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3,157 results
  • WADA test for postoperative memory prediction in left TLE. Is it still useful in the 21st century? [Journal Article]
    Clin Neurol Neurosurg. 2022 Dec 29; 225:107580.Bruzsa AK, Walther K, … Schwarz M
  • CONCLUSIONS: The Wada test is no longer necessary as a diagnostic tool for a broad group of patients with temporal lobe epilepsy. However, it can be useful for a subgroup of patients with clinical indicators such as nonspecific or incongruent preoperative verbal and figural memory impairments. In this study, Wada test data about the functional level of the contralateral hemisphere specifically allowed estimation of postoperative figural memory changes.
  • StatPearls: Barbiturates [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)SkibiskiJeanieJMissouri State UniversityAbdijadidSaraSUCLABOOK
  • Barbiturates are a group of sedative-hypnotic medications used for the treatment of seizure disorder, neonatal withdrawal, insomnia, preoperative anxiety, induction of coma for increased intracranial pressure. They are also useful for inducing anesthesia. This activity outlines the indications, mechanism of action, safe administration, adverse effects, contraindications, toxicology, and monitorin…
  • Determination of Barbiturates by Femtosecond Ionization Mass Spectrometry. [Journal Article]
    Anal Chem. 2022 10 25; 94(42):14691-14698.Madunil SL, Imasaka T, Imasaka T
  • Barbiturates are highly susceptible to dissociation in mass spectrometry (MS) because of their long side chains combined with a nonaromatic ring consisting of several carbonyl and amine groups. As a result, they exhibit extensive α-cleavage and subsequent rearrangement, making the identification of these compounds difficult. Although a library of electron ionization MS (EIMS) is available, most b…
  • Metabolic and pharmacological profiling of Penicillium claviforme by a combination of experimental and bioinformatic approaches. [Journal Article]
    Ann Med. 2022 12; 54(1):2102-2114.Ali Shah Z, Khan K, … Rauf A
  • CONCLUSIONS: Metabolic profile of P. claviforme shows the presence of biologically relevant compounds in ethyl acetate extract. In addition, P. claviforme exhibits substantial antioxidant and cytotoxic activities in an in vitro model as well as antinociceptive activity in an in vivo model. The antinociceptive action is also supported by a molecular docking study. This research has opened up new possibilities in the disciplines of mycology, agriculture, and pharmaceutics. Key messagesThe first time explored complete metabolome through GC-MS and LC-MS-QTOF.Both in vivo & in vitro pharmacological investigation of P. claviforme.In silico molecular docking of LC-MS-QTOF metabolites.
  • StatPearls: Barbiturate Toxicity [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)SuddockJolee T.JTUniversity of New MexicoCainMatthew D.MDUn of New Mexico HospitalBOOK
  • Barbiturates are a class of sedative-hypnotic drugs. They are commonly used as antiepileptics (phenobarbital) and for the induction of general anesthesia (thiopental). Some states administer barbiturates for physician-assisted suicide/euthanasia and use them for capital punishment by lethal injection. Their use in clinical practice has largely been replaced by benzodiazepines such as alprazolam, …
  • Electrical Wada for pre-surgical memory testing: a case report. [Case Reports]
    Epileptic Disord. 2022 Apr 01; 24(2):411-416.Kaestner E, Pedersen NP, … Drane DL
  • We report a case study of a surgical candidate, a 51-year-old woman with left temporal lobe epilepsy, who failed a left injection intracarotid amobarbital procedure (e.g., Wada test), scoring 0 of 8 items. This raised concerns for postoperative memory decline. However, the patient was uninterested in a neuromodulatory approach and wished to be reconsidered for surgery. A stereotactic laser amygda…
  • Seizure in Patient with Neurofibromatosis and Amygdala Low-Grade Glioma. [Case Reports]
    World Neurosurg. 2022 01; 157:54-55.Carnevale JA, Goldberg JL, Schwartz T
  • A 31-year-old male with history of bipolar disorder, suicidal attempts requiring inpatient hospitalization, and seizures on antiepileptic medications presented with increasing seizure frequency. He was neurologically intact yet had multiple facial, axillary, and inguinal flat pigmented macules (cafe au lait spots) and ophthalmologic examination with iris hamartomas (Lisch nodules) consistent with…
  • Evaluation of the density spectral array in the Wada test: report of six cases. [Case Reports]
    Braz J Anesthesiol. 2021 May-Jun; 71(3):288-291.Pacreu S, Vilà E, … Fernández-Candil JL
  • Wada test is an invasive procedure used in the preoperative evaluation for epilepsy surgery to determine language lateralization, postoperative risk of amnesia syndrome, and to assess the risk of memory deficits. It involves injection of amobarbital into internal carotid artery of the affected hemisphere followed by the healthy hemisphere to shut down brain function. We performed an observational…
  • A History of Diagnostic Investigations in Epilepsy Surgery. [Review]
    Can J Neurol Sci. 2021 11; 48(6):845-851.Hanjani K, Fatehi M, … Redekop GJ
  • Epilepsy surgery has progressed significantly in the last 150 years. Functional brain maps allowed for the localization of epileptogenic lesions based on seizure patterns, allowing surgeons like McEwan and Horsely to treat epilepsy surgically. Berger's electroencephalogram marked the first modality directly identifying epileptic abnormalities. Penfield and Jasper collaborated, as neurosurgeon and…
  • Utilization of MEG Among the US Epilepsy Centers: A Survey-Based Appraisal. [Multicenter Study]
    J Clin Neurophysiol. 2020 Nov; 37(6):599-605.Bagić AI, Burgess RC
  • CONCLUSIONS: Only the centers with larger surgical volumes incorporate MEG regularly in presurgical evaluation of patients with drug-resistant epilepsy. A reversal of the pervasive underutilization of epilepsy surgery can benefit from MEG, but this requires a sustained concerted promotion by the epilepsy and MEG communities.
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