal Article]Vestn Otorinolaringol. 2022; 87(5):43-49.VO
- Inflammatory diseases of the pharynx occupy one of the leading places in the structure of otorhinolaryngological pathology. Acute and chronic inflammatory processes in the pharynx, as well as exacerbations of the latter, are faced by doctors of a wide range of specialties. Oropharyngeal swab laboratory testing is required to identify a specific pathogen, which takes time. In this regard, of parti…
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- Assessment of Binary Agarose-Carbopol Buccal Gels for Mucoadhesive Drug Delivery: Ex Vivo and In Vivo Characterization. [Journal Article]
- Agarose (AG) is a naturally occurring biocompatible marine seaweed extract that is converted to hydrocolloid gel in hot water with notable gel strength. Currently, its mucoadhesion properties have not been fully explored. Therefore, the main aim of this study was to evaluate the mucoadhesive potential of AG binary dispersions in combination with Carbopol 934P (CP) as mucoadhesive gel preparations…
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- StatPearls: Benzocaine [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- Benzocaine is a local anesthetic used in pain control management, and it is in the ester local anesthetic class of medications. This activity describes the indications, action, and contraindications for benzocaine as a valuable agent in managing pain control. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacod…
- Effects of local anesthetics on compound action potentials generated from the frog sciatic nerve. [Journal Article]Adv Physiol Educ. 2022 Dec 01; 46(4):658-666.AP
- The frog sciatic nerve provides a robust physiological preparation students may conveniently use to investigate the properties of compound action potentials. Electrical stimulation with standard physiology teaching equipment elicits compound action potentials that are easily recorded by upper-level undergraduate students. The amplitude of compound action potentials increases with greater stimulat…
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- Reagentless Voltammetric Identification of Cocaine from Complex Powders. [Journal Article]Anal Chem. 2022 09 20; 94(37):12638-12644.AC
- Cocaine is one of the most commonly trafficked and abused drugs in the United States, and deployable field tests are important for rapid identification in nonlaboratory settings. At present, colorimetric tests exist for in-field determination, but these fundamentally suffer from interferent effects. Cocaine is an organic salt that is readily water soluble as a cation and almost insoluble in the d…
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- In Vitro and In Silico Study to Assess Toxic Mechanisms of Hybrid Molecules of Quinone-Benzocaine as Plastoquinone Analogues in Breast Cancer Cells. [Journal Article]
- We managed to obtain three different series of 2,3-dimethyl-1,4-benzoquinones, named nonhalogenated and halogenated (brominated and chlorinated) PQ analogues, via the molecular hybridization strategy. Sixteen of eighteen hybrid molecules were selected by the National Cancer Institute (NCI) of Bethesda for their in vitro antiproliferative potential against the full NCI 60 cell line panel. The hybr…
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- Evaluating Novel Agarose-Based Buccal Gels Scaffold: Mucoadhesive and Pharmacokinetic Profiling in Healthy Volunteers. [Journal Article]
- Agarose (AG) forms hydrocolloid in hot water and possesses a noteworthy gel strength. However, no reasonable scientific work on investigating the mucoadhesive character of AG has been reported. Therefore, the current study was designed to develop AG and carbopol (CP) based buccal gel scaffold for simultaneous release of benzocaine (BZN) and tibezonium iodide (TIB). Gels' scaffold formulations (F1…
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- A Rare Culprit of Methemoglobinemia. [Case Reports]
- Methemoglobinemia is a rare cause of hypoxia and can be a diagnostic challenge early in the disease course. The incidence of medication-induced methemoglobinemia is more common than congenital-related methemoglobinemia. The most common cause of methemoglobinemia is exposure to household detergents, illicit drugs, or medications with nitrate or sulfonamide chemical groups. The 2 main medications a…
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- Case Report: An Uncommon Etiology of Vulvar Irritation and Swelling in an Adolescent Patient. [Case Reports]J Pediatr Adolesc Gynecol. 2022 Dec; 35(6):715-717.JP
- CONCLUSIONS: This case highlights the potential dangers of off-the-shelf products, such as Vagisil. In patients presenting with vulvovaginal complaints, care providers should carefully screen for use of "hygiene products" as part of exposure history.
