- A breath-taking DRESS due to amoxicillin-clavulanate presenting as polymorphic eruption of the pregnancy. [Journal Article]
- JEJ Eur Acad Dermatol Venereol 2018 Mar 23
- Drug reaction with eosinophilia and systemic symptoms (DRESS) is a delayed-type drug hypersensitivity reaction with potential life-threatening complications. To our knowledge, DRESS has never been de...
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a delayed-type drug hypersensitivity reaction with potential life-threatening complications. To our knowledge, DRESS has never been described in pregnancy. Here, we report on a pregnant woman presenting with erythematous plaques on the abdomen, developing cardiac tamponade due to eosinophilic perimyocarditis and an interstitial pneumonitis five weeks after exposure to amoxicillin-clavulanate. This article is protected by copyright. All rights reserved.
- Prevalence and antibiotic resistance of bacteria isolated from the cerebrospinal fluid of neurosurgical patients at Peking Union Medical College Hospital. [Journal Article]
- ARAntimicrob Resist Infect Control 2018; 7:41
- CONCLUSIONS: PCNSIs could lead to high mortality. Although the MRCoNS were the predominant organism, the management ofAcinetobacter baumanniiwas a major clinical challenge with few effective antimicrobials in PCNSIs.
- Antibiotic Susceptibility of Non-Cholera Vibrios Isolated from Farmed and Wild Marine Fish (Argyrosomus japonicus), Implications for Public Health. [Journal Article]
- MDMicrob Drug Resist 2018 Mar 22
- This study aimed to evaluate the antibiogram and antibiotic resistance genes (ARGs) of Vibrio isolates recovered from a marine fish (Argyrosomus japonicus) and water samples from two commercial dusky...
This study aimed to evaluate the antibiogram and antibiotic resistance genes (ARGs) of Vibrio isolates recovered from a marine fish (Argyrosomus japonicus) and water samples from two commercial dusky kob aquaculture farms and the Kariega estuary, South Africa, and to evaluate these findings for their public health implications. A total of 277 molecularly confirmed Vibrio isolates consisting of 126 Vibrio fluvialis, 45 Vibrio vulnificus, 30 Vibrio Parahaemolyticus, and 76 vibrios belonging to species of the genus other than Vibrio cholerae were subjected to susceptibility testing to 15 antibiotics by the disc diffusion method. Multiple antibiotic resistance index (MARI) was used to determine the antibiotic resistance-associated health risk, while polymerase chain reaction was used to evaluate the presence of 14 ARGs for nonsusceptible strains. Highest resistances were recorded to amoxicillin (76.2%), ampicillin (67.5%), erythromycin (38.3%), and doxycycline (35.0%), while susceptibilities were highest to gentamicin (100%), followed by norfloxacin (97.8%), florfenicol (90.3%), tetracycline (87.7%), and chloramphenicol (87.4%). We recorded a 58.5% multidrug resistance (resistance to ≥2 antimicrobial classes). MARI did not vary significantly between sites (p > 0.05); however, values of >0.2 were recorded in 40% (108/277) of all strains tested. ARG markers, ampC, blaOXA, tetA, tetM, dfr1, sul1, sul2, ermB, nptII, strA, and SXT integrase, were detected in one or more strains with ermB (82.5%), sul2 (53.8%), strA (44%), dfr1 (42.3%), and tetM (38.3%) being the most abundant. Healthy marine finfish (dusky kob) and their environment can serve as reservoirs for antibiotic resistant vibrios and ARGs, which could be disseminated to humans and other susceptible bacteria and this therefore becomes a public health concern.
- Prevalence and characterisation of shigatoxigenicEscherichia coliisolated from beef cattle fed with prebiotics. [Journal Article]
- IJItal J Food Saf 2017 Oct 20; 6(4):6958
- Ten Holstein Friesian calves were divided into two groups of five: one group was given prebiotics in their food, while the other group served as the control group. Every two weeks from birth up to 18...
