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565 results
  • Elicitation of Hyoscyamine Production in Datura stramonium L. Plants Using Tobamoviruses. [Journal Article]
    Plants (Basel). 2022 Dec 01; 11(23)Mihálik D, Hančinský R, … Kraic J
  • Datura stramonium L. produces tropane alkaloids, and the hyoscyamine is dominant among them. Hyoscyamine is produced by hairy root cultures in vitro derived from native plants or plants with the genetically modified biosynthetic pathway for hyoscyamine. A common procedure is extraction from cultivated plants. Elicitors for increased production can be used in both cases. Live viruses are not well …
  • Discovery and Engineering of the Cocaine Biosynthetic Pathway. [Journal Article]
    J Am Chem Soc. 2022 12 07; 144(48):22000-22007.Wang YJ, Huang JP, … Huang SX
  • Cocaine, the archetypal tropane alkaloid from the plant genus Erythroxylum, has recently been used clinically as a topical anesthesia of the mucous membranes. Despite this, the key biosynthetic step of the requisite tropane skeleton (methylecgonone) from the identified intermediate 4-(1-methyl-2-pyrrolidinyl)-3-oxobutanoic acid (MPOA) has remained, until this point, unknown. Herein, we identify t…
  • StatPearls: Plant Alkaloids Toxicity [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)VezikovLisa V.LVLake Erie College of Osteopathic Medicine, Greensburg, PASimpsonMichaelMHarvard Medical SchoolBOOK
  • Plant chemistry and toxicology are complex with a rich history. Much about plant chemistry remains unknown, and our understanding relies on animal research combined with documented human experiences. The dynamic science of pharmacognosy, which highlights the therapeutic value of plants, has elucidated several major classes of organic molecules found in plants, of which alkaloids represent one. Ot…
  • Biotechnological Approaches on Engineering Medicinal Tropane Alkaloid Production in Plants. [Review]
    Front Plant Sci. 2022; 13:924413.Gong H, He P, … Liao Z
  • Hyoscyamine and scopolamine, belonging to medicinal tropane alkaloids (MTAs), are potent anticholinergic drugs. Their industrial production relies on medicinal plants, but the levels of the two alkaloids are very low in planta. Engineering the MTA's production is an everlasting hot topic for pharmaceutical industry. With understanding the MTA's biosynthesis, biotechnological approaches are establ…
  • Assessment of the Conclusions of the Joint FAO/WHO Expert Meeting on Tropane Alkaloids. [Journal Article]
    EFSA J. 2022 Apr; 20(4):e07229.European Food Safety Authority (EFSA), Binaglia M
  • The European Food Safety Authority (EFSA) was requested to assess the differences in the outcome of the risk assessment of tropane alkaloids (TAs) in food between the CONTAM Panel and the Joint FAO/WHO meeting (FAO/WHO) and to conclude if an update of the EFSA opinion on tropane alkaloids in food and feed would be appropriate. TAs are secondary metabolites occurring in several plants. The main TA…
  • Acute Poisoning With Datura stramonium Plant Seeds in Qatar. [Case Reports]
    Cureus. 2021 Dec; 13(12):e20152.Shebani A, Hnish M, … Ganaw A
  • Datura stramonium (also called thorn apple or Jimson weed) is a plant that contains atropine, scopolamine, and hyoscyamine, giving it anticholinergic effects when consumed. We report the case of a 32-year-old male in Qatar who intentionally ingested seeds from Jimson weed mixed with milk. The patient became severely confused and delirious, eventually requiring admission to the intensive care unit…
  • Fluorescence-based immunochromatographic test strip for the detection of hyoscyamine. [Journal Article]
    Analyst. 2022 Jan 17; 147(2):293-302.Xu X, Ge W, … Kuang H
  • Hyoscyamine (HSM), which acts as an antagonist of the acetylcholine muscarinic receptor and can induce a variety of distinct toxic syndromes in mammals (anti-cholinergic poisoning), is hazardous to human health. Therefore, it is urgent to develop a rapid, sensitive, and cost-effective method to determine HSM. A fluorescent microsphere based immunochromatographic assay was developed for this analy…
  • Tropane alkaloids and terpenes synthase genes of Datura stramonium (Solanaceae). [Journal Article]
    PeerJ. 2021; 9:e11466.Velázquez-Márquez S, De-la-Cruz IM, … Núñez-Farfán J
  • CONCLUSIONS: Our results indicate differences in the number of gene copies involved in the synthesis of tropane alkaloids, between the genomes of D. stramonium from two Mexican populations. More copies of genes related to the synthesis of tropane alkaloids (TRI, TRII, H6H, PMT) are found in D. stramonium as compared to Viridiplantae. Likewise, for terpene synthases (TPS), TPS-10 is duplicated in D. stramonium and D. metel. Further studies should be directed to experimentally assess gain (overexpression) or loss (silencing) of function of duplicated genes.
  • Antispasmodics for Chronic Abdominal Pain: Analysis of North American Treatment Options. [Review]
    Am J Gastroenterol. 2021 08 01; 116(8):1587-1600.Brenner DM, Lacy BE
  • Chronic abdominal pain is a common gastrointestinal (GI) symptom that characterizes many functional GI disorders/disorders of gut-brain interaction, including irritable bowel syndrome, functional dyspepsia, and centrally mediated abdominal pain syndrome. The symptoms of abdominal pain in these highly prevalent disorders are often treated with antispasmodic agents. Antispasmodic treatment includes…
  • Alkaloids of the Genus Datura: Review of a Rich Resource for Natural Product Discovery. [Review]
    Molecules. 2021 Apr 30; 26(9)Cinelli MA, Jones AD
  • The genus Datura (Solanaceae) contains nine species of medicinal plants that have held both curative utility and cultural significance throughout history. This genus' particular bioactivity results from the enormous diversity of alkaloids it contains, making it a valuable study organism for many disciplines. Although Datura contains mostly tropane alkaloids (such as hyoscyamine and scopolamine), …
  • Drugs and Lactation Database (LactMed): Atropine [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • No information is available on the use of atropine during breastfeeding. Long-term use of atropine might reduce milk production or milk letdown, but a single systemic or ophthalmic dose is not likely to interfere with breastfeeding. During long-term use, observe for signs of decreased lactation (e.g., insatiety, poor weight gain).
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