- Oxidative Stress Mediated by N6-Methyladenosine Methylation Contributes to High-Fat Diet Induced Male Reproductive Dysfunction. [Journal Article]Mol Nutr Food Res. 2023 Feb 03 [Online ahead of print]MN
- CONCLUSIONS: Oxidative stress mediated by methylation of m6A may contribute to high fat diet-induced male reproductive dysfunction. This article is protected by copyright. All rights reserved.
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- The effects of Ginger (Zingiber officinale) roots on the reproductive aspects in male Japanese Quails (Coturnix coturnix japonica). [Journal Article]BMC Vet Res. 2023 Feb 03; 19(1):34.BV
- CONCLUSIONS: Ginger roots especially at a dose of 15 gm/kg feed was effective in improving male reproductive performance. These findings are of utmost importance in encouraging the addition of Ginger roots in ration formulation in male quails.
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- Changes in testosterone levels after inadequate solar light. [Letter]Asian J Surg. 2023 Feb 01 [Online ahead of print]AJ
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- An Online Investigation into Direct-to-Consumer Men's Health Clinics: The Who, What and Where. [Journal Article]Urology. 2023 Feb 01 [Online ahead of print]U
- CONCLUSIONS: There is significant heterogeneity and misinformation available to the public regarding men's health. Familiarity with and insight into practice patterns of "men's health" clinics will help provide informed patient care and counseling.
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- Monorchidism in a phenotypic mare with a 64,XY, SRY-positive karyotype. [Case Reports]J Equine Vet Sci. 2023 Feb 01 [Online ahead of print]JE
- Disorders of sexual development (DSD) are associated with atypical chromosomal, gonadal, or phenotypic sex. It is likely that the number of cases of DSD are underestimated in the equine population. Monorchidism in the horse is very rare. This case report describes the clinical assessment of a phenotypic mare with stallion-like behavior which led to the diagnosis of a DSD. A 4-year-old Quarter Hor…
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- The role of N6-methyladenosine modification in benzene-induced testicular damage and the protective effect of melatonin. [Journal Article]Chemosphere. 2023 Jan 31 [Online ahead of print]C
- Benzene is a universal ambient pollutant. Population-based studies have shown that benzene exposure affects male fertility. However, the mechanism of benzene-induced reproductive toxicity is unknown. Here, we established a dynamic inhalation model and exposed C57BL/6J mice to 0, 10, and 50 ppm benzene (6 h/day, 6 days/week, 7 weeks). Our study revealed that benzene exposure caused testicular inju…
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- Maternal phthalate exposure during pregnancy and testis function of young adult sons. [Journal Article]Sci Total Environ. 2023 Jan 31 [Online ahead of print]ST
- CONCLUSIONS: In this exploratory study, higher maternal exposure to some phthalates was associated with impaired testicular Leydig cell function evidenced by a lower total and free testosterone/LH ratio in adult sons. This unique 18-20-year follow-up study raises concern and suggests that exposure of pregnant women to phthalates may have long-term effects on adult reproductive health in male offspring.
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- Effects of testis testosterone deficiency on gene expression in the adrenal gland and skeletal muscle of ducks. [Journal Article]Br Poult Sci. 2023 Feb 03 [Online ahead of print]BP
- Testosterone has an anabolic effect on skeletal muscle. The testes produce most of the testosterone in vivo, while the adrenal glands contribute smaller amounts. When testis testosterone is deficient the adrenal gland increases steroid hormone synthesis, which is referred to as compensatory testicular adaptation (CTA).To reveal the effects of testis testosterone deficiency on adrenal steroid horm…
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- Urinary Tract Infections Among Gender Diverse People Assigned Female at Birth on Testosterone. [Journal Article]Urogynecology (Hagerstown). 2023 Feb 01; 29(2):295-301.U
- CONCLUSIONS: The rate of UTIs among our young cohort of GDT and CW was similarly low. Diabetes mellitus type 1 or 2 was significantly associated with UTIs among CW but not GDT. These findings suggest that testosterone-induced vaginal atrophy may not be associated with a higher a UTI risk. A deeper understanding of the pathogenesis of UTI in people assigned female at birth and more data on the relationship between testosterone and UTIs are needed before recommending vaginal estrogen to all GDT with recurrent UTI.
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- Do testosterone and cortisol levels moderate aggressive responses to peer victimization in adolescents? [Journal Article]Dev Psychopathol. 2023 Feb 03 [Online ahead of print]DP
- Aggressive reactions to peer victimization may be tempered by hormone levels. Grounded on the dualhormone hypothesis (DHH), which proposes that testosterone (T) is associated with aggressive behavior only when cortisol (C) is low, this study assessed whether the combination of T and C moderated adolescents' aggressive responses to peer victimization. The study involved 577 adolescents (50.4% girl…
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- Nomogram based on a circular RNA biomarker for predicting the likelihood of successful sperm retrieval via microdissection testicular sperm extraction in patients with idiopathic non-obstructive azoospermia. [Journal Article]Front Endocrinol (Lausanne). 2022; 13:1109807.FE
- CONCLUSIONS: circ_MGLL is significantly associated with the SRO of micro-TESE in patients with iNOA. The circ_MGLL-based nomogram developed in the current study can predict successful SRO with high accuracy.
