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4,932 results
  • Local Versus Systemic Antibiotics for Surgical Infection Prophylaxis in a Rat Model. [Journal Article]
  • JBJ Bone Joint Surg Am 2018 Sep 19; 100(18):e120
  • Sweet FA, Forsthoefel CW, … Dahlberg RK
  • CONCLUSIONS: Local antimicrobial prophylaxis with vancomycin and tobramycin powder for infections in the rat model was statistically superior to systemic prophylaxis with IV antibiotics, local cefazolin powder, and Betadine lavage.This study supports the findings of prior clinical reports that intrawound vancomycin powder reduces the risk of surgical site infection. Local application of tobramycin powder was equivalent to vancomycin powder in this model. Additionally, the superiority of local antibiotic surgical prophylaxis suggests that clinical studies should be considered to determine the relative efficacy of local versus systemic antibiotics for surgical infection prophylaxis in humans.
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