- A Propensity Score Matched Cohort Study Identifying an Association of Acne, But Not Oral Antibiotic or Isotretinoin Use, With Risk of Incident Inflammatory Bowel Disease. [Journal Article]J Am Acad Dermatol. 2023 Jan 19 [Online ahead of print]JA
- CONCLUSIONS: This matched cohort study identifies an association between acne and IBD. These data provide further reassurance regarding the use of isotretinoin in the treatment of acne.
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- Prevalence and Self-Medication for Acne among Students of Health-Related Science Colleges at King Saud University in Riyadh Region Saudi Arabia. [Journal Article]
- Background and Objectives: In Saudi Arabia, Acne vulgaris is a very predominant ailment among adolescents, especially female university students, and self-medication has become a trend to manage this condition. To determine the prevalence of Acne vulgaris among health care students and to access the scenario of its self-medication in light of students' knowledge, attitude, and practice towards it…
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- Efficacy of Topical Treatments for the Management of Symptomatic Oral Lichen Planus: A Systematic Review. [Review]
- Oral lichen planus (OLP) is a chronic mucosal inflammatory disease associated with T-cell-mediated immunological dysfunction. Symptomatic OLP is a painful condition, and complete healing is often not achieved. The aim of this systematic review was to assess the effectiveness of topical drugs, medications, and other interventions compared to placebo or to other treatments in pain reduction and cli…
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- How is oral isotretinoin prescribed for the treatment of acne vulgaris? Results from a UK Dermatology Clinical Trials Network (UKDCTN) and British Dermatological Nursing Group (BDNG) survey of health professionals. [Journal Article]Clin Exp Dermatol. 2023 Jan 20; 48(1):20-23.CE
- We undertook a survey of UK healthcare professionals through the UK Dermatology Clinical Trials Network and British Dermatological Nursing Group to understand clinicians' routine practice of prescribing oral isotretinoin for treatment of acne vulgaris. We also wanted to understand clinicians' experiences and views on prescribing low daily dose regimens. Overall, the survey showed that clinicians …
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- 13‑cis‑retinoic acid inhibits the self‑renewal, migration, invasion and adhesion of cholangiocarcinoma cells. [Journal Article]Int J Mol Med. 2023 Mar; 51(3)IJ
- 13‑cis‑retinoic acid (13CRA), a Food and Drug Administration‑approved drug for severe acne, is currently being investigated for its potential use in skin cancer prevention. 13CRA has been reported to exhibit antitumor effects against various types of cancer cells, both in vitro and in vivo. However, to the best of our knowledge, no information is yet available regarding the effects of 13CRA on ch…
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- Acne vulgaris: navigating the NICE recommendations for specialist referral, patient expectations, and the isotretinoin product licence. [Journal Article]Clin Exp Dermatol. 2023 Jan 19 [Online ahead of print]CE
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- Prevalence of adverse events varies with the different oral isotretinoin brands in acne treatment: a retrospective observational study. [Journal Article]Arch Dermatol Res. 2023 Jan 19 [Online ahead of print]AD
- Oral isotretinoin remains the most effective treatment for acne. The aim of this retrospective single-center cohort study was to estimate the prevalence of adverse events with the different oral isotretinoin brands used in acne treatment. The population consisted of all patients who consulted for acne between January 2015 and January 2020. The inclusion criterion was the initiation of treatment w…
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- Therapeutic inertia during isotretinoin treatment of juvenile acne by dermatologists, paediatricians and general practitioners. [Journal Article]Ann Dermatol Venereol. 2023 Jan 13 [Online ahead of print]AD
- CONCLUSIONS: Concerns over the psychiatric consequences of isotretinoin in adolescents, the need for frequent follow-up, and lack of continuing medical education were identified as factors favouring inertia in the initiation of isotretinoin treatment in patients with moderate-to-very severe juvenile acne, particularly among paediatricians and GPs. Potential strategies to overcome these barriers include regular training, simplified recommendations in French, and access to first-time prescription for paediatricians and GPs.
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- Effects of lipid-containing eye drops on the ocular surface and in vivo confocal microscopy findings in patients using systemic isotretinoin. [Journal Article]Cutan Ocul Toxicol. 2023 Jan 22 [Online ahead of print]CO
- CONCLUSIONS: Rohto Dry Aid, with its support of the lipid layer, is an effective and safe treatment agent that can improve both ocular surface and IVCM findings in evaporative dry eye cases with MGD.
