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4,153 results
  • The Pharmacological Treatment of Obsessive-Compulsive Disorder. [Review]
    Psychiatr Clin North Am. 2023 Mar; 46(1):107-119.Pittenger C
  • Pharmacological treatment is a mainstay of the care of individuals with obsessive-compulsive disorder. Robust evidence supports the use of the selective serotonin reuptake inhibitors and the older tricyclic drug clomipramine. Other antidepressants are less effective (or have been insufficiently studied). When first-line treatment with these agents, and with appropriate psychotherapy, is ineffecti…
  • Chitosan Aerogel Particles as Nasal Drug Delivery Systems. [Journal Article]
    Gels. 2022 Dec 04; 8(12)Menshutina N, Majouga A, … Silantyev A
  • The nasal drug delivery route has distinct advantages, such as high bioavailability, a rapid therapeutic effect, non-invasiveness, and ease of administration. This article presents the results of a study of the processes for obtaining chitosan aerogel particles that are promising as nasal or inhalation drug delivery systems. Obtaining chitosan aerogel particles includes the following steps: the p…
  • Screening Key Pathogenic Genes and Small Molecule Compounds for PNET. [Journal Article]
    J Pediatr Hematol Oncol. 2022 Dec 15 [Online ahead of print]Zhou Q, Liu H, … Xin C
  • Primitive neuroectodermal tumors (PNET) are rare malignant tumors, but the mortality rate of the patients is extremely high. The aim of this study was to identify the hub genes and pathways involved in the pathogenesis of PNET and to screen the potential small molecule drugs for PNET. We extracted gene expression profiles from the Gene Expression Omnibus database and identified differentially exp…
  • StatPearls: Tilt Table [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)ZyskoDorotaDWroclaw Medical University, PolandJamilRadia T.RTAllama Iqbal Medical CollegeAnilkumarArayamparambil C.ACSUNY Upstate Medical UniversityBOOK
  • Syncope may be caused by inadequate regulation of the heart and vessels function by the autonomic nervous and neuroendocrine systems. A tilt table test is a diagnostic procedure for patients with syncope of unknown origin. During the test, the patient is exposed to orthostatic stress, which may be exaggerated during the negative-passive phase of the test by nitroglycerine, clomipramine, and isopr…
  • Psychotropic medication in pregnancy and lactation and early development of exposed children. [Journal Article]
    Br J Clin Pharmacol. 2023 Feb; 89(2):737-750.Leutritz AL, van Braam L, … Kittel-Schneider S
  • There is still limited knowledge about alterations of blood concentrations of psychotropic drugs during pregnancy, the transfer of psychotropic drugs into breastmilk and the effects on exposed children. We investigated changes in concentrations of psychopharmacological medication during pregnancy and lactation in serum and breastmilk at different time points in a naturalistic sample of 60 mothers…
  • Majority of men with premature ejaculation do not receive pharmacotherapy. [Journal Article]
    Int J Impot Res. 2022 Jul 15 [Online ahead of print]Zucker I, Nackeeran S, … Ramasamy R
  • Premature ejaculation is the most common male sexual dysfunction, with therapies including selective serotonin reuptake inhibitors, clomipramine, topical anesthetics, dapoxetine and tramadol. However, it is currently unknown how many men are receiving pharmacotherapy for premature ejaculation. Using the TriNetX Research network, a large multicenter database containing over 75 million patient reco…
  • Lysosomal sequestration of weak base drugs, lysosomal biogenesis, and cell cycle alteration. [Journal Article]
    Biomed Pharmacother. 2022 Sep; 153:113328.Mlejnek P, Havlasek J, … Dostalova K
  • Lysosomes, now known to take part in multiple cellular functions, also respond to various stress stimuli. These include biogenesis in response to nanomolar concentrations of hydrophobic weak-base anticancer drugs. However, since lysosomal stress mediated by accumulation of weak-base drugs at such concentrations has never been proven and these drugs have diverse effects on malignant cells, we inve…
  • StatPearls: Clomipramine [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)WilsonMarciaMTrippJaysonJCUSOM/Cape Fear Valley Health CenterBOOK
  • The only FDA approved use for clomipramine is for treating obsessive-compulsive disorder (OCD) in ages 10 and older. For the treatment of OCD, clomipramine was found to be more effective than sertraline, fluoxetine, and fluvoxamine in a meta-analysis. Clomipramine is used off-label to treat patients with depression, anxiety, treatment-resistant depression, cataplexy syndrome, insomnia, neuropathi…
  • Anti-depressants and COVID-19: A New Ray of Hope. [Journal Article]
    Psychiatr Danub. 2022 Spring; 34(1):171-173.Khan E, Jani I, … Hasan MM
  • The coronavirus disease pandemic has grown worldwide. As we understand the exact pathophysiology of the disease and how it affects the systems in the human body, we are in the process of discovering and repositioning drugs potentially effective in these regards. A few targets of these drugs are excessive inflammation following SARS-CoV-2 infection and sigma-1 receptor ER chaperone protein, which …
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