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50,096 results
  • An Interesting Case of Severe Hyponatremia. [Journal Article]
    Am J Forensic Med Pathol. 2023 Jan 30 [Online ahead of print]Persons JE, Stauffer S
  • In this report, we present an unusual and multifactorial case of severe hyponatremia with important clinical implications. The decedent was a 42-year-old woman who was discovered at her place of residence with altered mental status and profuse watery diarrhea. The scene was significant for numerous empty water bottles. She was transported to the emergency department of a local medical center and …
  • Methamphetamine-associated cardiomyopathy: an addiction medicine perspective. [Review]
    Intern Med J. 2023 Jan; 53(1):21-26.Somma V, Osekowski M, … Bonomo Y
  • Methamphetamine-associated cardiomyopathy (MaCM) is an increasingly recognised serious complication from methamphetamine (MA) use. It is characterised as the development of otherwise unexplained heart failure in the context of MA use. MaCM predominantly affects a young and vulnerable population with high morbidity and mortality. It is the second leading cause of mortality in patients with MA use …
  • An unconventional cancer-promoting function of methamphetamine in hepatocellular carcinoma. [Journal Article]
    Life Sci Alliance. 2023 Mar; 6(3)Si Z, Yang G, … Yu L
  • For the past decade, the prevalence and mortality of methamphetamine (METH) use have doubled, suggesting that METH use could be the next substance use crisis worldwide. Ingested METH is transformed into other products in the liver, a major metabolic organ. Studies have revealed that METH causes deleterious inflammatory response, oxidative stress, and extensive DNA damage. These pathological damag…
  • Optogenetic and pharmacological interventions link hypocretin neurons to impulsivity in mice. [Journal Article]
    Commun Biol. 2023 01 19; 6(1):74.Tyree SM, Jennings KJ, … de Lecea L
  • Neurons in the lateral hypothalamus expressing the neuropeptide Hypocretin, also known as orexin, are known critical modulators of arousal stability. However, their role in the different components of the arousal construct such as attention and decision making is poorly understood. Here we study Hypocretin neuronal circuit dynamics during stop action impulsivity in a Go/NoGo task in mice. We show…
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