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333 results
  • Nitroreduction of flutamide by Cunninghamella elegans NADPH: Cytochrome P450 reductase. [Journal Article]
    Biochem Biophys Rep. 2022 Mar; 29:101209.Khan MF, Murphy CD
  • The microbial model of mammalian drug metabolism, Cunninghamella elegans, has three cytochrome P450 reductase genes in its genome: g1631 (CPR_A), g4301 (CPR_B), and g7609 (CPR_C). The nitroreductase activity of the encoded enzymes was investigated via expression of the genes in the yeast Pichia pastoris X33. Whole cell assays with the recombinant yeast demonstrated that the reductases converted t…
  • Polymorphic forms of antiandrogenic drug nilutamide: structural and thermodynamic aspects. [Journal Article]
    Phys Chem Chem Phys. 2021 Apr 28; 23(16):9695-9708.Surov AO, Voronin AP, … Balasubramanian S
  • Attempts to obtain new cocrystals of nonsteroidal antiandrogenic drug nilutamide produced alternative polymorphic forms of the compound (Form II and Form III) and their crystal structures were elucidated by single-crystal X-ray diffraction. Apart from the cocrystallization technique, lyophilization was found to be an effective strategy for achieving polymorph control of nilutamide, which was diff…
  • Role of Polymer Excipients in the Kinetic Stabilization of Drug-Rich Nanoparticles. [Journal Article]
    ACS Appl Bio Mater. 2020 Oct 19; 3(10):7243-7254.Van Zee NJ, Hillmyer MA, Lodge TP
  • Amorphous solid dispersions (ASDs) of crystallizable drugs and polymer excipients are attractive for enhancing the solubility and bioavailability of hydrophobic drug molecules. In this study, the solution behavior of poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) (PND) and poly(vinylpyrrolidone-co-vinylacetate) (PVPVA), as polymer excipients, and nilutamide (NLT), phenytoin (PHY), and itra…
  • Substrate selectivity of human aldehyde oxidase 1 in reduction of nitroaromatic drugs. [Journal Article]
    Arch Biochem Biophys. 2018 12 01; 659:85-92.Ogiso T, Fukami T, … Nakajima M
  • Human aldehyde oxidase 1 (AOX1) catalyzes the oxidation of various drugs and endogenous compounds. Recently, we found that AOX1 catalyzed the reduction of drugs such as nitrazepam and dantrolene. In this study, we aimed to clarify the substrate selectivity of human AOX1 for the reduction of nitroaromatic drugs to obtain helpful information for drug development. We investigated whether 11 nitroaro…
  • Androgen Receptor Targeted Treatments of Prostate Cancer: 35 Years of Progress with Antiandrogens. [Review]
    J Urol. 2018 11; 200(5):956-966.Crawford ED, Schellhammer PF, … Labrie F
  • CONCLUSIONS: Antiandrogens have already provided important benefits for prostate cancer treatment. Greater knowledge about the structural and functional biology of the androgen receptor in prostate cancer will facilitate further discovery and development of further improved antiandrogens with enhanced clinical activity in patients with advanced metastatic disease. Testing these new agents earlier in the course of prostate cancer may further improve the survival and quality of life of patients with current local and/or systemic treatment modalities.
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