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105 results
  • Radiobiology: Foundation and New Insights in Modeling Brachytherapy Effects. [Journal Article]
    Semin Radiat Oncol 2020; 30(1):4-15Annede Md MSc P, Cosset Md JM, … Chargari C
  • Fundamentals in radiobiology commonly known as the '4R's' concept (ie, reoxygenation, repair, redistribution, and repopulation) have mostly been investigated for external beam radiotherapy. However, these fundamentals can be applied to brachytherapy (BT) by accounting for differences in dose rate, fractionation, and response to immunologic agents for this treatment modality. Many improvements hav…
  • [Reirradiations: Which decision-making criteria?] [Journal Article]
    Cancer Radiother 2019; 23(6-7):526-530Cosset JM, Chargari C, Créhange G
  • The decision to reirradiate a volume which had been previously irradiated remains in 2019 one of the most difficult challenge for a radiation oncologist. Such a decision has to be based on a number of clinical and technological criteria, and the radiation oncologist will have to answer three main questions: i) can the patient clinically tolerate a second irradiation in the same previously irradia…
  • Laser-driven radiation: Biomarkers for molecular imaging of high dose-rate effects. [Review]
    Med Phys 2019; 46(10):e726-e734Asavei T, Bobeica M, … Vasos PR
  • Recently developed short-pulsed laser sources garner high dose-rate beams such as energetic ions and electrons, x rays, and gamma rays. The biological effects of laser-generated ion beams observed in recent studies are different from those triggered by radiation generated using classical accelerators or sources, and this difference can be used to develop new strategies for cancer radiotherapy. Hi…
  • [Which alpha/beta ratio for prostate cancer in 2019?] [Review]
    Cancer Radiother 2019; 23(4):342-345Cosset JM, Chargari C, Créhange G
  • In 1999, Brenner and Hall reported for prostate cancer a very low alpha/beta ratio (1.5Gy). In the following years, this value has been confirmed by a large series of papers, so that this very low alpha/beta ratio became a "dogma", on which a large number of hypofractionated schemes were being built. This was logical, since this very low value strongly suggested a beneficial advantage of hypofrac…
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