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- Early acne scar intervention with 1064 nm picosecond laser in patients receiving oral isotretinoin: a randomized split-face controlled pilot study. [Randomized Controlled Trial]Lasers Med Sci. 2023 Jan 12; 38(1):40.LM
- Early acne scar intervention is important. Oral isotretinoin is widely used in patients with moderate to severe acne. Picosecond laser has shown a promising effect on scar clearance. However, there is a lack of reports on the efficacy and safety of early acne scar management by using 1064-nm picosecond laser in patients receiving low-dose oral isotretinoin. Twenty-four patients with atrophic acne…
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- Clinical Factors Affecting the Effectiveness of 1550-nm Erbium-Doped Fractional Photothermolysis Laser for Individual Atrophic Acne Scar Types. [Journal Article]
- CONCLUSIONS: 1550-nm fractional laser treatment for atrophic acne scars was more effective in patients who were younger and taking isotretinoin concurrently.
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- Vulvar sebaceous hyperplasia - a problematic dermatosis of the vulva. [Journal Article]Ginekol Pol. 2023 Jan 04 [Online ahead of print]GP
- Sebaceous glandular hyperplasia (SGH) is a benign form of skin pathology, occurring in approximately one percent of the population. Risk factors for the SGH include advanced age, male sex, exposure to UV radiation and immunosuppression. The pathogenesis of SGH involves hormonal changes, is also regulated by insulin levels, thyroid stimulating hormone (TSH) and cortisol. SGH manifests itself as so…
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- Clinical practice Guidelines for 5-Aminolevulinic acid photodynamic therapy for acne vulgaris in China. [Review]Photodiagnosis Photodyn Ther. 2022 Dec 30; 41:103261.PP
- A variety of evidence suggest that 5-Aminolevulinic acid-based photodynamic therapy (ALA-PDT) is clinically effective in management of acne vulgaris. Several clinical guidelines for acne recommend PDT as an alternative treatment modality for severe acne. However, there is a lack of detailed clinical guideline for PDT in acne treatment. To propose up-to-date, evidence-based and practical recommend…
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- Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris. [Journal Article]Arch Dermatol Res. 2022 Dec 31 [Online ahead of print]AD
- The transcriptomic regulation induced by isotretinoin (13-cis retinoic acid) is still a matter of debate as short-term exposures of immortalized sebocytes with isotretinoin produced conflicting results. Based on translational evidence, it has been hypothesized that oral isotretinoin treatment upregulates the expression of the transcription factor p53. Twenty-five patients suffering from acne vulg…
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- Isotretinoin and pregnancy termination: an overview. [Letter]Int J Dermatol. 2022 Dec 29 [Online ahead of print]IJ
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- The Safety of Isotretinoin Treatment in Patients with Peanut Allergies. [Journal Article]
- CONCLUSIONS: Isotretinoin use did not result in allergic eruptions in patients with a known peanut allergy, however, more robust clinical studies are needed to confirm the extent of its use in this patient population.
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- Bioanalysis of Endogenous Isotretinoin in Altered and Unaltered Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry Coupled with Electrospray Ionization. [Journal Article]J Chromatogr Sci. 2022 Dec 25 [Online ahead of print]JC
- Bioanalytical method development and validation of endogenous Isotretinoin with Isotretinoin D5 as internal standard was done as per current regulatory guidelines. The method is simple, rugged and sensitive enough to estimate endogenous Isotretinoin using the chromatography-tandem mass spectrometry technique. An alternative approach has been adopted for quantitative analysis of endogenous Isotret…
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- Isotretinoin-induced psychosis in a child on treatment for high-risk neuroblastoma. [Letter]Pediatr Blood Cancer. 2022 Dec 22 [Online ahead of print]PB
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- Evaluation of peripheral lymphocyte subsets in acne vulgaris patients before and after systemic isotretinoin treatment. [Journal Article]
- CONCLUSIONS: NK cell count may be a parameter related to acne severity. Systemic ISO may have an inhibitory effect on naïve T cells. Finally, systemic ISO seems to stimulate mature B-cell proliferation.
