- Embolization of the Superior Rectal Arteries versus Closed Hemorrhoidectomy (Ferguson Technique) in the treatment of Hemorrhoidal Disease: A Randomized Clinical Trial. [Journal Article]J Vasc Interv Radiol. 2023 Jan 31 [Online ahead of print]JV
- CONCLUSIONS: Despite no difference achieved in outcomes, embolization of the superior rectal arteries for the treatment of hemorrhoidal disease showed pain levels lower than those observed in surgical treatment.
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- Transethosomes: A Promising Challenge for Topical Delivery Short Title: Transethosomes for Topical Delivery. [Journal Article]Drug Res (Stuttg). 2023 Feb 03 [Online ahead of print]DR
- Skin provides an excellent barrier to molecular transport, as the stratum corneum is the most formidable barrier to the passage of most pharmaceuticals. Various attempts have been made to improve drug administration into the body through intact skin. Though very few routes are as attractive as the topical route, drug transport through the skin is challenging. To overcome the challenges, researche…
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- Perioperative Pain Management With Opioid Analgesics in Colpopexy Increases Risk of New Persistent Opioid Usage. [Journal Article]Urogynecology (Hagerstown). 2023 Feb 01; 29(2):183-190.U
- CONCLUSIONS: We identified that opioid dependence may occur after surgery if patients are given opioids within 7 days of either approach, associating opioid dependence with perioperative opioid usage rather than the approach taken.
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- Cancer-induced pain management by nanotechnology-based approach. [Journal Article]Curr Pharm Biotechnol. 2023 Jan 23 [Online ahead of print]CP
- Cancer patients frequently report experiencing pain as one of their symptoms. Cancerrelated pain is often caused by the tumor itself, especially when the tumor is pressing on nerves. In addition to the pain caused by the tumor itself, patients also experience discomfort from the treatment, such as surgery, chemotherapy, radiation therapy, and the diagnostic procedures. The majority of today's pai…
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- Fixed drug eruption: the often forgotten cutaneous adverse drug reaction. [Journal Article]Med J Aust. 2023 Feb 02 [Online ahead of print]MJ
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- Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern. (Asteraceae). [Journal Article]J Exp Pharmacol. 2023; 15:29-40.JE
- CONCLUSIONS: This study's findings indicate that the solvent fractions and 80% methanol extract of V. auriculifera have analgesic and anti-inflammatory properties. This study's findings not only confirm the plants' traditional claim but also provide clues for further investigation of the active principles of this plant for the development of effective and safe analgesic and anti-inflammatory drugs.
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- Synthesis of Gingerol-Metals Complex and in-vitro Cytotoxic Activity on Human Colon Cancer Cell Line. [Journal Article]Cancer Manag Res. 2023; 15:87-98.CM
- Herbs are excellent sources of medicinal substances, and their curative abilities have been recognized to treat many ailments and are used for example as antioxidants, analgesics, anti-inflammatories, antipyretics, and many other medicinal uses. The properties of natural compounds and their health effects have been studied extensively, especially those that originate from plant sources such as gi…
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- Modulation of GABAA receptors and of GABAergic synapses by the natural alkaloid gelsemine. [Journal Article]Front Mol Neurosci. 2022; 15:1083189.FM
- The Gelsemium elegans plant preparations have shown beneficial activity against common diseases, including chronic pain and anxiety. Nevertheless, their clinical uses are limited by their toxicity. Gelsemine, one of the most abundant alkaloids in the Gelsemium plants, have replicated these therapeutic and toxic actions in experimental behavioral models. However, the molecular targets underlying t…
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- The efficacy of oral pain relief cocktail during pan-retinal photocoagulation for diabetic retinopathy: a randomized clinical trial. [Journal Article]Int J Retina Vitreous. 2023 Feb 02; 9(1):10.IJ
- CONCLUSIONS: No evidence of the pain-relieving effect of N, P or NP was found during PRP.
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- Public perception of household risks for pediatric burn injuries and assessment of management readiness. [Journal Article]Burns. 2023 Jan 27 [Online ahead of print]B
- CONCLUSIONS: This study revealed a significant gap in public awareness of household risks for pediatric burns. Furthermore, while most individuals would not seek medical care for a first-degree pediatric burn injury, they were readily available to identify proper initial management methods. This gap in knowledge and understanding of household pediatric burn injuries should be addressed with increased burn injury prevention education initiatives and more parental counseling opportunities.
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- Sustained adherence to a delirium guideline five years after implementation in an intensive care setting: A retrospective cohort study. [Journal Article]Intensive Crit Care Nurs. 2023 Jan 31; 76:103398.IC
- CONCLUSIONS: Five years after ceasing of implementation efforts regarding the delirium guideline, partial sustainability has been achieved. The decrease in adherence to 'number of light sedation days' could have contributed to the increased length-of-stay on the intensive care unit.