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- Fertility-associated biochemical components in seminal plasma and serum of buffalo (Bubalus bubalis) bulls. [Journal Article]Front Vet Sci. 2022; 9:1043379.FV
- The present study looks for components in seminal plasma (SP) and/or serum that are closely related to in vivo fertility of buffalo bulls. Fourteen healthy mature buffalo bulls were classified according to their in vivo fertility into fertile (n = 10) and subfertile (n = 4) groups. Semen and serum samples were collected from all animals for 12 replicates. The collected ejaculates were examined fo…
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- The effects of a low carbohydrate diet on erectile function and serum testosterone levels in hypogonadal men with metabolic syndrome: a randomized clinical trial. [Journal Article]BMC Endocr Disord. 2023 Feb 02; 23(1):30.BE
- CONCLUSIONS: Low carbohydrate diet may increase serum levels of testosterone and improve erectile function in hypogonadal men with metabolic syndrome. However, larger studies are necessary to strongly prove the effectiveness of low carbohydrate diet in treating male hypogonadism.
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- Effects of time-restricted feeding on letrozole-induced mouse model of polycystic ovary syndrome. [Journal Article]Sci Rep. 2023 Feb 02; 13(1):1943.SR
- The present study aimed to investigate whether time-restricted feeding (TRF) ameliorates metabolic and reproductive phenotypes in a letrozole-induced mouse model of polycystic ovary syndrome (PCOS). Sixty female C57BL/6 N mice were randomly divided into two groups according to the type of food received: either a chow or a 60% high-fat diet. Those mice were subcutaneously implanted with letrozole …
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- Artificial Intelligence-Augmented Electrocardiogram in Determining Sex: Correlation with Sex Hormone Levels. [Journal Article]Mayo Clin Proc. 2023 Jan 31 [Online ahead of print]MC
- CONCLUSIONS: In this study, TT levels were lower and E2 levels higher with decreasing AI-ECG male probability in both sexes. Male and female patients with discordant AI-ECG sex probability had significantly different TT or E2 levels. This suggests that the ECG could be used as a biomarker of hormone status.
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- Day-to-day coordination of the stress and reproductive axes: a continuous-time analysis of within-person testosterone and cortisol relationships in athletic and healthy men. [Journal Article]Physiol Behav. 2023 Jan 30 [Online ahead of print]PB
- Day-to-day coordination of the stress (i.e., hypothalamic-pituitary-adrenal [HPA]) and reproductive (i.e., hypothalamic-pituitary-gonadal [HPG]) axes is central to allostatic regulation, reproductive success, and survival. Reports of positive, within-person testosterone and cortisol relationships (or coupling) suggest cross-talk of a facilitative nature, but longitudinal evidence is scarce and ha…
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- Testosterone and Cortisol Salivary Samples Are Stable Across Multiple Freeze-Thaw Cycles. [Journal Article]J Strength Cond Res. 2022 Nov 17 [Online ahead of print]JS
- Sontag, SA, Cabarkapa, D, and Fry, AC. Testosterone and cortisol salivary samples are stable across multiple freeze-thaw cycles. J Strength Cond Res XX(X): 000-000, 2022-When processing salivary samples for biomarker analysis, avoiding multiple freeze-thaw cycles is generally recommended. However, confusing tissue handling instructions or challenges with collections in the field sometimes makes t…
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- The sex life of male patients with cirrhosis and its organic factors: What we have got so far? [Journal Article]PLoS One. 2023; 18(2):e0280915.Plos
- CONCLUSIONS: The sex life of cirrhotic men is affected. The decrease in the frequency of intercourse and sexual satisfaction is noticeable in male patients and leads to increased masturbation. Free Testosterone, vitamin D, albumin, and bilirubin play role in their sex life. In addition, ascites and sarcopenia not only affect their sex life but also hamper the quality of their well-being.
