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Unbound Medicine.
(Analgesic drugs)
639,049 results
  • Transethosomes: A Promising Challenge for Topical Delivery Short Title: Transethosomes for Topical Delivery. [Journal Article]
    Drug Res (Stuttg). 2023 Feb 03 [Online ahead of print]Adnan M, Haider MF, … Haider T
  • Skin provides an excellent barrier to molecular transport, as the stratum corneum is the most formidable barrier to the passage of most pharmaceuticals. Various attempts have been made to improve drug administration into the body through intact skin. Though very few routes are as attractive as the topical route, drug transport through the skin is challenging. To overcome the challenges, researche…
  • Cancer-induced pain management by nanotechnology-based approach. [Journal Article]
    Curr Pharm Biotechnol. 2023 Jan 23 [Online ahead of print]Dash SR, Kundu CN
  • Cancer patients frequently report experiencing pain as one of their symptoms. Cancerrelated pain is often caused by the tumor itself, especially when the tumor is pressing on nerves. In addition to the pain caused by the tumor itself, patients also experience discomfort from the treatment, such as surgery, chemotherapy, radiation therapy, and the diagnostic procedures. The majority of today's pai…
  • Synthesis of Gingerol-Metals Complex and in-vitro Cytotoxic Activity on Human Colon Cancer Cell Line. [Journal Article]
    Cancer Manag Res. 2023; 15:87-98.Khdary NH, Alangari AA, … Alanazi IO
  • Herbs are excellent sources of medicinal substances, and their curative abilities have been recognized to treat many ailments and are used for example as antioxidants, analgesics, anti-inflammatories, antipyretics, and many other medicinal uses. The properties of natural compounds and their health effects have been studied extensively, especially those that originate from plant sources such as gi…
  • Modulation of GABAA receptors and of GABAergic synapses by the natural alkaloid gelsemine. [Journal Article]
    Front Mol Neurosci. 2022; 15:1083189.Marileo AM, Gavilán J, … Yévenes GE
  • The Gelsemium elegans plant preparations have shown beneficial activity against common diseases, including chronic pain and anxiety. Nevertheless, their clinical uses are limited by their toxicity. Gelsemine, one of the most abundant alkaloids in the Gelsemium plants, have replicated these therapeutic and toxic actions in experimental behavioral models. However, the molecular targets underlying t…
  • Public perception of household risks for pediatric burn injuries and assessment of management readiness. [Journal Article]
    Burns. 2023 Jan 27 [Online ahead of print]Lagziel T, Lopez CD, … Redett RJ
  • CONCLUSIONS: This study revealed a significant gap in public awareness of household risks for pediatric burns. Furthermore, while most individuals would not seek medical care for a first-degree pediatric burn injury, they were readily available to identify proper initial management methods. This gap in knowledge and understanding of household pediatric burn injuries should be addressed with increased burn injury prevention education initiatives and more parental counseling opportunities.
  • [What is the real price of SOP and OTC drugs? Pilot study on paracetamol]. [Journal Article]
    Epidemiol Prev. 2023 Jan-Apr; 47(1-2):In press.Milozzi F, Di Filippo A, … Trotta F
  • CONCLUSIONS: wide and homogeneous distribution of unbranded products from different holders is available throughout the country. These products have significantly lower prices than branded packages, and they also have heavy discounts applied (up to 70%, with minimum price per tablet going as low as 0.05 euros). However, contrary to what these premises might lead one to think, consumption is concentrated on the branded packages having the highest prices. For proper information to citizens and trade associations, it is important for the media to bring awareness of the real savings opportunities available nationwide for products of frequent and widespread use, such as the case of paracetamol 500 mg.
