- Case Report of Anal Fissures and Hemorrhoids Treated with Compounded Cromolyn Sodium and Naltrexone Hydrochloride in MEDISCA's SPG SUPPOSI-BASE. [Case Reports]Int J Pharm Compd. 2023 Jan-Feb; 27(1):6-10.IJ
- The purpose of this case report is to evaluate and demonstrate the benefits of compounded therapy in treating chronic rectal fissures with hemorrhoids using a compounded suppository containing cromolyn sodium and naltrexone hydrochloride in MEDISCA's SPG SUPPOSI-BASE. The primary outcomes of symptomatic improvement and healed fissure were reported and confirmed by the practitioner and, via self-a…
- Efficacy of Anal Sphincter Division During Fistulotomy in Anal Fissure Associated Fistula. [Journal Article]Dis Colon Rectum. 2023 Jan 24 [Online ahead of print]DC
- CONCLUSIONS: Patients presenting with chronic fissure and associated subcutaneous, intersphincteric, or low transphincteric fistula are successfully managed with fistulotomy. Patients with a subcutaneous fistula tract exhibited non-statistically significant lower rates of healing. See Video Abstract at http://links.lww.com/DCR/C145.
- Publisher Full Text (DOI)
- Analfissur: Bei politisch Verfolgten an Folter denken. [Journal Article]MMW Fortschr Med. 2023 01; 165(1):34.MF
- Publisher Full Text (DOI)
- Clinical outcomes of Medical management options for chronic anal fissures in a long term follow up: systematic review and meta-analysis. [Systematic Review]Dig Dis. 2023 Jan 16 [Online ahead of print]DD
- CONCLUSIONS: Calcium channel blockers performed well regarding the healing of CAF when compared to others in long-term follow-up. The superiority of botulinum toxin was not evidenced compared to topical treatments. More studies are needed to better assess recurrence rates.
- Publisher Full Text (DOI)
- Pelvic floor physical therapy in patients with chronic anal fissure: long-term follow-up of a randomized controlled trial. [Randomized Controlled Trial]
- CONCLUSIONS: In the PAF-trial, we demonstrated that pelvic floor physical therapy yields a significant and clinical benefit in the time course and therefore should be advocated as adjuvant conservative treatment in patients with chronic anal fissure.
- PMC Free PDF
- Pelvic floor physical therapy in the treatment of chronic anal fissure (PAF trial): quality of life outcome. [Randomized Controlled Trial]
- CONCLUSIONS: The results of this study provide evidence that treatment by pelvic floor physical therapy improves quality of life and reduces pain, making it an important tool in management of chronic anal fissure and concomitant pelvic floor dysfunction.
- PMC Free PDF
- Causes and Management of Pruritus Ani. [Case Reports]
- A 48-year-old healthy man presented to the office reporting a long-standing history of anal pruritus. He had tried various over-the-counter creams without much success. Besides an anal fissure in the past, which responded to nitroglycerin ointment, his medical history was unremarkable. On physical examination, he was found to have grade I hemorrhoids and mild fecal smearing on perianal skin. Rece…
- Publisher Full Text (DOI)
- L-Arginine is a feasible supplement to heal chronic anal fissure via reducing internal anal sphincter pressure: a randomized clinical trial study. [Journal Article]
- The hypertonicity of internal anal sphincter resting pressure is one of the main causes of chronic anal fissure. Therefore, the aim of this study was to assess the effect of oral administration of L-arginine on the improvement of the anal fissures by relaxing the internal anal sphincter. Seventy-six chronic anal fissure patients (aged 18-65 years) who were referred to Rasoul-e-Akram Hospital, Teh…
- PMC Free PDF
- Local plus oral antibiotics and strict avoidance of constipation is effective and helps prevents surgery in most cases of anal fissure. [Journal Article]Ann Coloproctol. 2022 Nov 29 [Online ahead of print]AC
- Publisher Full Text (DOI)
- Severe anogenital ulceration in a preterm neonate. [Journal Article]Pediatr Dermatol. 2022 11; 39(6):976-978.PD
- Publisher Full Text (DOI)
