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(Ampullary carcinoma of small intestine)
825 results
  • Gemcitabine-based chemotherapy for advanced biliary tract carcinomas. [Review]
  • CDCochrane Database Syst Rev 2018 Apr 06; 4:CD011746
  • Abdel-Rahman O, Elsayed Z, Elhalawani H
  • CONCLUSIONS: In adults with advanced biliary tract carcinomas, the effects of gemcitabine or gemcitabine-based chemotherapy are uncertain on mortality and overall response compared with a range of inactive or active controls. The very low certainty of evidence is due to risk of bias, lack of information in the analyses and hence large imprecision, and possible publication bias. The confidence intervals do not rule out meaningful benefits or lack of effect of gemcitabine in all comparisons but one on mortality where gemcitabine plus cisplatin is compared with S-1 plus cisplatin. Gemcitabine-based regimens showed an increase in non-serious adverse events (particularly haematological toxicities). Further randomised clinical trials are mandatory, to further explore the best therapeutic options for adults with advanced biliary tract carcinomas.
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