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- Isotretinoin and the risk of inflammatory bowel disease and irritable bowel syndrome: A large-scale global study. [Journal Article]J Am Acad Dermatol. 2022 Dec 15 [Online ahead of print]JA
- CONCLUSIONS: Isotretinoin does not confer an elevated risk of Crohn's disease, whilst it might be associated with a slight and transient increase in UC risk.
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- Implications of the Dobbs Decision on Marginalized Populations: Letter in Reply to The Supreme Court abortion ban impact on dermatology. [Letter]J Am Acad Dermatol. 2022 Dec 14 [Online ahead of print]JA
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- Isotretinoin, Vitamin A Supplements, and Unintended Pregnancies in Post Roe v. Wade America. [Editorial]
- Isotretinoin is a potent vitamin A derivative that is used to treat acne. However, despite its utility in dermatologic care, it is also highly teratogenic and can cause severe life-threatening fetal abnormalities in the first trimester of pregnancy. As a result, existing regulations are stringent in order to prevent accidental pregnancies in women taking isotretinoin. In the unlikely case of an u…
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- Reactive perforating collagenosis and systemic lupus erythematosus: A rare case report. [Case Reports]
- CONCLUSIONS: Variable skin rash can mimic systemic lupus erythematosus and vasculitis. Therefore, reactive perforating collagenosis is a skin condition that requires high clinical suspension for diagnosis, and it might be challenging to determine whether it is an association or a complication. Furthermore, the timing of the skin biopsy may be crucial for the diagnosis of reactive perforating collagenosis.
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- Chronic Osteomyelitis of the Cranial Vault in an Adolescent Female: A Case Report. [Case Reports]
- We report an 18-year-old female patient who developed left temporal headache and fever one month after administration of isotretinoin for acne. Imaging studies demonstrated osteolytic change in the left frontal bone, and the lesion showed gadolinium contrast enhancement. Biopsy confirmed the diagnosis of osteomyelitis, and the symptoms improved after 8 months of medication with antibiotics and no…
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- Porokeratosis ptychotropica: a case report. [Case Reports]J Yeungnam Med Sci. 2022 Dec 05 [Online ahead of print]JY
- Porokeratosis ptychotropica is an uncommon form of porokeratosis, which was initially described in 1995. It is clinically characterized by symmetrical reddish to brown-colored hyperkeratotic, verrucous, or psoriasiform plaques on the perianal and gluteal regions. The lesions tend to integrate and expand centrally, with small peripheral satellite lesions. Early skin biopsy and appropriate diagnosi…
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- [Translated article] Oral Supplementation and Systemic Drugs for Skin Aging: A Narrative Review. [Review]Actas Dermosifiliogr. 2022 Dec 01 [Online ahead of print]AD
- Skin aging is influenced by intrinsic and extrinsic factors and involves multiple pathogenic mechanisms. The most widely used treatments are topical products and minimally invasive procedures. Evidence on the benefits of systemic therapy is limited for several reasons: reliance on mostly small and predominantly female samples, short study durations, methodologic heterogeneity, and a lack of conse…
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- Acneiform Eruption Following Elexacaftor-Tezacaftor-Ivacaftor Treatment in Patients With Cystic Fibrosis. [Journal Article]
- CONCLUSIONS: This case series study found that acneiform eruption is an adverse event associated with ELX-TEZ-IVA treatment in patients with cystic fibrosis. Most patients developed mild lesions. However, isotretinoin treatment may be necessary in some patients. The mechanism of ELX-TEZ-IVA-associated acneiform eruption is currently unknown, but the observation of necrotizing infundibular crystalline folliculitis in biopsied patients may guide further exploration.
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- Evaluation of hematological parameters in patients using systemic isotretinoin with diagnosis of acne vulgaris. [Journal Article]J Cosmet Dermatol. 2022 Nov 27 [Online ahead of print]JC
- CONCLUSIONS: There was a decrease in neutrophils and NLR and an increase in platelets during isotretinoin treatment, and these changes were usually mild. However, it would be appropriate to monitor blood counts during treatment in patients with neutropenia or thrombocytosis.
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- Association of psychiatric history with delay in the isotretinoin introduction among patients with severe acne: A French population cohort study. [Letter]J Eur Acad Dermatol Venereol. 2022 Nov 26 [Online ahead of print]JE
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