  • Neuropathic pain: Mechanisms and therapeutic strategies. [Review]
    Front Cell Dev Biol. 2023; 11:1072629.Petroianu GA, Aloum L, Adem A
  • The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The number of pharmacodynamically distinct and clinically available medications is low and the successes achieved modest. Pain Medicine practitioners are confronted with the ethical dichotomy imposed by Hippocrates: On …
  • NHANES cross sectional study of aspirin and fractures in the elderly. [Journal Article]
    Sci Rep. 2023 Feb 01; 13(1):1879.Swed S, El-Sakka AA, … Rakab A
  • Bone fractures are a global public health concern, yet no thorough investigation of low-dose aspirin usage to prevent fractures in the elderly has been conducted. Many interventional human and animal studies have tried to detect the correct role of low-dose aspirin on fractures in elderly persons. The literature doesn't consist of a retrospective observational study that includes a large number o…
  • [Effects of Huangqin Tang on NLRP3/Caspase-1 pathway in mice model of ulcerative colitis]. [Journal Article]
    Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(1):226-233.Liu MR, Li H, … Tian YZ
  • The aim of this study was to explore the effects of Huangqin Tang(HQT) on the NLRP3/Caspase-1 signaling pathway in mice with DSS-induced ulcerative colitis(UC). C57BL/6J mice were randomly divided into a blank group, a model group(DSS group), and low-, medium-and high-dose HQT groups(HQT-L, HQT-M, and HQT-H), and western medicine mesalazine group(western medicine group). The UC model was induced …
  • [Effect of Rhizophagus intraradices on growth of Salvia miltiorrhiza]. [Journal Article]
    Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(2):349-355.Zheng LL, Chen ML, … Zhou XT
  • The study aimed to explore the effects of inoculation of Rhizophagus intraradices on the biomass, effective component content, and endogenous hormone content of Salvia miltiorrhiza through pot experiments. The number of leaves, plant height, dry weight of aboveground and underground parts, branch number, root number, root length, root diameter, and other biomass were mea-sured by weighing and cou…
  • [Traditional Chinese medicine therapy for rheumatoid arthritis: a review]. [Review]
    Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(2):329-335.Chang C, Zhang RR, … He DY
  • Rheumatoid arthritis(RA) is an autoimmune disease that seriously affects the physical and mental health of patients, but its pathogenesis is still unclear. At present, clinical treatment drugs include conventional synthetic disease modifing anti-rheumatic drugs(csDMARDs), nonsteroid anti-inflammtory drugs(NSAIDs), hormones, small molecule targeted drugs, biological agents, etc. These drugs can re…
  • Activation of the Keap1/Nrf2 Pathway as an Adaptive Response to an Electrophilic Metabolite of Morphine. [Journal Article]
    Biol Pharm Bull. 2023; 46(2):338-342.Matsuo K, Abiko Y, … Kumagai Y
  • Morphinone (MO) is an electrophilic metabolite of morphine that covalently binds to protein thiols via its α,β-unsaturated carbonyl group, resulting in toxicity in vitro and in vivo. Our previous studies identified a variety of redox signaling pathways that are activated during electrophilic stress. Here, we examined in vitro activation of a signaling pathway involving Kelch-like ECH-associated p…
  • Activation of HSP90/HSF1 Signaling as an Adaptive Response to an Electrophilic Metabolite of Morphine. [Journal Article]
    Biol Pharm Bull. 2023; 46(2):334-337.Matsuo K, Abiko Y, … Kumagai Y
  • Morphinone (MO) is an electrophilic metabolite of morphine that covalently binds to protein thiols, resulting in toxicity in vitro and in vivo. We have previously identified a variety of redox signaling pathways that are activated during electrophilic stress. However, the role of MO in such activation remains unknown. In this study, we examined whether MO could activate heat shock protein (HSP) 9…
  • [Survey of Prophylactic Administration of Naldemedine for Opioid-induced Constipation]. [Journal Article]
    Yakugaku Zasshi. 2023; 143(2):183-189.Ozawa Y, Haruki Y, … Hayashi S
  • Opioid-induced constipation (OIC), an adverse event that occurs due to opioid analgesics, reportedly causes poor quality of life and adherence to opioid analgesics in patients. Therefore, this issue must be addressed appropriately. Naldemedine (NAL), a peripherally-acting μ-opioid receptor antagonist, is currently recommended for treating OIC when other laxatives are ineffective, but there have b…
  • Prior authorization restrictions on medications for opioid use disorder: trends in state laws from 2005 to 2019. [Journal Article]
    Ann Med. 2023 Dec; 55(1):514-520.Andraka-Christou B, Golan O, … Stein BD
  • CONCLUSIONS: The number of states with an MOUD prior authorization law prohibition increased in recent years. Such laws could help expand access to life-saving OUD treatments by making it easier for clinicians to prescribe MOUD.KEY MESSAGESNo states had MOUD prior authorization prohibitions between 2005 and 2015 in state statutes or regulations, and only one state had such a prohibition in 2016.By 2019, fifteen states had an MOUD prior authorization prohibition law.States varied significantly in their approach to prohibiting MOUD prior authorization, including with respect to the insurer type, duration of the prohibition, and applicable medication.
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