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7,211 results
  • Association Between Changes in Timing of Spring Onset and Asthma Hospitalization in Maryland. [Journal Article]
    JAMA Netw Open. 2020 Jul 01; 3(7):e207551.Sapkota A, Dong Y, … Jiang C
  • CONCLUSIONS: These results suggest that ongoing changes in the timing of spring onset, which are related to climate variability and change, are associated with asthma hospitalization. Given the high burden of allergic diseases and the number of individuals sensitized to tree pollen, these findings serve as a wake-up call to public health and medical communities regarding the need to anticipate and adapt to the ongoing changes in the timing and severity of the spring allergy season.
  • An assessment of mutagenicity of chemical substances by (quantitative) structure-activity relationship. [Review]
    Genes Environ. 2020; 42:23.Honma M
  • Currently, there are more than 100,000 industrial chemicals substances produced and present in our living environments. Some of them may have adverse effects on human health. Given the rapid expansion in the number of industrial chemicals, international organizations and regulatory authorities have expressed the need for effective screening tools to promptly and accurately identify chemical subst…
  • Protocols for Fast Simulations of Protein Structure Flexibility Using CABS-Flex and SURPASS. [Journal Article]
    Methods Mol Biol. 2020; 2165:337-353.Badaczewska-Dawid AE, Kolinski A, Kmiecik S
  • Conformational flexibility of protein structures can play an important role in protein function. The flexibility is often studied using computational methods since experimental characterization can be difficult. Depending on protein system size, computational tools may require large computational resources or significant simplifications in the modeled systems to speed up calculations. In this wor…
  • Stabilizing the crystal structures of NaFePO4 with Li substitutions. [Journal Article]
    Phys Chem Chem Phys. 2020 Jul 01; 22(25):13975-13980.Wang R, Wu S, … Ho KM
  • Due to the high cost and insufficient resources of lithium, alternative sodium-ion batteries have been widely investigated for large-scale applications. NaFePO4 has the highest theoretical capacity of 154 mA h g-1 among the iron-based phosphates, which makes it an attractive cathode material for Na-ion batteries. Experimentally, LiFePO4 has been highly successful as a cathode material in Li-ion b…
  • In silico models for genotoxicity and drug regulation. [Journal Article]
    Expert Opin Drug Metab Toxicol. 2020 Jun 28 [Online ahead of print]Benigni R, Bassan A, Pavan M
  • Whereas in the past, (Q)SAR methods have been largely used to support the design of new drugs, in the last few decades, there has been a new interest in its applications for the assessment of drug safety. In particular, the ICH M7 guideline has introduced the concept that (Q)SAR predictions for the Ames mutagenicity of drug impurities can be used for regulatory purposes.
  • Agrodiag PorCoV: A multiplex immunoassay for the differential diagnosis of porcine enteric coronaviruses. [Journal Article]
    J Immunol Methods. 2020 Aug; 483:112808.Malbec R, Kimpston-Burkgren K, … Giménez-Lirola L
  • Three different porcine enteric coronaviruses (PECs), i.e., porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV) and porcine Deltacoronavirus (PDCoV) are currently circulating in U.S. commercial swine herds. Differential diagnosis of PECs relies on laboratory methods. This study describes the development of an ELISA-like multiplex planar immunoassay based on virus-sp…
    J Zoo Wildl Med. 2020 Jun; 51(2):334-349.Hofstetter AR, Van Bonn W, Sacco RE
  • There is an unmet need for specific diagnostics of immune perturbations and inflammation in beluga whale (Delphinapterus leucas) clinical care. Quantitative real-time polymerase chain reaction (qPCR) has been used to measure immunomediator gene transcription in beluga whales. The study hypothesis was that a qPCR-based immunomediator assay would supplement routine clinical data with specific and s…
  • Antiphospholipid Antibodies and Autoimmune Haemolytic Anaemia: A Systematic Review and Meta-Analysis. [Review]
    Int J Mol Sci. 2020 Jun 09; 21(11)Ames PRJ, Bucci MMT, … Gentile F
  • The relationship between antiphospholipid antibodies (aPL) and autoimmune haemolytic anaemia (AIHA) has never been systematically addressed. The aim of this study is to assess the link between aPL and AIHA in adult systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). This study performed an EMBASE/PubMed search from inception to June 2019 and meta-analysis using Peto's odds rat…
  • An in silico map of the SARS-CoV-2 RNA Structurome. [Preprint]
    bioRxiv. 2020 Apr 18Andrews RJ, Peterson JM, … Moss WN
  • SARS-CoV-2 is a positive-sense single-stranded RNA virus that has exploded throughout the global human population. This pandemic coronavirus strain has taken scientists and public health researchers by surprise and knowledge of its basic biology (e.g. structure/function relationships in its genomic, messenger and template RNAs) and modes for therapeutic intervention lag behind that of other human…
  • Lignin lags, leads, or limits the decomposition of litter and soil organic carbon. [Journal Article]
    Ecology. 2020 Jun 07 [Online ahead of print]Hall SJ, Huang W, … Hammel KE
  • Lignin's role in litter and soil organic carbon (SOC) decomposition remains contentious. Lignin decomposition was traditionally thought to increase during mid-stage litter decomposition, when cellulose occlusion by lignin began to limit mass loss. Alternatively, lignin decomposition could be greatest in fresh litter as a consequence of co-metabolism, and lignin might decompose faster than bulk SO…
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