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3,941 results
  • Recent Advances and Challenges of the Drugs Acting on Monoamine Transporters. [Journal Article]
  • CMCurr Med Chem 2018 Oct 09
  • Xue W, Fu T, … Zhu F
  • CONCLUSIONS: The reported new compounds act on hMATs as well as the structures of the transporters complexed with diverse ligands by either experiment or computational modeling have shed light on the poly-pharmacology, multimodal and allosteric regulation of the drugs to transporters. All of the studies will greatly promote the structure-based drug design (SBDD) of structurally novel scaffolds with high activity and selectivity for hMATs.
  • Antidepressants in epilepsy. [Review]
  • NNNeurol Neurochir Pol 2018 Aug 11
  • Górska N, Słupski J, … Gałuszko-Węgielnik M
  • People with epilepsy (PWE) frequently suffer from comorbid mood and anxiety disorders. Depression is one of the major psychiatric comorbidities having a negative impact on the quality of life in peop...
  • Psychopharmacological treatment of Obsessive-Compulsive Disorder (OCD). [Journal Article]
  • CNCurr Neuropharmacol 2018 08 13
  • Del Casale A, Sorice S, … Pompili M
  • CONCLUSIONS: SSRI/clomipramine in combination with CBT/ERP is associated with the optimal response compared to each treatment alone or to other treatments. New strategies for refractory OCD are needed. The role of pharmacogenomics could become preponderant in the coming years.
  • Drug treatment options for premature ejaculation. [Review]
  • EOExpert Opin Pharmacother 2018; 19(10):1077-1085
  • Waldinger MD
  • Various drugs are available for lifelong and acquired premature ejaculation (PE), but only dapoxetine and FortacinTM have been officially registered. On the other hand, all sorts of pharmacologically...
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