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Unbound Medicine.
(Amoxapine for depression)
201 results
  • Successful Treatment of Amoxapine-Induced Intractable Seizures With Intravenous Lipid Emulsion. [Journal Article]
    J Emerg Med. 2022 Nov 27 [Online ahead of print]Matsuoka M, Imai T, … Kinoshita K
  • Amoxapine is a second-generation tricyclic antidepressant with a greater seizure risk than other antidepressants. If administered in large amounts, amoxapine can cause severe toxicity and death. Therefore, it is necessary to terminate seizures immediately if amoxapine toxicity occurs. However, intractable seizures often occur in these patients. We describe a case of intractable seizures caused by…
  • StatPearls: Amoxapine [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)AbbasSayedaSAvalon University School of MedicineMarwahaRamanRCase Western Reserve Un/MetroHealth MCBOOK
  • Amoxapine is an FDA-approved drug belonging to the class of second-generation tricyclic dibenzoxazepine antidepressants. Generally, it is reserved for resistant or persistent depression. The goal of this activity is to familiarize practitioners with the proper usage of this drug and recognize the adverse effects of this medication. This activity also explores the roles of a cohesive interprofessi…
  • Interactions of antiepileptic drugs with drugs approved for the treatment of indications other than epilepsy. [Review]
    Expert Rev Clin Pharmacol. 2020 Dec; 13(12):1329-1345.Borowicz-Reutt KK, Czuczwar SJ, Rusek M
  • Introduction: Comorbidities of epilepsy may significantly interfere with its treatment as diseases in the general population are also encountered in epilepsy patients and some of them even more frequently (for instance, depression, anxiety, or heart disease). Obviously, some drugs approved for other than epilepsy indications can modify the anticonvulsant activity of antiepileptics. Areas covered:…
  • Association of sleep among 30 antidepressants: a population-wide adverse drug reaction study, 2004-2019. [Journal Article]
    PeerJ. 2020; 8:e8748.Eugene AR
  • CONCLUSIONS: Among the thirty tested antidepressants, consistent with the original hypothesis, amoxepine has strongest 5-HT2C receptor binding affinity and has the highest reporting odds of somnolence. Atomoxetine, ranked second in reporting odds of somnolence overall, binds to the NET with with the strongest binding affinity among the thirty compounds. Mirtazapine, a tetracyclic antidepressant, was ranked 11th in reporting odds of somnolence and had the strongest H1 receptor binding affinity. This study provides an informative ranking of somnolence among thirty antidepressant compounds with an already wide array of clinical indications as well as provides insight into potential drug repurposing in psychopharmacology.
  • Antidepressants in epilepsy. [Review]
    Neurol Neurochir Pol. 2018 Nov - Dec; 52(6):657-661.Górska N, Słupski J, … Gałuszko-Węgielnik M
  • People with epilepsy (PWE) frequently suffer from comorbid mood and anxiety disorders. Depression is one of the major psychiatric comorbidities having a negative impact on the quality of life in people with epilepsy. A review of the literature indicates that the majority of antidepressant-related seizures have been associated with either ultra-high doses or overdosing and, generally, the risk of …
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Antidepressant Agents [BOOK]
    LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The antidepressants are some of the most commonly prescribed medications in current use. They are also important causes of drug induced liver injury accounting for 2% to 5% of clinically apparent cases. The antidepressants can be grouped into four categories: monamine oxidase inhibitors, tricyclic antidepressants, selective serotonin reuptake inhibitors, and miscellaneous agents. The monamine oxi…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Amoxapine [BOOK]
    LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Amoxapine is a tetracyclic antidepressant used for relief of symptoms of depression caused by either reactive or psychotic depression. Amoxapine has been associated with a low rate of minor serum aminotransferase elevations during treatment and to very rare instances of clinically apparent acute liver injury.
  • Proconvulsant effects of antidepressants - What is the current evidence? [Review]
    Epilepsy Behav. 2016 08; 61:287-291.Johannessen Landmark C, Henning O, Johannessen SI
  • Antidepressant drugs may have proconvulsant effects. Psychiatric comorbidity in epilepsy is common. Prescribers might be reluctant to initiate treatment with antidepressants in fear of seizure aggravation. The purpose of this review was to focus upon the current evidence for proconvulsant effects of antidepressants and possible clinical implications. Most antidepressants are regarded as safe and …
  • Amoxapine as an antipsychotic: comparative study versus haloperidol. [Randomized Controlled Trial]
    J Clin Psychopharmacol. 2007 Dec; 27(6):575-81.Chaudhry IB, Husain N, … Kapur S
  • It has been proposed that the lack of extrapyramidal side effects of atypical antipsychotic drugs is caused by their fast dissociation or low affinity for the D2 receptor or their concomitant high affinity for other receptors, for example, 5HT2 and D4. We noted that amoxapine, an established antidepressant, has affinity for 5HT2 and D2 receptors, and its effects in preclinical model are very simi…
  • A fatal case of amoxapine poisoning under the influence of chronic use of psychotropic drugs. [Case Reports]
    Leg Med (Tokyo). 2007 Mar; 9(2):63-7.Kudo K, Inoue H, … Ikeda N
  • A 43-year-old woman was found dead in a car in the supine position. She had been suffering from depression for 2 years and hesitation wounds on the left forearm and wrist were observed. On microscopic examination, pulmonary congestion and edema were observed with heart failure cells in many alveoli, thereby suggesting not only acute but also chronic heart failure. Drug screening in the blood by g…
  • [Treatment for irritable bowel syndrome--psychotropic drugs, antidepressants and so on]. [Review]
    Nihon Rinsho. 2006 Aug; 64(8):1495-500.Sato M, Murakami M
  • Irritable bowel syndrome (IBS) is a functional disease with good prognosis, which is diagnosed by exclusion of possible causative organic diseases. However, since the patients tend to have strong psychotic symptoms including anxiety, tension, depression, irritation and insomnia, this syndrome has to be elucidated as a psychosomatic disease. Although the symptoms are usually limited to gastrointes…
  • Risperidone in the treatment of psychotic depression. [Clinical Trial]
    Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jun; 30(4):701-7.Goto M, Yoshimura R, … Nakamura J
  • In the preset study, the authors investigated that effects of the antipsychotic drug risperidone on psychotic depression and examined the mechanism of risperidone to ameliorate psychotic depression. Fifteen patients met the DSM-IV criteria for major depressive disorder with psychotic features and the remaining five patients met those for bipolar I disorder (most recent episode depressed) with psy…
  • Submissive behavior in mice as a test for antidepressant drug activity. [Journal Article]
    Pharmacol Biochem Behav. 2005 Oct; 82(2):306-13.Malatynska E, Rapp R, … Tunnicliff G
  • Previously, with the administration of antidepressant drugs, it has been demonstrated that the rat model of clinical depression, known as the reduction of submissive behavior model (RSBM), has considerable validity. The present study is an attempt to extend the model to mice. Several antidepressant drugs as well as a number of non-antidepressant agents were administered to mice that had been iden…
  • Amoxapine as an atypical antipsychotic: a comparative study vs risperidone. [Randomized Controlled Trial]
    Neuropsychopharmacology. 2005 Dec; 30(12):2236-44.Apiquian R, Fresan A, … Kapur S
  • Amoxapine is marketed as an antidepressant. However, its in-vitro profile, receptor occupancy and preclinical effects are very similar to atypical antipsychotics. Amoxapine has also shown efficacy as an atypical antipsychotic in open trials. The objective of this study was to compare the antipsychotic and side effect profile of amoxapine and risperidone in a randomised assignment, standardized do…
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