- Antibiotic prophylaxis in children undergoing abdominal surgery for neoplastic diseases. [Journal Article]
- IMInfez Med 2018 Jun 01; 26(2):122-125
- Little is known about the effectiveness of antibiotic prophylaxis for prevention of surgical site infections (SSIs) in paediatric abdominopelvic surgical oncology. A retrospective analysis was perfor...
Little is known about the effectiveness of antibiotic prophylaxis for prevention of surgical site infections (SSIs) in paediatric abdominopelvic surgical oncology. A retrospective analysis was performed upon the incidence of SSIs in children receiving a 24-hour antibiotic prophylaxis with cefazolin for abdominopelvic oncological surgery. In all, 145 patients (57% females) with a median age of 4 years underwent surgical procedures for abdominopelvic tumours. No SSIs were detected, despite the various risk factors known to be associated with their occurrence (such as pre- and post- surgical chemotherapy, long hospitalization, intensive care unit admission and drain placement). Cefazolin prophylaxis seems to be safe and effective in preventing SSIs in children undergoing abdominopelvic surgery for oncological diseases.
- Amoxicillin and gentamicin antibiotics treatment adversely influence the fertility and morphology through decreasing the Dazl gene expression level and increasing the oxidative stress. [Journal Article]
- APArch Physiol Biochem 2018 Jun 20; :1-9
- The present study was designed to explain the impact of amoxicillin, gentamicin, and cefazolin on the oxidative stress (OS) and reproductivity in the mouse testes. Our data showed that reduced glutat...
The present study was designed to explain the impact of amoxicillin, gentamicin, and cefazolin on the oxidative stress (OS) and reproductivity in the mouse testes. Our data showed that reduced glutathione (GSH) level, which is a marker for OS, strikingly reduced and hydrogen peroxide (H2O2) level, which acts as a signaling molecule in mammalian germ cells, strikingly increased with amoxicillin, gentamicin, and cefazolin treatment. The gene expression and enzymatic activity of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PD), and glutathione-S-transferases (GST) were significantly affected in the presence of these antibiotics. Also, spermatogenesis was adversely affected by suppressing Deleted in Azoospermia (Dazl) gene expression. Finally, oxidative stress and spermatogenesis failure distorted to sperm viability, motility, and morphology in amoxicillin and gentamicin-treated mice.
- Intravenous cefazolin plus oral probenecid versus oral cephalexin for the treatment of skin and soft tissue infections: a double-blind, non-inferiority, randomised controlled trial. [Journal Article]
- EMEmerg Med J 2018 Jun 18
- CONCLUSIONS: Cephalexin at appropriate doses appears to be a safe and effective alternative to outpatient parenteral cefazolin in the treatment of uncomplicated mild-moderate SSTIs who present to the ED.
- Perioperative Anaphylaxis Including Kounis Syndrome due to Selective Cefazolin Allergy. [Journal Article]
- IAInt Arch Allergy Immunol 2018 Jun 18; :1-5
- CONCLUSIONS: Cefazolin can be responsible for immediate severe allergic reactions in perioperative setting, including KS. Allergological workup is essential for an accurate diagnosis and to explore cross-reactivity between cefazolin and other beta-lactams. Our experience confirmed that patients with IgE-mediated hypersensitivity reactions to cefazolin can tolerate other beta-lactams. This selective pattern of clinical reactivity may be explained by its particular chemical structure, whose R1 side-chain is different from other beta-lactams.
- Fecal carriage of multidrug-resistant Escherichia coli by community children in southern Taiwan. [Journal Article]
- BGBMC Gastroenterol 2018 Jun 15; 18(1):86
- CONCLUSIONS: The prevalence of the fecal carriage of nonsusceptible E. coli in children was high; among these E. coli, 37% were MDR, 18.5% were nonsusceptible to ciprofloxacin, and 8.3% produced ESBL. O25b-ST131 was the most common ESBL-producing E. coli clonal group present in the feces of children, and the ESBL and ciprofloxacin-nonsusceptible groups showed significantly higher rates of O25b-ST131 positivity.