- Comparative Efficacy of Topical Metronidazole and Glyceryl Trinitrate Versus Topical Glyceryl Trinitrate Alone in the Treatment of Acute Anal Fissure: A Randomized Clinical Trial. [Journal Article]
- Background and objective An anal fissure is a longitudinal, oval lesion in the anal canal. In over 90% of instances, the anal fissures are located posterior to the midline and produce discomfort upon defecation and/or bleeding owing to spasms of the internal anal sphincter that leads to ischemia. This research aimed to determine if topical metronidazole treatment when combined with glyceryl trini…
- PMC Free PDF
- Lateral Internal Anal Sphincterotomy of Chronic Anal Fissure: An Experience of 165 Cases. [Journal Article]
- The anal fissure is frequently seen in surgical practice. It is caused by a longitudinal tear in the anoderm distal to the dentate line. The hallmark feature of the disease is severe pain during defecation. Chronic anal fissure (CAF) causes undue stress that leads to poor quality of life. Different options of treatment, whether medical or surgical, are employed to treat this condition. One of the…
- PMC Free PDF
- TikTok and YouTube as sources of information on anal fissure: A comparative analysis. [Journal Article]
- CONCLUSIONS: The sources of uploaders on YouTube are more diverse than TikTok, and the quality of videos is also relatively higher on YouTube. Even so, the video quality of the two platforms still needs to be further improved. Health information without integrity, reliability and practicability impacts patients' disease perception and health-seeking behavior, leading to serious consequences. Much effort must be taken to improve the quality of videos regarding anal fissures on the two platforms, which will facilitate the development of public health education on this issue.
- PMC Free PDF
- The role of the Rafaelo procedure in the management of hemorrhoidal disease: a systematic review and meta-analysis. [Review]
- CONCLUSIONS: Further randomized controlled trials are required to delineate the exact role of the Rafaelo procedure in HD.
- Publisher Full Text (DOI)
- StatPearls: Anal Fissures [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- An anal fissure is a superficial tear in the skin distal to the dentate line and is a cause of frequent emergency department visits. In most cases, anal fissures are a result of hard stools or constipation, or injury. Anal fissures are common in both adults and children, and those with a history of constipation tend to have more frequent episodes of this condition. Anal fissures can be acute (las…
- A Rare Congenital Perineal Groove. [Case Reports]
- CONCLUSIONS: Recognition of the congenital perineal groove at birth is important for the health care providers to deliver an appropriate parental counseling and appropriate follow-up.
- PMC Free PDF
- The Efficacy of Sitz Baths as Compared to Lateral Internal Sphincterotomy in Patients with Anal Fissures: A Systematic Review. [Review]
- An anal fissure is a common condition that affects patients of all ages. Its clinical presentation is a sharp pain on defecation with or without blood. It is treated by conservative or surgical means. This study aims to assess the efficacy of a sitz bath as compared to lateral internal sphincterotomy in the treatment of anal fissures. The search strategy used keywords related to the topic of stud…
- PMC Free PDF
- Use of telemedicine in the postoperative assessment of proctological patients: a case-control study. [Journal Article]
- CONCLUSIONS: The use of WhatsApp in the post-discharge period improves the lifestyle quality of the patients and their perception of the safety and quality of care received.
- PMC Free PDF
- The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Anal Fissures. [Journal Article]Dis Colon Rectum. 2023 Feb 01; 66(2):190-199.DC
- Publisher Full Text (DOI)
- Endoscopic Ultrasound-Guided Botox Injection for Refractory Anal Fissure. [Journal Article]
- CONCLUSIONS: EUS-guided botox injection into the internal sphincter appears to be a promising technique for patients with refractory anal fissure with pain.
