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3,244 results
  • 1,2,3-Triazole Derivatives as Novel Antifibrinolytic Drugs. [Journal Article]
    Int J Mol Sci. 2022 Nov 29; 23(23)Bosch-Sanz O, Rabadà Y, … Sánchez-García D
  • Fibrinolysis is a natural process that ensures blood fluidity through the removal of fibrin deposits. However, excessive fibrinolytic activity can lead to complications in different circumstances, such as general surgery or severe trauma. The current antifibrinolytic drugs in the market, aminocaproic acid (EACA) and tranexamic acid (TXA), require high doses repetitively to maintain their therapeu…
  • Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage. [Review]
    Cochrane Database Syst Rev. 2022 11 09; 11:CD001245.Germans MR, Dronkers WJ, … Roos YB
  • CONCLUSIONS: The current evidence does not support the routine use of antifibrinolytic drugs in the treatment of people with aneurysmal subarachnoid haemorrhage. More specifically, early administration with concomitant treatment strategies to prevent delayed cerebral ischaemia does not improve clinical outcome. There is sufficient evidence from multiple randomised controlled trials to incorporate this conclusion in treatment guidelines.
  • StatPearls: Aminocaproic Acid [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)KaseerHayaHUF Health Shands HospitalSanghaviDevangDMayo ClinicBOOK
  • Aminocaproic acid, an antifibrinolytic agent, is a medication used to manage and treat acute bleeding disorders. This activity outlines the indications, mechanism of action, and contraindications for aminocaproic acid as a valuable agent in managing hyperfibrinolysis-induced hemorrhage. This activity will also highlight other key factors, including the adverse event profile, off-label indications…
  • Diagnosis and successful management of an extradural compressive hematoma secondary to diphacinone poisoning in a dog. [Case Reports]
    J Vet Emerg Crit Care (San Antonio). 2023 Jan; 33(1):101-106.Solari FP, Sherman AH, … Walton RA
  • CONCLUSIONS: This is the first reported case of a dog with an extradural hematoma secondary to anticoagulant rodenticide causing spinal cord compression and neurological deficits. Surgical management of this case was successful and resulted in improvement of neurological signs. Extradural hematoma should be considered as a potential location of bleeding in rodenticide toxicity as well as a differential diagnosis in patients with neurological deficits.
  • Ultrasmall polymer-coated cerium oxide nanoparticles as a traumatic brain injury therapy. [Journal Article]
    Nanomedicine. 2022 09; 45:102586.Kang DW, Cha BG, … Lee SH
  • No medication has been approved for secondary injuries after traumatic brain injury (TBI). While free radicals are considered a major mediator of secondary injury, conventional antioxidants only have modest clinical efficacy. Here, we synthesized CX201 consisting of core cerium oxide nanoparticles coated with 6-aminocaproic acid and polyvinylpyrrolidone in aqueous phase. CX201 with 3.49 ± 1.11 nm…
  • Effectiveness and Safety of E-aminocaproic Acid in Overall and Less-Invasive Cardiac Surgeries. [Journal Article]
    J Cardiothorac Vasc Anesth. 2022 10; 36(10):3780-3790.Kelava M, Mehta A, … Blackstone EH
  • CONCLUSIONS: The reduction of postoperative red blood cell requirement observed when analyzing the overall cohort did not translate to less-invasive cardiac surgery in the authors' patient population; however, both overall and less-invasive cohorts had lower requirements for other blood components with E-aminocaproic acid. There was no association with major Society of thoracic surgeons (STS)-defined morbidity and mortality in both groups.
  • Biocatalytic Production of a Nylon 6 Precursor from Caprolactone in Continuous Flow. [Journal Article]
    ChemSusChem. 2022 Aug 19; 15(16):e202200811.Romero-Fernandez M, Heckmann CM, Paradisi F
  • 6-Aminocaproic acid (6ACA) is a key building block and an attractive precursor of caprolactam, which is used to synthesize nylon 6, one of the most common polymers manufactured nowadays. (Bio)-production of platform chemicals from renewable feedstocks is instrumental to tackle climate change and decrease fossil fuel dependence. Here, the cell-free biosynthesis of 6ACA from 6-hydroxycaproic acid w…
  • Cryoprecipitate for Alteplase-Related Hemorrhagic Conversion of Acute Ischemic Stroke. [Journal Article]
    J Pharm Pract. 2022 May 20 [Online ahead of print]Verkerk BS, Lesch C, … Berger K
  • Background: Evidence to support cryoprecipitate for reversal of alteplase-related hemorrhagic conversion of acute ischemic stroke is limited. Guidelines recommend cryoprecipitate as first line treatment, followed by aminocaproic acid as a conditional recommendation with very low-quality evidence. The purpose of this case series was to describe the use of cryoprecipitate for alteplase-related hemo…
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