- Kounis syndrome caused by anaphylaxis without skin manifestations after cefazolin administration. [Journal Article]
- JAJ Allergy Clin Immunol Pract 2018 Jun 11
- Staphylococcus-Associated Glomerulonephritis Mimicking Henoch-Schönlein Purpura and Cryoglobulinemic Vasculitis in a Patient With an Epidural Abscess: A Case Report and Brief Review of the Literature. [Journal Article]
- CJCan J Kidney Health Dis 2018; 5:2054358118776325
- Staphylococcus-associated glomerulonephritis (SAGN) is a rare immune complex-mediated glomerulonephritis associated with active Staphylococcus infection. We report a case illustrating the importance ...
Staphylococcus-associated glomerulonephritis (SAGN) is a rare immune complex-mediated glomerulonephritis associated with active Staphylococcus infection. We report a case illustrating the importance of clinical history and kidney biopsy findings in establishing the correct diagnosis.
- Cefazolin Induced Liver Injury and Hypoprothrombinemia. [Journal Article]
- JCJ Clin Exp Hepatol 2018; 8(2):213-214
- The Prevalence of a Cefazolin Inoculum Effect Associated with blaZ Gene Types Among Methicillin-Susceptible Staphylococcus aureus Isolates from Four Major Medical Centers in Chicago. [Journal Article]
- AAAntimicrob Agents Chemother 2018 Jun 11
- Cefazolin efficacy with high inoculum methicillin-susceptible Staphylococcus aureus (MSSA) infections remains in question due to therapeutic failure inferred from an inoculum effect. This study inves...
Cefazolin efficacy with high inoculum methicillin-susceptible Staphylococcus aureus (MSSA) infections remains in question due to therapeutic failure inferred from an inoculum effect. This study investigated the local prevalence of a cefazolin inoculum effect (CInE) and its association with staphylococcal blaZ gene types among MSSA isolates in the Chicago area. Four medical centers in Chicago, Illinois contributed MSSA isolates. Cefazolin MICs (C-MIC) were determined at 24 hours by broth microdilution method using standard inocula (SI, 5 x 105 CFU/mL) and high inocula (HI, 5 x 107 CFU/mL). The CInE was defined as 1) a ≥ 4-fold increase in C-MIC between SI and HI and/or 2) a pronounced CInE: a nonsusceptible C-MIC of ≥ 16 μg/mL at HI. PCR was used to amplify the blaZ gene, followed by agarose gel electrophoresis and sequencing to determine the gene type. Approximately 269 MSSA isolates were included. All but one isolate was susceptible to cefazolin at SI and 97% remained susceptible at HI. A total of 196 isolates (73%) were blaZ-positive, led by gene type C (40%). The CInE was seen in 45 blaZ-positive isolates (23%) with 44 (22%) presenting a ≥ 4-fold increase in C-MIC (SI to HI) and five (3%) with a pronounced CInE. Four out of the five, met both definitions of CInE with two expressing the type A gene. The prevalence of a pronounced CInE associated with the type A blaZ gene from MSSA isolates in Chicago is low. Our predilection for cefazolin use, even early in the management of hospitalized MSSA infections, is tenable.
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- Potentially clinically relevant concentrations of Cefazolin, Midazolam, Propofol, and Sufentanil in auto-transfused blood in congenital cardiac surgery. [Journal Article]
- JCJ Cardiothorac Surg 2018 Jun 08; 13(1):64
- CONCLUSIONS: Depending on the drug, up to 34% of the drug concentration salvaged from the operation site is returned to the patient through autotransfusion, potentially causing unwanted drug reactions post-operatively. Additionally, influence of a cellsaver system should be considered in pharmacological research during and after congenital cardiac surgery and could result in dose adjustments in the postoperative phase.