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6,054 results
  • In vitro and Ex vivo Assessments of the Compatibility of Fibrin Sealant with Antimicrobial Compounds. [Journal Article]
    Surg Infect (Larchmt). 2023 Feb; 24(1):82-90.Strickland AD, Lang C, … Slezak P
  • Background: Fibrin sealants are used as antimicrobial-releasing carriers for preventing surgical site infections; however, it is important to determine the release kinetics and antimicrobial effects of drugs added to fibrin sealants and the effects of drugs on clot/clotting properties. Materials and Methods: The antimicrobial and antibiofilm activity of cefazolin, colistin, gentamicin, oxacillin,…
  • Perioperative Antibiotic Prophylaxis in Pediatric Cardiac Surgery-Simple Is Better. [Journal Article]
    Antibiotics (Basel). 2022 Dec 30; 12(1)Burzyńska J, Jaworski R, … Dzierżanowska-Fangrat K
  • Pediatric cardiac surgery requires perioperative antibiotic prophylaxis (PAP) to reduce the risk of surgical site infections. However, the complexity of these procedures and the metabolic immaturity of children impede the establishment of PAP regimens that are both efficacious and in line with antimicrobial stewardship (AMS). In this study, we compared two PAP regimens: cefazolin with gentamicin …
  • Access to medicines for children in China. [Review]
    BMJ Paediatr Open. 2022 Dec; 6(1)Chen Z, Li S, … Zhang L
  • Access to essential medicines for children is a big challenge, particularly in low-income and middle-income countries. In China, the average availability of essential medicines for children is 1.6%-46.5%. The availability of generics was generally higher than original brands in public hospitals and the prices of generics were relatively lower and more reasonable (generics: availability, 27.3%-46.…
  • Severe Cholestatic Drug-Induced Liver Injury With Cephalosporin Use. [Case Reports]
    Cureus. 2022 Dec; 14(12):e32262.Yang K, Moga T, … Mahl T
  • Drug-induced liver injury (DILI) is a phenomenon that occurs with nearly all classes of medications. Cholestatic DILI represents a fraction of these cases and can present as bland cholestasis, cholestatic hepatitis, secondary sclerosis cholangitis, and vanishing bile duct syndrome. Risk factors have been identified for cholestatic DILI, including older age, genetic determinants, and certain medic…
  • Current Status of Outpatient Parenteral Antimicrobial Therapy in Korea: Experience of a Single University-Affiliated Acute-Care Hospital. [Journal Article]
    Infect Chemother. 2022 Dec 16 [Online ahead of print]Heo E, Choi Y, … Song KH
  • CONCLUSIONS: We found that a significant number of OPATs were prescribed, follow-up visits were not performed in the case of about a quarter of prescriptions, and laboratory monitoring was not fully conducted in more than half of the cases. Therefore, it is necessary to establish an appropriate management program for OPAT. Considering the limited resources and the distribution of OPAT prescriptions, an effective strategy may be to select the frequently-used antibiotics or frequently-prescribing departments and start the program with them.
  • No more tears from surgical site infections in interventional pain management. [Review]
    Korean J Pain. 2023 Jan 01; 36(1):11-50.Lim S, Yoo YM, Kim KH
  • As the field of interventional pain management (IPM) grows, the risk of surgical site infections (SSIs) is increasing. SSI is defined as an infection of the incision or organ/space that occurs within one month after operation or three months after implantation. It is also common to find patients with suspected infection in an outpatient clinic. The most frequent IPM procedures are performed in th…
  • Prevalence and characteristics of antibiotic prescription for acute COVID-19 patients in Japan. [Journal Article]
    Sci Rep. 2022 12 26; 12(1):22340.Hamada S, Tokuda Y, … Shibuya K
  • COVID-19 is a viral infection and does not require antibiotics. The study aimed to elucidate a prescribing pattern of antibiotics for COVID-19. A nationwide cross-sectional study was conducted in Japan. The Diagnosis and Procedure Combinations (DPC) data was used to collect information, covering 25% of all acute care hospitals in the country. In 140,439 COVID-19 patients, 18,550 (13.21%) patients…
  • Reversible cefazolin-induced status epilepticus in a peritoneal dialysis patient. [Case Reports]
    Toxicol Rep. 2022; 9:1950-1952.Chen CC, Lee DJ, Lin SH
  • Cefazolin-induced neurotoxicity with the documented toxic concentration has not been reported in uremic patients on continuous ambulatory peritoneal dialysis (CAPD). We described an elderly female on CAPD for years presented with newly-onset status epilepticus. Her body weight was 60 kg. And she had received intraperitoneal ceftazidime and cefazolin 1.5 g once daily for her CAPD peritonitis 5 day…
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