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Unbound Medicine.
(Amlodipine AND overdose of)
127 results
  • Angiotensin II Use in Treatment of Refractory Shock Due to Benazepril and Amlodipine Toxic Ingestion. [Journal Article]
    J Pharm Pract. 2022 Oct 31 [Online ahead of print]Gutierrez GC, Dayton C, … Varney S
  • CONCLUSIONS: Isolated CCB overdoses have high complication rates and well-established treatments. Therefore, management of CCB and ACEi co-ingestion is typically driven by CCB poisoning algorithm. There are multiple reports of CCB and ACEi co-ingestions causing treatment-refractory shock. Therapeutic options are limited by toxicities and availability of salvage therapies. Ang II is a safe and highly effective option to manage these patients.
  • Acute ischemic optic neuropathy in a case of heroin overdose. [Case Reports]
    Radiol Case Rep. 2022 Oct; 17(10):3950-3954.Lakhani DA, Balar AB, … Khan M
  • Presence of acute optic disc and optic nerve infarction in a young man is uncommon finding. This is most commonly seen in the setting of vasculitis and infection. Ischemic optic neuropathy has been reported with cocaine use, amlodipine and alcohol use. To our knowledge there is no reported case of ischemic optic neuropathy in the setting of heroin / opioid use. MR imaging findings in the setting …
  • Accidental paediatric ingestion of amlodipine after pharmacy dispensing error. [Journal Article]
    Med Leg J. 2022 Aug 21 [Online ahead of print]Shukla A, Rutman M, Moeller J
  • Incorrect dispensing of medications by community pharmacies can lead to accidental poisonings. This may not be considered by emergency medicine physicians in patients describing vague symptoms. We present a case of a paediatric ingestion of amlodipine, resulting from a community pharmacy dispensing error, that was recognized by the child's mother, and consider the liability implications.
  • Use of extracorporeal membrane oxygenation in massive amlodipine overdose. [Case Reports]
    Arch Toxicol. 2022 12; 96(12):3403-3405.Hong IZ, Ng M, … Ponampalam R
  • Calcium-channel blocker overdose can result in profound vasoplegia and cardiogenic shock, which can quickly spiral into multi-organ failure and death. In this case report, we discuss two separate cases of massive amlodipine overdose with polydrug intoxication (Patient A: amlodipine and quetiapine; Patient B: amlodipine, fluoxetine and zopiclone), both of which were complicated by life-threatening…
  • StatPearls: Deadly Single Dose Agents [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)EuwemaMichael S.MSOrange Park Medical CenterSwansonTerrell J.TJOrange Park Medical CenterBOOK
  • Although the basics of evaluating and treating most unknown ingestants are well known, many overdoses require very specific treatment if the patient is to have any chance of survival.[1] Countless studies have been published supporting Dr. Gideon Koren's 1993 landmark article "Medications Which Can Kill a Toddler with One Tablet or Teaspoonful" in the Journal of Toxicology.[2][3][4][5] while each…
  • Single-Pass Albumin Dialysis as Rescue Therapy for Pediatric Calcium Channel Blocker Overdose. [Case Reports]
    J Investig Med High Impact Case Rep. 2022 Jan-Dec; 10:23247096221105251.Essink J, Berg S, … Salomon J
  • Calcium channel blocker ingestions remain one of the leading causes of death related to cardiovascular medication ingestion in both adults and pediatric patients. We report a case of a 17-year-old, 103 kg female presenting after an intentional polypharmacy ingestion, including 500 to 550 mg of amlodipine. She presented with profound vasoplegia and cardiovascular collapse requiring high-dose inotr…
  • Multi-organ dysfunction as a presentation of calcium channel blocker intoxication. [Case Reports]
    BMJ Case Rep. 2022 Jan 17; 15(1)Osman AF, Prasad RM, … O'Brien C
  • SummaryWe report the case of a 73-year-old woman who intentionally ingested 400 mg of amlodipine in a suicidal attempt who initially presented with hypotension which persisted despite aggressive therapy with fluid resuscitation, multiple pressor support, high-dose insulin therapy and calcium infusion. Her haemodynamic instability evolved to include bradycardia requiring atropine and transcutaneou…
  • "Feeling the Blues": A Case of Calcium Channel Blocker Overdose Managed With Methylene Blue. [Case Reports]
    Cureus. 2021 Oct; 13(10):e19114.Pellegrini JR, Munshi R, … Iqbal J
  • Amlodipine is a dihydropyridine calcium channel blocker (CCB) commonly used to treat hypertension. In the United States, approximately 9,500 cases of CCB intoxication due to deliberate or inadvertent overdose were reported to poison centers in 2002. We present a case of a patient who presented with CCB overdose complicated by acute respiratory distress syndrome (ARDS) and recalcitrant shock all o…