Ten Holstein Friesian calves were divided into two groups of five: one group was given prebiotics in their food, while the other group served as the control group. Every two weeks from birth up to 18 months, samples of feces were taken from the rectal ampulla to determine the concentration ofE. coli. At each sampling session, three aliquots per sample were collected. The arithmetic mean was calculated and all values (converted into logs) were analysed with GraphPad InStat for analysis of variance, followed by the Tukey-Kramer test. A total of 69E. colistrains were detected, 29 (42.03%) from treated animals and 40 (57.97%) from the control group. The isolates were analysed by PCR for the presence of thestx-1,stx-2,hlyandeaegenes and by the Kirby Bauer test for susceptibility to the most commonly used antimicrobials in cattle breeding. Hierarchical clustering of the isolates was done using Ward's method. Thirty samples were positive for thestx-1gene, 18 forstx- 2, 12 for bothstx-1andstx-2, 8 forhly, and 10 foreae. 4.3% were resistant to sulfamides, 8.6% to tetracycline, 1.4% to gentamicin, 94.6% to cephalothin, 2.8% to chloramphenicol, 13% to ampicillin, 13% to amoxicillin/clavulanic acid, 7.2% to sulphonamides, 4.3% to ceftriaxone, 5.7% to nalidixic acid, 34.7% to ticarcillin, 88.5% to erythromycin, and 5.7% to streptomycin. The isolates from the samples taken from day 210 to day 300 were grouped into a single cluster. Bacteriological examinations showed a reduction in the concentration ofE. coliin the feces of the treated animals compared to the control group. The presence of strains with shigatoxigenicEscherichia colivirulence profiles and the reduction of these in the treated animal group demonstrated that diet can play an important role in reducingE. coliprevalence in cattle.
- Levofloxacin based vs clarithromycin based sequential therapy inhelicobacter pylorieradication; a randomized clinical trial. [Journal Article]
- GHGastroenterol Hepatol Bed Bench 2018; 11(1):19-26
- CONCLUSIONS: Levofluxacin based sequential therapy was more effective than Clarithromycin based sequential therapy in HP eradication. The suggested Levofluxacin based sequential therapy could be an alternative therapy in area with high clarithromycin resistance. Further studies are needed to confirm these findings.
- Comparison ofHelicobacter pylorieradication regimens in patients with end stage renal disease. [Journal Article]
- GHGastroenterol Hepatol Bed Bench 2018; 11(1):15-19
- CONCLUSIONS: The results showed there was no significant difference between the success rates of HP eradication regimens for ESRD patients. According to approved regimen for 90% eradication rate, with a lower number of medications and given the less risk of side effects and drug interactions, the sequential regimen is the best.
- [Treatment of perineal wounds during the post partum period: evaluation of whether or not antibiotic should be systematically prescribed]. [Journal Article]
- PAPan Afr Med J 2017; 28:144
- CONCLUSIONS: At the end of this study the two treatment protocols were shown to be equivalent. Antibiotics should not be prescribed for perineal wounds in order to contain the healthcare costs.
- In Reply: Synergy between amoxicillin and meropenem/clavulanate in drug-resistant tuberculosis. [Journal Article]
- IJInt J Tuberc Lung Dis 2018 Apr 01; 22(4):465-466
- Low-dose amoxicillin-clavulanate in drug-resistant tuberculosis. [Journal Article]
- IJInt J Tuberc Lung Dis 2018 Apr 01; 22(4):465
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- Inferring the interaction structure of resistance to antimicrobials. [Journal Article]
- PVPrev Vet Med 2018 Apr 01; 152:81-88
- The growth of antimicrobial resistance presents a significant threat to human and animal health. Of particular concern is multi-drug resistance, as this increases the chances an infection will be unt...
The growth of antimicrobial resistance presents a significant threat to human and animal health. Of particular concern is multi-drug resistance, as this increases the chances an infection will be untreatable by any antibiotic. In order to understand multi-drug resistance, it is essential to understand the association between drug resistances. Pairwise associations characterize the connectivity between resistances and are useful in making decisions about courses of treatment, or the design of drug cocktails. Higher-order associations, interactions, which tie together groups of drugs can suggest commonalities in resistance mechanism and lead to their identification. To capture interactions, we apply log-linear models of contingency tables to analyze publically available data on the resistance of Escheresia coli isolated from chicken and turkey meat by the National Antimicrobial Resistance Monitoring System. Standard large sample and conditional exact testing approaches for assessing significance of parameters in these models breakdown due to structured patterns inherent to antimicrobial resistance. To address this, we adopt a Bayesian approach which reveals that E. coli resistance associations can be broken into two subnetworks. The first subnetwork is characterized by a hierarchy of β-lactams which is consistent across the chicken and turkey datasets. Tier one in this hierarchy is a near equivalency between amoxicillin-clavulanic acid, ceftriaxone and cefoxitin. Susceptibility to tier one then implies susceptibility to ceftiofur. The second subnetwork is characterized by more complex interactions between a variety of drug classes that vary between the chicken and turkey datasets.