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36,593 results
  • Cystic lung disease. [Journal Article]
    Radiologia (Engl Ed). 2022 Dec; 64 Suppl 3:265-276.Cabeza Martínez B, Giménez Palleiro A, Mazzini Florindez SP
  • The term cystic lung disease encompasses a heterogeneous group of entities characterised by round lung lesions that correspond to cysts with fine walls, which usually contain air. The differential diagnosis of these lesions can be challenging, requiring both clinical and radiological perspectives. Entities such as pulmonary emphysema and cystic bronchiectasis can simulate cystic disease. High-res…
  • [Rationale and significance of the Italian Network for Cardiac Amyloidosis]. [Journal Article]
    G Ital Cardiol (Rome). 2023 Feb; 24(2):93-98.Sinagra G, Emdin M, … Indolfi C
  • The perspective on amyloidosis has changed deeply over the last 10 years following major advances in diagnosis and treatment options, especially in cardiac amyloidosis. This intrinsically heterogeneous disease exposes to the risk of fragmentation of knowledge and requires the interaction among experts of different specialties and subspecialties. Suspicion of disease, timely recognition and confir…
  • First Norwegian case of hereditary ATTR amyloidosis with a novel transthyretin variant. [Journal Article]
    Scand Cardiovasc J. 2023 Dec; 57(1):2174269.Lyng CS, Gude E, … Knudsen EC
  • An earlier healthy 64-year-old man with previous surgery for bilateral carpal tunnel syndrome (CTS) in his 50s, presented with dyspnoea on exertion. Cardiac amyloidosis was suspected due to "red flag" signs and symptoms. Further investigations with scintigraphy and genetic testing confirmed the diagnosis of hereditary ATTR variant (ATTRv) amyloidosis. This is the first case report of ATTRv amyloi…
  • Renal involvement in familial Mediterranean fever in an Algerian population. [Journal Article]
    Clin Nephrol. 2023 Feb 03 [Online ahead of print]Khellaf G, Benziane A, … Benabadji M
  • The objectives of this study were to investigate the clinical biological and histological renal involvement secondary to familial Mediterranean fever (FMF), the epidemiological data, genetics of our patients and their evolution under treatment. We prospectively studied 58 Algerian patients admitted in our nephrology department from January 2012 to January 2021. The diagnosis of nephropathy was su…
  • Cardiovascular Manifestations in Rheumatoid Arthritis. [Journal Article]
    Cardiol Rev. 2022 Dec 20 [Online ahead of print]Sanghavi N, Ingressia JP, … Wasserman A
  • Rheumatoid arthritis (RA) is a systemic inflammatory disorder that characteristically affects the joints. RA has extra-articular manifestations that can impact multiple organ systems including the heart, lungs, eyes, skin, and brain. Cardiovascular involvement is a leading cause of mortality in RA. Cardiovascular manifestations of RA include accelerated atherosclerosis, heart failure, pericarditi…
  • Inotersen to Treat Polyneuropathy Associated with Hereditary Transthyretin (hATTR) Amyloidosis. [Journal Article]
    Health Psychol Res. 2022; 10(5):67910.Robinson C, Pham C, … Ganti L
  • CONCLUSIONS: hATTR is a rare, progressive, and debilitating disease. Its most common presentation is that of polyneuropathy, and it carries a very poor prognosis and a natural history conveying a median survival of < 12 years. Novel therapeutic options are groundbreaking by providing disease-modifying specific, targeted therapies against TTR production and deposition. The use of RNA interference (RNAi) opens the door to the treatment of hereditary diseases by targeting them at the genetic level.
  • Zinc-Epigallocatechin-3-gallate Network-Coated Nanocomposites against the Pathogenesis of Amyloid-Beta. [Journal Article]
    ACS Appl Mater Interfaces. 2023 Feb 01 [Online ahead of print]Andrikopoulos N, Li Y, … Ke PC
  • The aggregation of amyloid beta (Aβ) is a hallmark of Alzheimer's disease (AD), a major cause of dementia and an unmet challenge in modern medicine. In this study, we constructed a biocompatible metal-phenolic network (MPN) comprising a polyphenol epigallocatechin gallate (EGCG) scaffold coordinated by physiological Zn(II). Upon adsorption onto gold nanoparticles, the MPN@AuNP nanoconstruct elici…
  • Differential effects of DTT on HEWL amyloid fibrillation and fibril morphology at different pH. [Journal Article]
    Biophys Chem. 2023 Jan 25; 294:106962.Mitra A, Mitra A, Sarkar N
  • Proteins can transform from their native state to a state having fibrillar aggregates characterized by cross β sheet structure. The fibrillar aggregates are known as amyloid and have been linked to several disorders. Disulfide bonds in proteins are one of the important factors that determine the propensity of aggregation. Hen Egg White Lysozyme (HEWL) was used by us as a model protein to decipher…
  • Long-term survival in people with transthyretin amyloid cardiomyopathy who took tafamidis: A Plain Language Summary. [Review]
    Future Cardiol. 2023 Jan 30 [Online ahead of print]Elliott P, Drachman BM, … Shah SJ
  • This summary presents the results from an ongoing, long-term extension study that followed an earlier study called ATTR-ACT. People who took part in this extension study and ATTR-ACT have a type of heart disease known as transthyretin amyloid cardiomyopathy (ATTR-CM for short), which causes heart failure and death. In ATTR-ACT, people took either a medicine called tafamidis or a placebo (a pill t…
  • Functional connectivity favors hyperactivity leading to synapse loss in amyloidosis. [Preprint]
    bioRxiv. 2023 Jan 05L'Esperance OJ, McGhee J, … Subramanian J
  • Hyperactivity is observed in early Alzheimer's disease (AD) in multiple brain regions, including the visual cortex. We recently found that the postsynaptic structures favor visual cortex hyperactivity, which disrupts functional connectivity and leads to visual recognition memory deficits in a mouse AD model. It is unclear whether presynaptic structures also favor hyperactivity and whether hyperac…
  • Outcomes in patients with cardiac amyloidosis undergoing heart transplantation: the eurotransplant experience. [Journal Article]
    J Heart Lung Transplant. 2023 Jan 12 [Online ahead of print]Kraus MJ, Smits JM, … Kreusser MM
  • CONCLUSIONS: HTX is a viable treatment option for patients at an advanced stage of cardiac amyloidosis as overall survival after transplantation has improved in the modern age. Patients at a very advanced stage of the disease, indicated by low serum albumin and blood pressure, show worse outcomes following HTX. Optimal timing and careful patient selection may therefore be particularly important to further improve post-HTX survival in amyloidosis patients.
  • Localized Amyloidosis of Bilateral Palatine Tonsils Mimicking Tonsillolithiasis. [Journal Article]
    Ear Nose Throat J. 2023 Jan 29 [Online ahead of print]Lo SW, Hsu CM, … Chang GH
  • A rare disease called localized tonsillar amyloidosis can cause serious problems with airway patency in severe cases. This was the case with an elderly man who experienced difficulty breathing and swallowing due to enlarged palatine tonsils. The physical and imaging findings suggested tonsillolithiasis, and the patient underwent bilateral tonsillectomy. The diagnosis of amyloidosis was confirmed …
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