- PMC Free PDF
- Perineal stress as a predictor of performing episiotomy in primiparous women: a prospective observational study. [Journal Article]
- CONCLUSIONS: The level of perineal stress was an independent predictor of performing episiotomy in nulliparous women during non-instrumental vaginal delivery. Perineal stress exceeding 124.49 N was identified as the cut-off prompting midwives to perform episiotomy.
- PMC Free PDF
- Causes of bloody stools in neonates: a case series report. [Journal Article]
- CONCLUSIONS: Bloody stools in neonates is generally a benign, self-limiting disorder, not related to surgical conditions. The overall operation rate among neonates with bloody stools was only 1.7%. CMPA and NEC were the most common underlying non-surgical and surgical diseases, respectively, for neonates with bloody stools. Feeding choice is related to bloody stools in neonates, policies and strategies to support breastfeeding should be strengthened in the future.
- PMC Free PDF
- Comparison of botulinum toxin (BoNT) injection and lateral internal sphincterotomy (redo-LIS) for recurrent anal fissure treatment. [Journal Article]
- CONCLUSIONS: This study demonstrates that redo lateral internal sphincterotomy (LIS) is a reliable method for patients who received LIS but developed recurrent chronic anal fissure, and achieves successful results in terms of recurrence and relief of pain.
- PMC Free PDF
- Implantation metastasis from sigmoid colon cancer to rectal anastomosis proved by whole exome sequencing and lineage inference for cancer heterogeneity and evolution analysis: Case report and literature review. [Case Reports]
- It was estimated that 70% of patients with colorectal cancer were found to have viable exfoliated malignant cells in adjacent intestinal lumen. Exfoliated malignant cells had been reported to implant on raw surfaces, such as polypectomy site, anal fissure, anal fistula, hemorrhoidectomy wound, and anastomotic suture line. Tumors at anastomosis could be classified into four groups: local recurrenc…
- PMC Free PDF
- Solitary Rectal Ulcer Syndrome: A Rare and Often Misdiagnosed Cause of Rectal Bleeding in Children. [Journal Article]Mymensingh Med J. 2022 Oct; 31(4):1206-1211.MM
- Solitary rectal ulcer syndrome (SRUS) is an uncommon benign rectal disorder. Typically, young adults are affected and it is rare in children. Straining during defecation, self-induced trauma and paradoxical contraction of puborectalis muscle are the major contributing factors of this condition. Clinical features of SRUS are rectal bleeding, mucorrhoea, excessive straining during defecation, tenes…
- Clinical Outcome of 0.2% Glyceryl Trinitrate Topical Ointment Compared to Lateral Internal Sphincterotomy in the Treatment of Patient with Chronic Anal Fissure: A Randomized Control Trial. [Randomized Controlled Trial]Mymensingh Med J. 2022 Oct; 31(4):1034-1039.MM
- The objective of study was to evaluate the clinical outcome of topical 0.2% Glyceryl trinitrate topical (GTN) ointment in the treatment of chronic anal fissure. This randomized control trial was carried out in the Colorectal Surgery Unit, Department of Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh from May 2015 to April 2016. Total 94 patients were included in this tria…
- Treatment of Haemorrhoidal Disease by Laser Haemorrhoidoplasty at Dakar Preliminary Study of 21 Patients. [Journal Article]
- CONCLUSIONS: Laser haemorrhoidoplasty is a minimally invasive alternative for the treatment of haemorrhoidal disease, especially for grade 2 and 3 haemorrhoids without major prolapse. Postoperative pain is minimal, and the risk of stenosis or incontinence is almost non-existent.
- PMC Free PDF
- StatPearls: Internal Anal Sphincterotomy [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- An anal fissure is a common benign anorectal disease affecting both children and adults. It is defined as a painful linear tear in the posterior anoderm extending cephalad to the dentate line. Classically these are caused by a large, firm, forceful bowel movement. This results in cycles of recurring anal pain and bleeding leading to chronic anal fissures in as many as 40% of patients who develops…