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18,157 results
  • Perioperative Anaphylaxis Including Kounis Syndrome due to Selective Cefazolin Allergy. [Journal Article]
  • IAInt Arch Allergy Immunol 2018 Jun 18; :1-5
  • Mota I, Gaspar Â, Morais-Almeida M
  • CONCLUSIONS: Cefazolin can be responsible for immediate severe allergic reactions in perioperative setting, including KS. Allergological workup is essential for an accurate diagnosis and to explore cross-reactivity between cefazolin and other beta-lactams. Our experience confirmed that patients with IgE-mediated hypersensitivity reactions to cefazolin can tolerate other beta-lactams. This selective pattern of clinical reactivity may be explained by its particular chemical structure, whose R1 side-chain is different from other beta-lactams.
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