- Characterization of childhood exposure to environmental contaminants using stool in a semi-urban middle-class cohort from eastern Canada. [Journal Article]Environ Res. 2023 Jan 25 [Online ahead of print]ER
- Children are exposed to various environmental organic and inorganic contaminants with effects on health outcomes still largely unknown. Many matrices (e.g., blood, urine, nail, hair) have been used to characterize exposure to organic and inorganic contaminants. The sampling of feces presents several advantages; it is non-invasive and provides a direct evaluation of the gut microbiome exposure to …
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- Hypertensive disorders of pregnancy pre- and post-aspirin guideline publication in individuals with pre-gestational diabetes mellitus. [Journal Article]Am J Obstet Gynecol MFM. 2023 Jan 25 [Online ahead of print]AJ
- CONCLUSIONS: Delivery post-USPSTF aspirin guideline publication was associated with higher rates of hypertensive disorders of pregnancy and preterm birth in a population of individuals with diabetes mellitus. It is unknown whether patient or practitioner factors, or other changes in obstetric care, contributed to these findings.
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- Hsp90 protected chicken primary myocardial cells from heat-stress injury by inhibiting oxidative stress and calcium overload in mitochondria. [Journal Article]Biochem Pharmacol. 2023 Jan 25 [Online ahead of print]BP
- Severe heat stress can cause human and animal heart failure and sudden death, which is an important issue of public health worldwide. Our previous studies in animals showed that myocardial cells injury was critical in the above process, and Hsp90 induction has a definite anti-myocardial injury effect, especially through aspirin (ASA). But the mechanism has not been fully clarified. In this study,…
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- Opium may affect coronary artery disease by inducing inflammation but not through the expression of CD9, CD36, and CD68. [Journal Article]J Investig Med. 2023 Jan 10 [Online ahead of print]JI
- The molecular mechanisms of opium action with regard to coronary artery disease (CAD) have not yet been determined. The aim of this study was to evaluate the effect of opium on the expression of scavenger receptors including CD36, CD68, and CD9 tetraspanin in monocytes and the plasma levels of tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), malondialdehyde (MDA), and nitric oxide m…
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- Fatty acids negatively regulate platelet function through formation of noncanonical 15-lipoxygenase-derived eicosanoids. [Journal Article]Pharmacol Res Perspect. 2023 Feb; 11(1):e01056.PR
- The antiplatelet effect of polyunsaturated fatty acids is primarily attributed to its metabolism to bioactive metabolites by oxygenases, such as lipoxygenases (LOX). Platelets have demonstrated the ability to generate 15-LOX-derived metabolites (15-oxylipins); however, whether 15-LOX is in the platelet or is required for the formation of 15-oxylipins remains unclear. This study seeks to elucidate…
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- Rationale and design of a randomised double-blind 2×2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis (INSPIRES). [Journal Article]Stroke Vasc Neurol. 2023 Jan 27 [Online ahead of print]SV
- CONCLUSIONS: The INSPIRES trial will assess the efficacy and safety of intensive antiplatelet therapy and immediate intensive statin therapy begun within 72 hours of onset in decreasing the recurrent stroke at 90 days in patients with acute mild ischaemic stroke or high-risk TIA of intracranial or extracranial atherosclerosis origin.
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- Aspirin use during pregnancy may be a potential risk for postpartum hemorrhage and increased blood loss: A systematic review and meta-analysis. [Review]Am J Obstet Gynecol MFM. 2023 Jan 24 [Online ahead of print]AJ
- CONCLUSIONS: Aspirin use during pregnancy is a potential risk for postpartum hemorrhage and do slightly increase the amount of postpartum blood loss. Without denying the combined value of aspirin, our conclusions raise alarm for clinicians to postpartum hemorrhage in women using aspirin during pregnancy.