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- [Allergy Diagnostics 2021]. [Review]Laryngorhinootologie. 2022 08; 101(8):673-686.L
- Allergic diseases are among the most common diseases worldwide. For appropriate management knowledge of the allergy trigger is crucial. The clinical picture of allergic diseases is diverse and correct diagnosis is often a challenge. The allergist needs to distinguish intolerances from allergies and infectious diseases from non-infectious triggers. Test results have to be interpreted accordingly t…
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- Determination of Benzocaine in Pharmaceutical Formulations by Indirect SERRS Assay Combined with Azo Coupling. [Journal Article]
- Coupled with an azo coupling reaction, a simple, rapid, sensitive, and effective surface-enhanced resonance Raman scattering (SERRS) detection method for benzocaine was developed. In our study, benzocaine which is used clinically as a local anesthetic was derived with p-aminothiophenol into a corresponding azo product within 5 min, resulting in a strong SERRS response with the simple addition of …
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- Contaminants of emerging concern in marine areas: First evidence of UV filters and paraben preservatives in seawater and sediment on the eastern coast of Tunisia. [Journal Article]Environ Pollut. 2022 Sep 15; 309:119749.EP
- UV filters (UVFs) and paraben preservatives (PBs) are widely used components in many personal care products. However, there has been a rising concern for their endocrine-disrupting effects on wildlife once they reach aquatic ecosystems via recreative activities and wastewater treatment plants effluents. This study addresses UVFs and PBs occurrence in seawater and sediment impacted by tourism and …
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- Asymptomatic benzocaine spray-induced methaemoglobinaemia in preoperative sedation for oesophagogastroduodenoscopy. [Case Reports]BMJ Case Rep. 2022 Jun 27; 15(6)BC
- Methaemoglobinaemia is defined as elevated methaemoglobin in the blood which is characterised by conversion of some of the reduced ferrous iron elements [Fe2+] to the oxidised ferric [Fe3+] form which does not have capacity to bind and transport oxygen resulting in functional anaemia. Causes can be genetic mutations or acquired by medications such as dapsone, nitrates or benzocaine. Benzocaine is…
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- Anaesthesia of decapod crustaceans. [Review]
- Decapod crustaceans (crabs, hermit crabs, lobsters, crayfish, shrimps, prawns) are sentient beings, not only responding to noxious stimuli but also being capable of feeling pain, discomfort, and distress. General anaesthesia aims at producing analgesia, immobilization, and unconsciousness, while sedation reduces consciousness, stress, and anxiety, though without analgesia. Anaesthesia is recommen…
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- A Retrospective Study of 23 Cases: Are Lichenoid Lesions of the Labial Mucosa Induced? [Journal Article]
- Background Lichen planus (LP) is a pathology that affects the skin and the mucosa. The lips are rarely involved but represent a diagnostic challenge in those cases. Oral lichenoid lesions (OLL) are defined as lesions that resemble oral lichen planus (OLP) but do not fully meet the clinical and/or histologic criteria for OLP. This study aimed to present our case series and to study the correlation…
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- A Multi-Site Assessment of Anesthetic Overdose, Hypothermic Shock, and Electrical Stunning as Methods of Euthanasia for Zebrafish (Danio rerio) Embryos and Larvae. [Journal Article]
- Euthanasia in zebrafish (Danio rerio) younger than 5 days post fertilization (dpf) is poorly described in the literature, and standardized protocols are lacking, most likely because larvae not capable of independent feeding are often not protected under national legislations. We assessed the euthanasia efficacy in laboratories in different countries of a one hour anesthetic overdose immersion wit…
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- Exploring Potential Regulatory Anesthetic Drugs Based on RNA Binding Protein and Constructing CESC Prognosis Model: A Study Based on TCGA Database. [Journal Article]
- CONCLUSIONS: It is found that different anesthetic drugs have different regulatory effects on the differential expression of RBPs. Based on the differentially expressed RBPs, the prognostic risk score model of CESC patients was constructed. To provide ideas for the formulation of individualized precise anesthesia scheme and cancer pain analgesia scheme, which is helpful to improve the perioperative survival rate of cancer patients.