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- Could C3, 4, and 5 Nerve Root Block be a Better Alternative to Interscalene Block Plus Intermediate Cervical Plexus Block for Patients Undergoing Surgery for Midshaft and Medial Clavicle Fractures? A Randomized Controlled Trial. [Journal Article]Clin Orthop Relat Res. 2022 Nov 18 [Online ahead of print]CO
- CONCLUSIONS: Based on our analysis of the data, a C3, 4, and 5 nerve root block was better than ISB combined with ICPB for surgery to treat medial shaft and medial clavicle fractures. When choosing the anesthesia method, however, the patient's basic physiologic condition and possible complications should be considered.
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- Artificial intelligence algorithms predict the efficacy of analgesic cocktails prescribed after orthopedic surgery. [Journal Article]PLoS One. 2023; 18(2):e0280995.Plos
- CONCLUSIONS: We observed that administering one analgesic or at most two is not effective. We found no statistical indicators that interactions between analgesics in the most effective cocktails decreased their effectiveness. Pairs of most effective cocktails differed by the addition of only one analgesic (Diclofenac-Orphenadrine for one pair and Hydromorphone for the other). We conclude that the listed cocktails are to be recommended.
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- [What is the real price of SOP and OTC drugs? Pilot study on paracetamol]. [Journal Article]Epidemiol Prev. 2023 Jan-Apr; 47(1-2):In press.EP
- CONCLUSIONS: wide and homogeneous distribution of unbranded products from different holders is available throughout the country. These products have significantly lower prices than branded packages, and they also have heavy discounts applied (up to 70%, with minimum price per tablet going as low as 0.05 euros). However, contrary to what these premises might lead one to think, consumption is concentrated on the branded packages having the highest prices. For proper information to citizens and trade associations, it is important for the media to bring awareness of the real savings opportunities available nationwide for products of frequent and widespread use, such as the case of paracetamol 500 mg.
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- Neuropathic pain: Mechanisms and therapeutic strategies. [Review]
- The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The number of pharmacodynamically distinct and clinically available medications is low and the successes achieved modest. Pain Medicine practitioners are confronted with the ethical dichotomy imposed by Hippocrates: On …
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- Anti-inflammatory, Antinociceptive, and Toxicological Properties of Uvaria comperei Stem Crude Extract and Fractions. [Journal Article]
- The present study was carried out to investigate the anti-inflammatory activity of a methanolic extract and fractions of Uvaria comperei stems. The crude extract was obtained by maceration of the powder in methanol and fractions by vacuum chromatography from the methanolic extract. To study the anti-inflammatory activity in vitro, red blood cell lysis inhibition assay and albumin denaturation inh…
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- Study protocol for a factorial-randomized controlled trial evaluating the implementation, costs, effectiveness, and sustainment of digital therapeutics for substance use disorder in primary care (DIGITS Trial). [Journal Article]
- CONCLUSIONS: The DIGITS Trial uses an experimental design to test whether implementation strategies increase and improve the delivery of digital therapeutics for SUDs when embedded in a large healthcare system. It will provide data on the potential benefits and cost-effectiveness of alternative implementation strategies.
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- NHANES cross sectional study of aspirin and fractures in the elderly. [Journal Article]
- Bone fractures are a global public health concern, yet no thorough investigation of low-dose aspirin usage to prevent fractures in the elderly has been conducted. Many interventional human and animal studies have tried to detect the correct role of low-dose aspirin on fractures in elderly persons. The literature doesn't consist of a retrospective observational study that includes a large number o…
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- [Effects of Huangqin Tang on NLRP3/Caspase-1 pathway in mice model of ulcerative colitis]. [Journal Article]Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(1):226-233.ZZ
- The aim of this study was to explore the effects of Huangqin Tang(HQT) on the NLRP3/Caspase-1 signaling pathway in mice with DSS-induced ulcerative colitis(UC). C57BL/6J mice were randomly divided into a blank group, a model group(DSS group), and low-, medium-and high-dose HQT groups(HQT-L, HQT-M, and HQT-H), and western medicine mesalazine group(western medicine group). The UC model was induced …
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- [Methyl ferulic acid ameliorates ethanol-induced L02 cell steatosis through microRNA-378b-mediated CaMKK2-AMPK pathway]. [Journal Article]Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(1):193-201.ZZ
- Alcoholic liver disease(ALD), with its increasing morbidity and mortality, has seriously and extensively affected the health of people worldwide. Methyl ferulic acid(MFA) has been proven to significantly inhibit alcohol-induced lipid production in L02 cells through the AMP-activated protein kinase(AMPK) pathway, but its in-depth mechanism remains unclear. This study aimed to further clarify the m…
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- [Application of microneedle-assisted percutaneous drug delivery system in treatment of rheumatoid arthritis:a review]. [Review]Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(1):13-21.ZZ