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- Recent patent applications for coffee and coffee byproducts as active ingredients in cosmetics. [Journal Article]Int J Cosmet Sci. 2023 Jan 26 [Online ahead of print]IJ
- Coffee is one of the most consumed beverages worldwide, and its production and consumption generate large amounts of byproducts annually. Coffee byproducts and coffee beans are rich in bioactive compounds of great commercial value, including potential applications as active ingredients in skin care products and cosmetic formulations. In addition, there has been growing interest in the use of natu…
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- Corrigendum: Both caffeine and Capsicum annuum fruit powder lower blood glucose levels and increase brown adipose tissue temperature in healthy adult males. [Published Erratum]Front Physiol. 2022; 13:1127730.FP
- [This corrects the article DOI: 10.3389/fphys.2022.870154.].
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- Efficacy and safety of concomitant use of proton pump inhibitors with aspirin-clopidogrel dual antiplatelet therapy in coronary heart disease: A systematic review and meta-analysis. [Systematic Review]
- Background: Proton pump inhibitors (PPIs) are usually prescribed to prevent gastrointestinal (GI) complications in patients receiving dual antiplatelet therapy (DAPT). This systematic review and meta-analysis aimed to explore the efficacy and safety of the concomitant use of PPIs with aspirin-clopidogrel DAPT in patients with Coronary heart disease (CHD). Method: The PubMed, Embase, Cochrane Libr…
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- Multi-centre, randomised, open-label, blinded endpoint assessed, trial of corticosteroids plus intravenous immunoglobulin (IVIG) and aspirin, versus IVIG and aspirin for prevention of coronary artery aneurysms (CAA) in Kawasaki disease (KD): the KD CAA prevention (KD-CAAP) trial protocol. [Journal Article]
- CONCLUSIONS: Several recent studies have indicated that coronary complications associated with KD across Europe are much higher than early trials of IVIG had initially suggested. KD-CAAP directly addresses this issue by exploring the therapeutic benefit of adjunctive corticosteroids in unselected KD cases. If we find that corticosteroids prevent CAA and are safe, this is a cheap and widely available intervention that could be implemented immediately for the benefit of children.
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- Caffeine derived graphene-wrapped Fe3C nanoparticles entrapped in hierarchically porous FeNC nanosheets for boosting oxygen reduction reaction. [Journal Article]J Colloid Interface Sci. 2023 Jan 17; 637:216-224.JC
- It is a vital requirement to explore high-efficiency and stable electrocatalysts for oxygen reduction reaction (ORR) to further relieve energy depletion. However, it is a critical challenge to develop low cost and high-quality carbon-based catalysts. Herein, a caffeine chelation-triggered pyrolysis approach was developed to construct graphene-wrapped Fe3C nanoparticles incorporated in hierarchica…
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- Factors and perceptions associated with energy drink consumption among undergraduate students attending a rural university: a descriptive study. [Journal Article]J Am Coll Health. 2023 Jan 26 [Online ahead of print]JA
- Objectives: This study examined the prevalence, patterns, and knowledge of Energy Drink (ED) consumption among undergraduate students. Participants: Participants included students (n = 373) attending a medium-sized rural university in Texas. Methods: Students were surveyed anonymously using convenience sampling and a cross-sectional design with 15 items structured questionnaire. Results: Nearly 9…
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- Associated factors with Premenstrual syndrome and Premenstrual dysphoric disorder among female medical students: A cross-sectional study. [Journal Article]
- CONCLUSIONS: The prominent risk factors for Premenstrual Syndrome and Premenstrual Dysphoric Disorder were negative Rhesus blood type, menarche age, caffeine consumption, and self-reported depression.
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- CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction. [Journal Article]JAMA Netw Open. 2023 Jan 03; 6(1):e2247868.JN
- CONCLUSIONS: In this study, the risks of albuminuria, hyperfiltration, and hypertension increased with heavy coffee intake only among those with the AC and CC genotypes of CYP1A2 at rs762551 associated with slow caffeine metabolism, suggesting that caffeine may play a role in the development of kidney disease in susceptible individuals.
