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17,850 results
  • Antibiotics for treating gonorrhoea in pregnancy. [Review]
  • CDCochrane Database Syst Rev 2018 Feb 21; 2:CD011167
  • Comunián-Carrasco G, Peña-Martí GE, Martí-Carvajal AJ
  • CONCLUSIONS: This Cochrane Review found high levels of cure of gonococcal infections in pregnancy with the given antibiotic regimens. However, the evidence in this review is inconclusive as it does not support one particular regimen over another. This conclusion was based on very low-quality evidence (downgraded for poor trial design, imprecision) from two trials (involving 514 women), which we assessed to be at a high risk of bias for a number of domains. The harm profiles of the antibiotic regimes featured in this review remain unknown.High-quality RCTs are needed, with sufficient power to assess the clinical effectiveness and potential harms of antibiotics in pregnant women with gonorrhoea. These should be planned according to Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT),conducted following CONSORT recommendations, and based on Patient-Centered Outcomes Research Institute (PCORI) outcomes.
  • Severe acute malnutrition. [Journal Article]
  • COCurr Opin Clin Nutr Metab Care 2018 Feb 15
  • Nel E
  • CONCLUSIONS: Alternative RUTF may provide a cheaper and more acceptable alternative to standard RUTF in the near future. Further research is needed to understand the implications of fatty acid deficiencies and dysbiosis that occur in malnourished children. Routine antibiotic administration in the appropriate setting is unnecessary.
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