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- Using Chitosan-Coated Polymeric Nanoparticles-Thermosensitive Hydrogels in association with Limonene as Skin Drug Delivery Strategy. [Journal Article]
- Topical delivery of local anesthetics (LAs) is commonly used to decrease painful sensations, block pain throughout procedures, and alleviate pain after surgery. Dermal and/or transdermal delivery of LAs has other advantages, such as sustained drug delivery and decreased systemic adverse effects. This study reports the development of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles coated with …
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- Portable Raman spectroscopy applied to the study of drugs of abuse. [Journal Article]
- The use of drugs of abuse has grown significantly in recent decades. In forensic chemistry, methods of identifying and characterizing illicit drugs contribute to the interests of researchers, experts, and public security authorities. Among existing methods, portable Raman spectroscopy is notable for performing rapid, non-destructive, and highly selective analysis in the laboratory or on-site. Whe…
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- Benzocaine-induced methaemoglobinaemia in an adolescent with sepsis. [Case Reports]BMJ Case Rep. 2022 Feb 28; 15(2)BC
- Methaemoglobinaemia is a potentially life-threatening condition characterised by hypoxaemia, cyanosis, pallor, fatigue, metabolic acidosis, headache and in severe cases, coma or death. Topical anaesthetics have been reported to cause methaemoglobinaemia. Topical benzocaine was specifically implicated in roughly 66% of anesthetic-induced methaemoglobinaemia cases in a large systematic review in ad…
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- Collision-assisted stripping for determination of microsolvation-dependent protonation sites in hydrated clusters by cryogenic ion trap infrared spectroscopy: the case of benzocaineH+(H2O)n. [Journal Article]Phys Chem Chem Phys. 2022 Mar 09; 24(10):5774-5779.PC
- The protonation site of molecules can be varied by their surrounding environment. Gas-phase studies, including the popular techniques of infrared spectroscopy and ion mobility spectrometry, are a powerful tool for the determination of protonation sites in solvated clusters but often suffer from inherent limits for larger hydrated clusters. Here, we present collision-assisted stripping infrared (C…
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- Highly sensitive determination of anesthetic drug benzocaine based on hydroxypropyl-β-cyclodextrin-carbon black nanohybrids. [Journal Article]Anal Methods. 2022 03 03; 14(9):900-906.AM
- Benzocaine (BZC) is a local anaesthetic drug coupled with numerous adverse effects, and thus poses a great challenge for its simple and highly sensitive detection. For resolving this issue, hydroxypropyl-β-cyclodextrin-carbon black (HP-β-CD-CB) nanohybrid that possesses the collaborative advantages of CB (e.g., excellent electrical properties, large surface area) and HP-β-CD (e.g., high molecule …
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- Evaluating the Preemptive Analgesic Effect of Photo-biomodulation Therapy on Pain Perception During Local Anesthesia Injection in Children: A Split-mouth Triple-blind Randomized Controlled Clinical Trial. [Randomized Controlled Trial]Photochem Photobiol. 2022 09; 98(5):1195-1200.PP
- To evaluate the impact of photobiomodulation therapy (PBMT) on injection pain perception and compare it with a topical oral anesthetic gel. A total of 30 patients of 6 to 9 years-old seeking pulpotomy treatment of maxillary secondary primary molars of both sides were considered for this split-mouth triple-blind randomized clinical trial. On one side of the maxilla, the low-level laser (diode lase…
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- Antibacterial and anticancer profiling of new benzocaine derivatives: Design, synthesis, and molecular mechanism of action. [Journal Article]Arch Pharm (Weinheim). 2022 Apr; 355(4):e2100451.AP
- The need for new chemotherapeutics to overcome development of resistance merits research to discover new agents. Benzocaine derivatives are essential compounds in medicinal chemistry due to their various biological activities including antibacterial and anticancer activities. Therefore, this study focuses on the synthesis of new benzocaine derivatives 3a-e, 6, 7a and 7b, 8, 10-14, and 16a-d and t…
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