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- Effective, safe and efficient porcine model of Forrest Ib bleeding gastric and colonic ulcers. [Journal Article]Indian J Gastroenterol. 2023 Jan 26 [Online ahead of print]IJ
- CONCLUSIONS: We have demonstrated the effectiveness and safety of a porcine GI bleeding model utilizing IV heparin anticoagulation and either hybrid ESD or EMR-C techniques to create oozing-type bleeding ulcers in the stomach and colon with customizable size.
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- Antithrombotic treatment after stroke due to intracerebral haemorrhage. [Review]
- CONCLUSIONS: We did not identify beneficial or hazardous effects of short-term prophylactic dose parenteral anticoagulation and long-term oral antiplatelet therapy after ICH on important outcomes. Although there was a significant reduction in MACE and all major occlusive vascular events after long-term treatment with therapeutic dose oral anticoagulation for atrial fibrillation after ICH, the pooled estimates were imprecise, the certainty of evidence was only moderate, and effects on other important outcomes were uncertain. Large RCTs with a low risk of bias are required to resolve the ongoing dilemmas about antithrombotic treatment after ICH.
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- Antithrombotic treatment for retinal vein occlusion: a systematic review and meta-analysis. [Journal Article]J Thromb Haemost. 2022 Dec 22 [Online ahead of print]JT
- CONCLUSIONS: Anticoagulant therapy was associated with higher visual acuity improvement and fewer recurrent RVO events than antiplatelet therapy, at the cost of an acceptable proportion of bleeding complications.
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- Energy drink consumption in young subjects: a growing problem. [Journal Article]Pan Afr Med J. 2022; 43:107.PA
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- Secondary prevention of antithrombotic therapy in patients with stable cardiovascular disease at high ischemic risk: A network meta-analysis of randomized controlled trials. [Systematic Review]Front Cardiovasc Med. 2022; 9:1040473.FC
- CONCLUSIONS: The present network meta-analysis suggests that clopidogrel or ticagrelor monotherapy may be recommended first in this cohort of SCVD at high ischemic risk. But clopidogrel plus aspirin or rivaroxaban plus aspirin can still be considered for use in patients with recurrent MACEs.
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- Efficacy and safety outcomes of long-term anti-thrombotic treatment of chronic coronary artery disease: A systematic review and network meta-analysis. [Systematic Review]Front Cardiovasc Med. 2022; 9:1016390.FC
- CONCLUSIONS: The rivaroxaban regimen appeared to be the preferred long-term anti-thrombotic regimen in preventing all-cause mortality. Our available results tend to support the efficacy of extended anti-thrombotic therapy consisting of prasugrel in lowering MI incidence compared to the other strategies, without increased risk of bleeding. However, additional large-scale direct clinical trials are needed to further determine the adequate long-term anti-thrombotic regimens for treating chronic coronary syndrome.
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- Ramadan diurnal intermittent fasting is associated with significant plasma metabolomics changes in subjects with overweight and obesity: A prospective cohort study. [Journal Article]Front Nutr. 2022; 9:1008730.FN
- During the holy month of Ramadan, adult healthy Muslims are mandated to abstain from dawn to sunset, with free eating at night hours that may extend up to 12 h. The current work was designed to investigate the metabolomics changes incurred upon the observance of Ramadan diurnal intermittent fasting (RDIF).
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- The striatum drives the ergogenic effects of caffeine. [Journal Article]Purinergic Signal. 2023 Jan 26 [Online ahead of print]PS
- Caffeine is one of the main ergogenic resources used in exercise and sports. Previously, we reported the ergogenic mechanism of caffeine through neuronal A2AR antagonism in the central nervous system [1]. We now demonstrate that the striatum rules the ergogenic effects of caffeine through neuroplasticity changes. Thirty-four Swiss (8-10 weeks, 47 ± 1.5 g) and twenty-four C57BL/6J (8-10 weeks, 23.…
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- Genotype-Guided Dual Antiplatelet Therapy in Minor Stroke or Transient Ischemic Attack With a Single Small Subcortical Infarction. [Journal Article]Neurology. 2023 Jan 25 [Online ahead of print]Neur
- CONCLUSIONS: In this prespecified substudy, ticagrelor-aspirin was superior to clopidogrel-aspirin in reducing the risk of stroke at 90 days among SSSI patients who carried CYP2C19 LOF allele(s). Although there was no treatment-by-heterogeneous etiology interaction, a greater absolute risk reduction of stroke was observed in patients with SSSI-ICAS than in those with SSSI+ICAS.
