- Developmental programming: Adipose depot-specific regulation of non-coding RNAs and their relation to coding RNA expression in prenatal testosterone and prenatal bisphenol-A -treated female sheep. [Journal Article]Mol Cell Endocrinol. 2023 Jan 25 [Online ahead of print]MC
- Inappropriate developmental exposure to steroids is linked to metabolic disorders. Prenatal testosterone excess or bisphenol A (BPA, an environmental estrogen mimic) leads to insulin resistance and adipocyte disruptions in female lambs. Adipocytes are key regulators of insulin sensitivity and tissue-specific differences in insulin sensitivity, coupled with adipose depot-specific changes in key mR…
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- Genetic variation reveals the influence of steroid hormones on the risk of retinal neurodegenerative diseases. [Journal Article]
- It is difficult to get evidence from randomized trials of a causal relationship between steroid hormones produced by the adrenal gland and gonad and retinal neurodegenerative disorders (RND). In this study, genetic variations of aldosterone (Aldo), androstenedione (A4), progesterone (P4), hydroxyprogesterone (17-OHP), and testosterone/17β-estradiol (T/E2) were obtained from genome-wide associatio…
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- Screening for non-classic congenital adrenal hyperplasia in women: New insights using different immunoassays. [Journal Article]
- CONCLUSIONS: Optimal RIA-based basal 17OHP cutoff was comparable with that recommended in guidelines. The results suggest adopting a higher 17OHP cutoff when using ELISA. LH : FSH ratio improves the negative predictive value of basal 17OHP.
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- Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. [Review]Reprod Biol Endocrinol. 2023 Jan 26; 21(1):10.RB
- CONCLUSIONS: Inositol is an effective and safe treatment in PCOS. Moreover, inositols showed non-inferiority in most outcomes compared to the gold standard treatment; metformin.
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- Potential mechanisms linking high-volume exercise with coronary artery calcification. [Review]Heart. 2023 Jan 26 [Online ahead of print]H
- Recent studies have found an association between high volumes of physical activity and increased levels of coronary artery calcification (CAC) among older male endurance athletes, yet the underlying mechanisms have remained largely elusive. Potential mechanisms include greater exposure to inflammatory cytokines, reactive oxygen species and oxidised low-density lipoproteins, as acute strenuous phy…
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- Studying paraben-induced estrogen receptor- and steroid hormone-related endocrine disruption effects via multi-level approaches. [Journal Article]Sci Total Environ. 2023 Jan 23 [Online ahead of print]ST
- Increasing concerns have been raised on the health risks of parabens in the regard of their widespread applications and potential endocrine disrupting activities. In this study, four typical parabens, including methyl paraben (MeP), ethyl paraben (EtP), propyl paraben (PrP), and butyl paraben (BuP) were systematically investigated for their estrogen receptor- and steroid hormone-related endocrine…
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- Associations of sex-related steroid hormones and proteins with alcohol dependence: A United Kingdom Biobank study. [Journal Article]Drug Alcohol Depend. 2023 Jan 18; 244:109781.DA
- CONCLUSIONS: Testosterone and estradiol levels are altered in males and females with AD distinctly regardless of current drinking frequency. SHBG may play a critical role in these associations.
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- Sex transition from female to male as a risk factor for sleep-disordered breathing. [Journal Article]Sleep Med. 2023 Jan 15; 102:180-185.SM
- CONCLUSIONS: SDB decreases the quality of life and life expectancy of FtM individuals. Their prognosis is undoubtedly better with effective treatment. Hence, obese FtM subjects should be considered at risk and screened for SDB.
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- Examining the Role of Physical Activity Interventions in Modulating Androgens and Cardiovascular Health in Postmenopausal Women: A Narrative Review. [Review]CJC Open. 2023 Jan; 5(1):54-71.CO
- A growing body of literature has examined the role of physical activity (PA) in modifying the effects of estrogen withdrawal on cardiovascular health in postmenopausal women, but the impact of PA on androgens is less clear. Changes in androgen concentrations following regular PA may improve cardiovascular health. This narrative review summarizes the literature assessing the impact of PA intervent…
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- Hormonal abnormalities in alexithymia. [Journal Article]Front Psychiatry. 2022; 13:1070066.FP
- Alexithymia is a personality trait characterized by difficulties in emotion recognition and regulation that is associated with deficits in social cognition. High alexithymia levels are considered a transdiagnostic risk factor for a range of psychiatric and medical conditions, including depression, anxiety, and autism. Hormones are known to affect social-emotional cognition and behavior in humans,…
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- CARBONATED BEVERAGES AFFECT LEVELS OF ANDROGEN RECEPTOR AND TESTOSTERONE SECRETION IN MICE. [Journal Article]Acta Endocrinol (Buchar). 2022 Jul-Sep; 18(3):301-305.AE
- CONCLUSIONS: A high concentration of Coca-Cola and Pepsi-Cola could raise TLD and TDD, enhance testosterone secretion, and increase serum EGF concentrations.
