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Unbound Medicine.
(American trypanosomiasis)
21,518 results
  • Outbreak of Chagas disease in Brazil: Validation of a molecular diagnostic method. [Journal Article]
    Exp Parasitol. 2023 Jan 30 [Online ahead of print]Costa-Oliveira CND, Paiva-Cavalcanti M, … Lorena VMB
  • Chagas disease (CD), caused by the protozoan Trypanosoma cruzi (T. cruzi), affects millions of people worldwide. Polymerase Chain Reaction (PCR) and real-time quantitative PCR (qPCR) have been used as tools to monitor parasitic levels in the bloodstream of individuals exposed to infection, thus enabling the monitoring of relapses and the effectiveness of therapy, for example. The aim of this stud…
  • Circulation of Vaccine-Derived Rotavirus G1P[8] in a Vulnerable Child Cohort in Rio de Janeiro. [Journal Article]
    Pediatr Infect Dis J. 2022 Nov 29 [Online ahead of print]Cunha DCD, Fuller T, … Brasil P
  • CONCLUSIONS: In vaccinated children, there were no breakthrough infections with G1P[8] RV1 and ADD was rare supporting high vaccine effectiveness. We observed G1P[8] RV1 virus shedding among neonates and infants before the first vaccine dose, providing evidence of transmission of the vaccine strain from immunized children to those who are not yet vaccinated.
  • Plasmodium vivax vaccine: What is the best way to go? [Review]
    Front Immunol. 2022; 13:910236.da Veiga GTS, Moriggi MR, … Albrecht L
  • Malaria is one of the most devastating human infectious diseases caused by Plasmodium spp. parasites. A search for an effective and safe vaccine is the main challenge for its eradication. Plasmodium vivax is the second most prevalent Plasmodium species and the most geographically distributed parasite and has been neglected for decades. This has a massive gap in knowledge and consequently in the d…
  • Structural Insight into Privileged Heterocycles as Anti-Trypanosoma cruzi and brucei Agents. [Journal Article]
    Curr Top Med Chem. 2023 Feb 01 [Online ahead of print]Abbasi Shiran J, Ghanbari M, … Razzaghi-Asl N
  • Trypanosomiasis is caused by parasitic protozoan trypanosomes in vertebrates. T. cruzi and T. brucei are causative agents of Chagas disease (CD) and Human African Trypanosomiasis (HAT), respectively. These life-threatening diseases are a serious threat to public health, with considerable incidence in sub-Saharan African and continental Latin America countries. Although WHO validated mitigated num…
  • Enzymatic synthesis of amlodipine amides and evaluation of their anti-Trypanosoma cruzi activity. [Journal Article]
    Org Biomol Chem. 2023 Jan 26 [Online ahead of print]Elso OG, Bivona AE, … García Liñares G
  • Advancing with our project about the development of new antiparasitic agents, we have enzymatically synthesized a series of amides derived from amlodipine, a calcium channel blocker used as an antihypertensive drug. Through lipase-catalyzed acylation with different carboxylic acids, nineteen amlodipine derivatives were obtained, eighteen of which were new compounds. To optimize the reaction condi…
  • Brain damage serum biomarkers induced by COVID-19 in patients from northeast Brazil. [Journal Article]
    J Neurovirol. 2023 Jan 31 [Online ahead of print]Silva RC, da Rosa MM, … Pitta MGR
  • Neurological symptoms have been often reported in COVID-19 disease. In the present study, we evaluated brain damage associated with the increase of serum levels of neurological biomarkers S100B and neuron-specific enolase (NSE) induced by SARS-CoV-2 infection, in a population from Northeastern Brazil. Thirty-six healthy control (G1) individuals and 141 patients with confirmed COVID-19 were enroll…
  • Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure. [Journal Article]
    ESC Heart Fail. 2023 Jan 30 [Online ahead of print]Zweck E, Karschnia M, … Boege F
  • CONCLUSIONS: GPCR autoantibodies are markedly altered in HF. However, they are correlated poorly or even inversely to haemodynamic, metabolic, and functional markers of disease severity, myocardial histology, and myocardial mitochondrial efficiency. These observations do not hint towards a specific cardio-pathogenic role of GPCR autoantibodies and suggest that further investigations are required before specific therapies directed at GPCR autoantibodies can be clinically tested in non-ischaemic HF.
  • MorphoMacro for in vivo and ex vivo quantitative morphometric analysis of microglia. [Journal Article]
    Methods Cell Biol. 2023; 174:75-92.Melo P, S Silveira M, … Relvas JB
  • Microglia cells dynamically survey the central nervous system microenvironment and, in response to tissue damage inflicted by radiation therapy, disease or infection, undergo morphological and functional changes that culminate in microglia activation. Cell shape transformation can be assessed descriptively or, alternatively, it can be quantified as a continuous variable for parameters including t…
  • Intestinal permeability evaluation in patients with chronic Chagas heart failure. [Journal Article]
    ESC Heart Fail. 2023 Jan 28 [Online ahead of print]Rodrigues AB, da Gama Torres HO, … Botoni FA
  • CONCLUSIONS: The present study could not show a disturbance of the intestinal barrier in CCC patients with LVEF <55%, measured by lactulose/mannitol urinary excretion ratio. Further investigations are needed to verify if in patients with LVEF <40% intestinal permeability is increased.
  • Steroid and triterpenoid compounds with antiparasitic properties. [Journal Article]
    Curr Top Med Chem. 2023 Jan 26 [Online ahead of print]Kuzminac IZ, Savić MP, … Nikolić AR
  • Parasitic diseases affect millions of people and animals, predominantly in the tropics, including visitors to tropical countries and other areas. Efficient and low-cost treatments for infections caused by various parasites are not yet available. Antiparasitic drugs have some drawbacks, such as toxicity and the development of resistance by parasites. This has motivated many researchers to focus on…
  • Genomic surveillance: a potential shortcut for effective Chagas disease management. [Journal Article]
    Mem Inst Oswaldo Cruz. 2023; 117:e220164.de Azevedo SLC, Catanho M, … Galvão TC
  • Chagas disease is an enduring public health issue in many Latin American countries, receiving insufficient investment in research and development. Strategies for disease control and management currently lack efficient pharmaceuticals, commercial diagnostic kits with improved sensitivity, and vaccines. Genetic heterogeneity of Trypanosoma cruzi is a key aspect for novel drug design since pharmacol…
  • Activity of the genus Zanthoxylum against diseases caused by protozoa: A systematic review. [Systematic Review]
    Front Pharmacol. 2022; 13:873208.Correa-Barbosa J, Sodré DF, … Dolabela MF
  • Neglected diseases (NDs) are treated with a less varied range of drugs, with high cost and toxicity, which makes the search for therapeutic alternatives important. In this context, plants, such as those from the genus Zanthoxylum, can be promising due to active substances in their composition. This study evaluates the potential of species from this genus to treat NDs. Initially, a protocol was de…
  • Brain FNDC5/irisin expression in patients and mouse models of major depression. [Journal Article]
    eNeuro. 2023 Jan 25 [Online ahead of print]Lima-Filho R, Fortuna JS, … De Felice FG
  • Major depressive disorder (MDD) is a major cause of disability in adults. MDD is both a co-morbidity and a risk factor for Alzheimer's disease (AD), and regular physical exercise has been associated with reduced incidence and severity of MDD and AD. Irisin is an exercise-induced myokine derived from proteolytic processing of fibronectin type III domain-containing protein 5 (FNDC5). FNDC5/irisin i…
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