  • Refractory Shock from Amlodipine Overdose Overcomed with Hyperinsulinemia. [Case Reports]
    Cardiovasc Toxicol. 2022 01; 22(1):63-66.Koliastasis L, Lampadakis I, … Papaioannou S
  • Intoxication from calcium channel blockers exhibits almost 50% mortality rates. Amlodipine is a long-acting dihydropyridine and inappropriate dosage poses a great threat for profound vasodilation, hypotension, and refractory vasopressor-resistant shock. A 72-year-old woman with unremarkable medical history presented to the emergency department due to amlodipine overdose after a suicide attempt at…
  • Severe Amlodipine Toxicity: A Case Rescued with Extracorporeal Membrane Oxygenation. [Journal Article]
    Indian J Crit Care Med. 2020 May; 24(5):365-366.Sutar A, Venkategowda PM, … Chikkaswamy SB
  • Amlodipine is a widely prescribed drugs for the management of hypertension. Its toxicity is associated with severe myocardial depression and refractory hypotension. We present a case of a 28-year-old female known case of seizure disorder and depression who got admitted to our hospital with a history of consumption of 80 tablets of 5 mg amlodipine (total 400 mg). Patient presented to our hospital …
  • The Efficacy of Albumin Dialysis in the Reversal of Refractory Vasoplegic Shock Due to Amlodipine Toxicity. [Case Reports]
    Crit Care Explor. 2020 Jun; 2(6):e0120.Connor-Schuler RL, Carr JM, … Subramanian RM
  • CONCLUSIONS: These cases demonstrate the safety and efficacy of albumin dialysis in the management of near-fatal calcium channel blocker overdoses related to amlodipine and offer an additional therapeutic option apart from conventional supportive care. Importantly, these cases were not associated with impaired cardiac contractility, thereby making venoarterial extracorporeal membrane oxygenation a less preferable option. Furthermore, this therapeutic benefit of albumin dialysis can potentially be extended to the management of toxicity related to other highly protein-bound drugs and toxins.
  • Persistent Hyperinsulinemia Following High-Dose Insulin Therapy: A Case Report. [Case Reports]
    J Med Toxicol. 2020 10; 16(4):465-469.Corcoran JN, Jacoby KJ, … Cole JB
  • CONCLUSIONS: The kinetics of insulin following discontinuation of high-dose insulin therapy are largely unknown, but supraphysiologic insulin levels persist for some time following therapy; this may allow for simple discontinuation rather than titration of insulin at the end of therapy. Dextrose replacement is frequently needed; although the duration is often difficult to predict, prolonged infusions may not be necessary.
  • Exogenous intoxication by non-prescribed use of vitamin D, a case report. [Case Reports]
    BMC Geriatr. 2020 06 24; 20(1) Paula ALT, Gonzaga WPF, … Markus J
  • CONCLUSIONS: Our report summarizes the possible consequences of using a vitamin compound without supervision of a competent professional, as these substances are mistakenly considered non-toxic. To add, little information is available about the supplements' metabolism and their biological effects. Therefore, It is difficult to diagnose intoxication. This case report shows that even the self-administration of a product designed to bring health benefits can become a risky behavior. These vitamin and mineral supplements are supposed to bring patient empowerment and reduce government spending in health-care, but indeed represent a significant public health concern due to possible overdose and drug interactions.
  • Treatment for beta-blocker poisoning: a systematic review. [Systematic Review]
    Clin Toxicol (Phila). 2020 10; 58(10):943-983.Rotella JA, Greene SL, … Wong A
  • Introduction: Beta-adrenoreceptor antagonist (beta-blocker) poisoning is a common overdose which can lead to significant morbidity and mortality.Objective: To evaluate the effects of treatments for beta-adrenoreceptor antagonist poisoning.Methods: Searches were conducted across MEDLINE (1946-26 November 2019, Ovid); Embase (1974-26 November 2019, Ovid); and the Cochrane Central Register of Contro…
  • The unknown known: non-cardiogenic pulmonary edema in amlodipine poisoning, a cohort study. [Journal Article]
    Clin Toxicol (Phila). 2020 11; 58(11):1042-1049.Lindeman E, Ålebring J, … Nordmark Grass J
  • Context: Amlodipine is the most common calcium channel blocker (CCB) on the Swedish market, and poison center (PC) consultations for amlodipine overdoses are increasing. The clinical picture is dominated by vasodilation with relative preservation of cardiac function. CCBs selectively dilate vessels on the afferent side of the capillary network which, in states of preserved or increased blood flow…
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