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- Thromboprophylaxis in the Fontan Circulation: Long-Awaited Validation. [Editorial]J Am Coll Cardiol. 2023 Jan 31; 81(4):390-393.JACC
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- Thromboprophylaxis in Patients With Fontan Circulation. [Journal Article]J Am Coll Cardiol. 2023 Jan 31; 81(4):374-389.JACC
- CONCLUSIONS: Aspirin, warfarin, and NOAC are associated with lower risk of thromboembolic events. Recognizing the limited number of patients and heterogeneity of studies using NOACs, the results support the safety and efficacy of NOACs in patients with a Fontan circulation.
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- Fixed dose combination drugs for cardiovascular disease in a prolonged humanitarian crisis in Lebanon: an implementation study. [Journal Article]BMJ Open. 2023 Jan 25; 13(1):e063668.BO
- CONCLUSIONS: Implementing an ASCVD secondary prevention FDC improved adherence and CVD risk factors in MSF clinics in Lebanon, with potential for wider implementation by humanitarian actors and host health systems.
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- Health-related quality of life and its determinants among patients with diabetes mellitus: a multicentre cross-sectional study in Northwest Ethiopia. [Multicenter Study]BMJ Open. 2023 Jan 25; 13(1):e068518.BO
- CONCLUSIONS: This study concluded that the HRQoL of patients was compromised in all five measuring dimensions. The EQ-5D-5L utility and EQ-VAS scores were far lower than other findings. Clinical and medication-related variables, such as a higher BMI, a higher number of medications, the presence of comorbidities and/or complications, hypoglycaemia and insulin use were associated with poor HRQoL in patients with diabetes. As a result, interventions should be individualised and focused on determinant factors.
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- Chemical sensory investigation in green and roasted beans Coffea arabica L. (cv. Yellow Bourbon) by various brewing methods using electronic sensors. [Journal Article]J Food Sci. 2023 Jan 25 [Online ahead of print]JF
- This study investigated the effects of four brewing methods (cold and hot brew, espresso, and cezve) on the chemical sensory properties of green and roasted coffee beans (cv. Yellow Bourbon) extract. The caffeine and chlorogenic acid contents of the coffee were analyzed using HPLC. The taste and volatile aromatic compounds of coffee were analyzed using an electronic tongue and nose, respectively,…
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- Intravenous immunoglobulin for the treatment of Kawasaki disease. [Review]
- CONCLUSIONS: The included RCTs investigated a variety of comparisons, and the small number of events observed during the study periods limited detection of effects. The certainty of the evidence ranged from moderate to very low due to concerns related to risk of bias, imprecision, and inconsistency. The available evidence indicated that high-dose IVIG regimens are probably associated with a reduced risk of CAA formation compared to ASA or medium- or low-dose IVIG regimens. There were no clinically significant differences in incidence of adverse effects, which suggests there is little concern about the safety of IVIG. Compared to ASA, high-dose IVIG probably reduced the duration of fever, but there was little or no difference detected in the need for additional treatment. Compared to medium- or low-dose IVIG, there may be reduced duration of fever and reduced need for additional treatment. We were unable to draw any conclusions regarding acute coronary syndromes, mortality, or length of hospital stay, or for the comparison IVIG versus prednisolone. Our findings are in keeping with current guideline recommendations and evidence from long-term epidemiology studies.
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