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3,095 results
  • Intermediary Metabolism and Fatty Acid Oxidation: Novel Targets of Electron Transport Chain Driven Injury During Ischemia and Reperfusion. [Journal Article]
  • AJAm J Physiol Heart Circ Physiol 2017 Dec 29
  • Chen Q, Younus MS, … Lesnefsky EJ
  • CONCLUSIONS: Thus, following IR, not only the ETC, but multiple pathways of intermediary metabolism sustain damage initiated by the ETC. If these damaged mitochondria persist in the myocyte, they remain a potent stimulus for ongoing injury and the transition to cardiomyopathy during prolonged reperfusion. Modulation of ETC function during early reperfusion is a key strategy to preserve mitochondrial metabolism and to decrease persistent mitochondria-driven injury during longer periods of reperfusion that predispose to ventricular dysfunction and heart failure.
  • Practice guideline summary: Use of fMRI in the presurgical evaluation of patients with epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. [Practice Guideline]
  • NeurNeurology 2017 Jan 24; 88(4):395-402
  • Szaflarski JP, Gloss D, … Theodore WH
  • CONCLUSIONS: The use of fMRI may be considered an option for lateralizing language functions in place of intracarotid amobarbital procedure (IAP) in patients with medial temporal lobe epilepsy (MTLE; Level C), temporal epilepsy in general (Level C), or extratemporal epilepsy (Level C). For patients with temporal neocortical epilepsy or temporal tumors, the evidence is insufficient (Level U). fMRI may be considered to predict postsurgical language deficits after anterior temporal lobe resection (Level C). The use of fMRI may be considered for lateralizing memory functions in place of IAP in patients with MTLE (Level C) but is of unclear utility in other epilepsy types (Level U). fMRI of verbal memory or language encoding should be considered for predicting verbal memory outcome (Level B). fMRI using nonverbal memory encoding may be considered for predicting visuospatial memory outcomes (Level C). Presurgical fMRI could be an adequate alternative to IAP memory testing for predicting verbal memory outcome (Level C). Clinicians should carefully advise patients of the risks and benefits of fMRI vs IAP during discussions concerning choice of specific modality in each case.
  • [Attempted suicide with barbiturates purchased online]. [Journal Article]
  • NTNed Tijdschr Geneeskd 2016; 160(0):D491
  • Chavoushi SF, Mesman L, … van Maarseveen EM
  • CONCLUSIONS: In patients with coma, respiratory depression, absence of brainstem reflexes and shock with no evident cause one should be aware of the possibility of barbiturate intoxication, even when there is no indication that these have been prescribed or that the patient has direct or indirect access to barbiturates. Prompt, optimal supportive therapy will give a good chance of full somatic recovery.
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