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7,604 results
  • Repurposing some of the Well-Known Non-Steroid Anti-Inflammatory Drugs [Nsaids] for Cancer Treatment. [Journal Article]
    Curr Top Med Chem. 2023 Jan 30 [Online ahead of print]Sousa SM, Xavier CPR, … Palmeira A
  • Drug repurposing is a strategy used to develop new treatments based on approved or investigational drugs outside the scope of their original clinical indication. Since this approach benefits from the original toxicity data of the repurposed drugs, the drug-repurposing strategy is time-saving, and inexpensive. It has a higher success rate compared to traditional drug discovery. Several repurposing…
  • Pharmacokinetic and Pharmacodynamic Herb-Drug Interactions of Common Over-the-Counter Pain Medications. [Review]
    Biomed Chromatogr. 2023 Jan 29 [Online ahead of print]Sun CK, Tsai TH
  • Pain is one of the most common reasons for seeking medical intervention, and self-medication with over-the-counter medications and/or traditional herbal remedies has become increasingly popular. In this review, original articles on understanding possible herb-drug interaction between traditional herbs and four major pain medication: acetaminophen, aspirin, ibuprofen, and naproxen were compiled an…
  • Recent Advances in Asymmetric Catalysis Associated with B(C6F5)3. [Review]
    Molecules. 2023 Jan 08; 28(2)Zhan Z, Yan J, … Shi L
  • The prevalence and significance of asymmetric catalysis in the modern medicinal industry has been witnessed in recent years, which have already been used to manufacture the (S)-Naproxen and the (S)-Propranolol. With matched specificities such as the Lewis acidity and steric bulk, B(C6F5)3 has gained accelerating attention on its application in asymmetric catalysis of Diels-Alder cycloaddition rea…
  • Clinician's dilemma: Naproxen-induced liver injury. [Case Reports]
    Indian J Pathol Microbiol. 2023 Jan-Mar; 66(1):168-170.Sharma S, Sharma A, … Bansal N
  • Naproxen is a widely used nonsteroidal anti-inflammatory drug (NSAID) in pediatric population, used for mild-to-moderate pains, arthritis, and other immune-mediated disorders. It rarely causes clinically apparent liver injury in the adult population taking high doses of the drug over a prolonged period and is reported even rarer in pediatric population. We present a case of drug-induced liver inj…
  • Biotinylated Pt(IV) prodrugs with elevated lipophilicity and cytotoxicity. [Journal Article]
    Dalton Trans. 2023 Jan 24; 52(4):866-871.Spector D, Erofeev A, … Krasnovskaya O
  • A design of Pt(IV) prodrugs with tumor cell targeting moieties leading to increased selectivity is of interest. Herein, we designed a novel Pt(IV) prodrugs with COX-inhibitor naproxen, long-chain hydrophobic stearic acid moiety and biotin as axial ligands. We have established that for Pt(IV) prodrugs with biotin and naproxen or stearate in axial position, the lipophilicity rather than biotin rece…
  • An Observational Study of Fixed Drug Eruption in A Tertiary Care Hospital in Bangladesh. [Journal Article]
    Mymensingh Med J. 2023 Jan; 32(1):49-53.Jannat T, Uddin J, … Sumi SA
  • Fixed drug eruption (FDE) is a distinctive pattern of cutaneous adverse drug reaction. Characteristically the eruption recurs at the same site on re exposure to the offending agent. Aim of this study was to evaluate and identification of the various offending drugs causing FDE which may help the physician to limit the associate complication regarding the drug. This observational cross sectional s…
  • Novel management of granuloma formation secondary to dermal filler: A multi-modality approach. [Journal Article]
    J Cosmet Dermatol. 2022 Dec 25 [Online ahead of print]Bowles A, Ghalili S, … Aguilera SB
  • CONCLUSIONS: GFBR provides both a medical and aesthetic issue for these patients including mental distress, pain, and dysfunction, therefore having an effective treatment for GFBR will affect medical management of these patients, improving patient outcomes and satisfaction. Our proposed regimen for GFBR has been shown to be highly efficacious and safe for these patients, providing a significant improvement in both function and cosmesis of the area.
  • Current and emerging COX inhibitors for treating postoperative pain following oral surgery. [Journal Article]
    Expert Opin Pharmacother. 2023 Jan 04 [Online ahead of print]Pergolizzi JV, Breve F, … Varassi G
  • The numerous drugs in the NSAID class are often used to treat acute postoperative pain associated with oral surgery such as impacted third-molar extractions. These drugs are effective in this setting and dental pain studies often serve as models for acute pain relief and for registration of analgesics. With numerous cyclooxygenase (COX) inhibitors available as monotherapy, for use in combination …
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