- Rheumatoid arthritis(RA) is a chronic degenerative joint disease characterized by inflammation. Due to the complex causes, no specific therapy is available. Non-steroidal anti-inflammatory agents and corticosteroids are often used(long-term, oral/injection) to interfere with related pathways for reducing inflammatory response and delaying the progression of RA, which, however, induce many side ef…
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- [Effect of Rhizophagus intraradices on growth of Salvia miltiorrhiza]. [Journal Article]Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(2):349-355.ZZ
- The study aimed to explore the effects of inoculation of Rhizophagus intraradices on the biomass, effective component content, and endogenous hormone content of Salvia miltiorrhiza through pot experiments. The number of leaves, plant height, dry weight of aboveground and underground parts, branch number, root number, root length, root diameter, and other biomass were mea-sured by weighing and cou…
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- [Traditional Chinese medicine therapy for rheumatoid arthritis: a review]. [Review]Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(2):329-335.ZZ
- Rheumatoid arthritis(RA) is an autoimmune disease that seriously affects the physical and mental health of patients, but its pathogenesis is still unclear. At present, clinical treatment drugs include conventional synthetic disease modifing anti-rheumatic drugs(csDMARDs), nonsteroid anti-inflammtory drugs(NSAIDs), hormones, small molecule targeted drugs, biological agents, etc. These drugs can re…
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- Efficacy of Kampo medicine Kakkonto as acute medication to treat tension-type headache among musculoskeletal pain patients using regular analgesics. [Journal Article]Rinsho Shinkeigaku. 2023 Jan 31 [Online ahead of print]RS
- CONCLUSIONS: Kakkonto showed efficacy as an acute medication for TTH with comorbidities that have been treated by analgesic.
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- Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine. [Journal Article]Chem Pharm Bull (Tokyo). 2023; 71(2):148-153.CP
- This study aimed to evaluate the bitterness of famotidine (FAM) combined with each of three non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), flurbiprofen (FLU), and naproxen (NAP), which have potential as fixed-dose combination (FDC) drugs. We evaluated the bitterness of FAM and each NSAID by taste sensor AN0 and C00, respectively. FAM showed high sensor output representing sensit…
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- Activation of the Keap1/Nrf2 Pathway as an Adaptive Response to an Electrophilic Metabolite of Morphine. [Journal Article]Biol Pharm Bull. 2023; 46(2):338-342.BP
- Morphinone (MO) is an electrophilic metabolite of morphine that covalently binds to protein thiols via its α,β-unsaturated carbonyl group, resulting in toxicity in vitro and in vivo. Our previous studies identified a variety of redox signaling pathways that are activated during electrophilic stress. Here, we examined in vitro activation of a signaling pathway involving Kelch-like ECH-associated p…
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- Activation of HSP90/HSF1 Signaling as an Adaptive Response to an Electrophilic Metabolite of Morphine. [Journal Article]Biol Pharm Bull. 2023; 46(2):334-337.BP
- Morphinone (MO) is an electrophilic metabolite of morphine that covalently binds to protein thiols, resulting in toxicity in vitro and in vivo. We have previously identified a variety of redox signaling pathways that are activated during electrophilic stress. However, the role of MO in such activation remains unknown. In this study, we examined whether MO could activate heat shock protein (HSP) 9…
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- [Survey of Prophylactic Administration of Naldemedine for Opioid-induced Constipation]. [Journal Article]Yakugaku Zasshi. 2023; 143(2):183-189.YZ
- Opioid-induced constipation (OIC), an adverse event that occurs due to opioid analgesics, reportedly causes poor quality of life and adherence to opioid analgesics in patients. Therefore, this issue must be addressed appropriately. Naldemedine (NAL), a peripherally-acting μ-opioid receptor antagonist, is currently recommended for treating OIC when other laxatives are ineffective, but there have b…
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- Prior authorization restrictions on medications for opioid use disorder: trends in state laws from 2005 to 2019. [Journal Article]Ann Med. 2023 Dec; 55(1):514-520.AM
- CONCLUSIONS: The number of states with an MOUD prior authorization law prohibition increased in recent years. Such laws could help expand access to life-saving OUD treatments by making it easier for clinicians to prescribe MOUD.KEY MESSAGESNo states had MOUD prior authorization prohibitions between 2005 and 2015 in state statutes or regulations, and only one state had such a prohibition in 2016.By 2019, fifteen states had an MOUD prior authorization prohibition law.States varied significantly in their approach to prohibiting MOUD prior authorization, including with respect to the insurer type, duration of the prohibition, and applicable medication.
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- Short-term recovery after NovaSure® endometrial ablation: a prospective cohort study. [Journal Article]Facts Views Vis Obgyn. 2022 Dec; 14(4):299-307.FV
- CONCLUSIONS: Women undergoing endometrial ablation can be informed that most will fully recover within the first week of the procedure and that there is no difference in expected recovery time according to whether the procedure is undertaken with local anaesthesia or conscious sedation.
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