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Unbound Medicine.
(Amphetamine Salt)
685 results
  • Does Labetalol Trigger False Positive Drug Testing Results? [Journal Article]
    J Addict Med. 2023 Jan 17 [Online ahead of print]Bithi N, Merrigan SD, McMillin GA
  • CONCLUSIONS: In summary, false-positive results can be generated by labetalol when tested by immunoassay, but false-positive results are not expected when testing is performed by highly specific analytical approaches such as LC-MS/MS.
  • Syntaxin 1 Ser14 phosphorylation is required for nonvesicular dopamine release. [Journal Article]
    Sci Adv. 2023 Jan 13; 9(2):eadd8417.Shekar A, Mabry SJ, … Galli A
  • Amphetamine (AMPH) is a psychostimulant that is commonly abused. The stimulant properties of AMPH are associated with its ability to increase dopamine (DA) neurotransmission. This increase is promoted by nonvesicular DA release mediated by reversal of DA transporter (DAT) function. Syntaxin 1 (Stx1) is a SNARE protein that is phosphorylated at Ser14 by casein kinase II. We show that Stx1 phosphor…
  • Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans. [Journal Article]
    JAMA Psychiatry. 2022 Dec 14 [Online ahead of print]Kimbrel NA, Ashley-Koch AE, … Million Veteran Program Suicide Exemplar Workgroup, the International Suicide Genetics Consortium, the Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, and the Veterans Affairs Million Veteran Program
  • CONCLUSIONS: The findings of this analysis may advance understanding of the molecular genetic basis of SITB and provide evidence for ESR1, DRD2, TRAF3, and DCC as cross-ancestry candidate risk genes. More work is needed to replicate these findings and to determine if and how these genes might impact clinical care.
  • Can scene bloodstains be used to quantify drug concentration at the moment of injury? [Journal Article]
    Forensic Sci Int. 2022 Dec; 341:111498.Adamowicz P, Ziora B
  • Blood is the primary material for quantitative toxicological analysis and interpretation of the results. However, in some cases like hit-and-run, it may be collected after a long time since the incident, resulting in the complete elimination or a significant decrease in the concentrations of potentially present drugs. If the suspect was injured and bloodstains were revealed, they can become the b…
  • The Use of Drosophila to Understand Psychostimulant Responses. [Review]
    Biomedicines. 2022 Jan 06; 10(1)Philyaw TJ, Rothenfluh A, Titos I
  • The addictive properties of psychostimulants such as cocaine, amphetamine, methamphetamine, and methylphenidate are based on their ability to increase dopaminergic neurotransmission in the reward system. While cocaine and methamphetamine are predominately used recreationally, amphetamine and methylphenidate also work as effective therapeutics to treat symptoms of disorders including attention def…
  • Microsurgical Excision of Ruptured Lenticulostriate Artery Aneurysm. [Case Reports]
    World Neurosurg. 2022 02; 158:181.Fredrickson VL, Makarenko S, … Couldwell WT
  • Lenticulostriate artery aneurysms are uncommon lesions, usually found in adults after hemorrhage. Despite their challenging location, mortality rates after initial hemorrhage are favorable. Securing the hemorrhage source is critical but may be complicated by lesional compression or thrombosis on posthemorrhage vascular imaging. We present key steps in the diagnosis and surgical management of a ru…
  • The Use and Impact of Cognitive Enhancers among University Students: A Systematic Review. [Review]
    Brain Sci. 2021 Mar 10; 11(3)Sharif S, Guirguis A, … Schifano F
  • CONCLUSIONS: The availability of CEs for non-medical indications in different countries is influenced by a range of factors including legal, social and ethical factors. Considering the risk factors and motivations that encourage university students to use CE drugs, it is essential to raise awareness about CE-related harms, counteract myths regarding "safe" CE use and address cognitive enhancement in an early stage during education as a preventative public health measure.
  • A four-channel paper microfluidic device with gold nanoparticles and aptamers for seized drugs. [Journal Article]
    Anal Biochem. 2020 04 15; 595:113619.Wang L, McCord B
  • In this note we describe a four-channel paper microfluidic device (μPAD) that utilizes gold nanoparticles (AuNPs) as colorimetric sensors and specifically tailored aptamers to capture a set of targeted drugs, including cocaine, codeine and methamphetamine. The design utilizes salt-induced aggregation of AuNPs to produce a color change that indicates the presence of target analytes. In the absence…
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