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- The influence of manual semen collection in male trained dogs (Canis familiaris), in the presence or absence of a female in estrus, on the concentrations of cortisol, oxytocin, prolactin and testosterone. [Journal Article]PLoS One. 2023; 18(2):e0278524.Plos
- Sex pheromones are chemical substances secreted into the environment that affect the physiology and behavior of recipients. Females use these compounds during oestrus to attract males, which leads to attempts of mating. This study evaluates the influence of manual semen collection in male dogs, in the presence or absence of a female in estrus, on the blood concentrations of cortisol (CRT), oxytoc…
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- Supra-physiological doses of anabolic androgenic steroids impact erythropoietin and blood parameters. [Journal Article]Drug Test Anal. 2023 Feb 02 [Online ahead of print]DT
- Hematological parameters and erythropoiesis are known to be influenced by anabolic androgenic steroid (AAS) use. However, little is known in relation to supra-physiological doses of AAS. Therefore, the aim of this study was to evaluate the effect of supra-physiological doses of AAS on serum and urinary erythropoietin (EPO), and blood parameters, from self-reported AAS users. Serum EPO levels were…
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- The reference value of anti-Müllerian hormone to diagnose polycystic ovary syndrome is inversely associated with BMI: a retrospective study. [Journal Article]Reprod Biol Endocrinol. 2023 Feb 01; 21(1):15.RB
- CONCLUSIONS: AMH is a potential diagnostic indicator of PCOS and is adversely associated with BMI. The AMH cut-off value for diagnosing PCOS was significantly higher than that for PCOM.
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- Association of non-alcoholic fatty liver disease with total testosterone in non-overweight/obese men with type 2 diabetes mellitus. [Journal Article]J Endocrinol Invest. 2023 Feb 01 [Online ahead of print]JE
- CONCLUSIONS: Higher serum TT was significantly associated with a lower prevalence of NAFLD in men with T2DM. We found that the relationship of TT and NAFLD was stronger in individuals with non-overweight/obesity.
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- Dietary trends and the decline in male reproductive health. [Review]Hormones (Athens). 2023 Feb 02 [Online ahead of print]H
- Over the twentieth century, male reproductive health has suffered a substantial decline, as evidenced by decreases in sperm counts and testosterone levels and increases in reproductive pathologies. At the same time, the prevalence of chronic diseases such as obesity, diabetes, and metabolic syndrome has risen dramatically. Metabolic and reproductive health are highly interconnected, suggesting th…
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- Postmenopausal sexual function and steroid hormone levels: a hospital-based cross-sectional study. [Journal Article]Climacteric. 2023 Feb 01 [Online ahead of print]C
- CONCLUSIONS: The main finding of this study is the association of androstenedione with sexual function in postmenopausal women, not verified for other steroid hormones. Further studies are necessary to determine the importance of androstenedione for postmenopausal sexual function.
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- Genetic Variants in SRD5A2 in a Spectrum of DSD Patients from Australian Clinics Highlight Importance of Genetic Testing alongside Typical First-Line Investigations. [Journal Article]Sex Dev. 2023 Feb 01 [Online ahead of print]SD
- CONCLUSIONS: This work highlights the importance of early genetic testing in children born with 46,XY DSD where it complements traditional first-line testing.
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- Gonadotropin administration to mimic minipuberty in hypogonadotropic males: pump or injections? [Journal Article]Endocr Connect. 2023 Feb 01 [Online ahead of print]EC
- CONCLUSIONS: Early postnatal administration of recombinant gonadotropins in CHH boys is effective in stimulating penile growth, Sertoli cell proliferation and testicular descent, with both treatment modalities.
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- Steroid Hormones in Seminal Plasma: the Relationship with Sperm Quality. [Journal Article]Bull Exp Biol Med. 2023 Feb 01 [Online ahead of print]BE
- The purpose of this study was to find out whether the seminal testosterone and/or estradiol levels could serve as prognostic criteria for normal spermatogenesis and whether they are able to characterize the sperm pathology. The study involved healthy young male volunteers (n=269); serum and seminal steroid hormones were measured; the sperm concentration, mobility, and morphology were evaluated. T…
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- Persistence of foetal testicular features in patients with defective androgen signalling. [Journal Article]Eur J Endocrinol. 2023 Jan 31 [Online ahead of print]EJ
- CONCLUSIONS: Androgen signalling may affect the differentiation of adult but possibly not foetal SCs or LCs and may induce a shift of testosterone production from the tubular compartment in the foetal phase to the interstitial compartment in the adult phase.
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- Eight weeks of androgen priming by daily low-dose hCG injections before ICSI treatment in women with low ovarian reserve. [Journal Article]Hum Reprod. 2023 Jan 31 [Online ahead of print]HR
- CONCLUSIONS: The proportion of antral follicles (2-10 mm) that reached the preovulatory state did not increase.The sample size was small, and the number of oocytes retrieved was not the primary endpoint. Larger studies are needed to confirm this finding.Long-term, low-dose rhCG administration may increase the number of oocytes retrieved during IVF/ICSI in women with low ovarian reserve, but more research is needed before firm conclusions can be drawn.
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- Effects of six weeks of sub-plateau cold environment training on physical functioning and athletic ability in elite parallel giant slalom snowboard athletes. [Journal Article]
- CONCLUSIONS: Six weeks of sub-plateau cold environment training may improve physical functioning and promote aerobic and anaerobic capacity for parallel giant slalom snowboard athletes. Furthermore, male athletes had a greater improvement of physical functioning and athletic ability when trained in sub-plateau cold environments.
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