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- GYNAECOMASTIA APPEARED THREE DAYS AFTER STARTING METHIMAZOLE. [Journal Article]Acta Endocrinol (Buchar). 2022 Jul-Sep; 18(3):398-400.AE
- We reported that in a 29-year-old male patient with hyperthyroidism, bilateral breast swelling appeared in three days after starting methimazole and gradually aggravated. Several days later, a small amount of transparent liquid could be squeezed out from bilateral mammary glands. Breast ultrasound confirmed gynaecomastia. The level of testosterone, estradiol and luteinizing hormone increased. Aft…
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- Relationship between body composition, insulin resistance, and hormonal profiles in women with polycystic ovary syndrome. [Journal Article]Front Endocrinol (Lausanne). 2022; 13:1085656.FE
- CONCLUSIONS: Obese and non-obese women with PCOS have more severe insulin resistance and sex-hormone disorders than women without PCOS. The effect of body fat on sex-hormone disorders is only exist in women with PCOS. These findings suggested that PCOS clinical guidelines should be more specific to body fat.
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- Protective effects of hydroalcoholic extract of Rosa canina L. fruit on cyclophosphamide-induced testicular toxicity in mice. [Journal Article]Avicenna J Phytomed. 2023 Jan-Feb; 13(1):7-17.AJ
- CONCLUSIONS: According to our findings, HARF at the doses of 500 and 750 mg/kg inhibited the ruinous effects of CP on the reproductive system in mice.
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- The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction. [Journal Article]J Endocrinol Invest. 2023 Jan 25 [Online ahead of print]JE
- CONCLUSIONS: These are the first guidelines based on a multidisciplinary approach that involves the most important Societies related to the field of sexual medicine. This fruitful discussion allowed for a general agreement on several recommendations and suggestions to be reached, which can support all stakeholders in improving couple sexual satisfaction and overall general health.
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- Citrinin inhibits the function of Leydig cells in male rats in prepuberty. [Journal Article]Ecotoxicol Environ Saf. 2023 Jan 23; 252:114568.EE
- Citrinin, a mycotoxin existing in fruits, has nephrotoxicity, hepatotoxicity and embryotoxicity. The effects of citrinin on Leydig cell development in prepuberty remains unclear. Male Sprague-Dawley rats were gavaged with 0, 1, 2.5, and 5 mg/kg citrinin from postnatal days 21-28. Citrinin at 5 mg/kg significantly decreased serum testosterone levels, while increasing serum LH and FSH levels. Citri…
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- Do correlates of white matter features differ between older men and women living with human immunodeficiency virus? [Journal Article]Menopause. 2023 Feb 01; 30(2):149-155.M
- CONCLUSIONS: Although sexually dimorphic interactions of reproductive hormones and total white matter volume were demonstrated, our study findings do not support a role for sex-based differences in reproductive hormones as predictive correlates of WMH in a small sample of older PLWH.
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- A few certainties about testosterone in women. [Letter]Climacteric. 2023 Jan 25 [Online ahead of print]C
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- Management of genitourinary symptoms in patients with breast cancer: an updated systematic review of available evidence from randomized trials. [Journal Article]Support Care Cancer. 2023 Jan 25; 31(2):131.SC
- CONCLUSIONS: Treatment of GUS remains a challenging issue. It is evident that more prospective trials are needed.
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- Sex-moderated relationship between the 2D:4D ratio and circulating hormones in an adult Ghanaian population. [Journal Article]
- The second-to-fourth digit ratio (2D:4D) is the putative marker of prenatal hormone exposure. The 2D:4D ratio or the right-left difference (Dr-l) are said to be negative and positive correlates, respectively, of circulating testosterone and estrogen in both adult males and females. However, previous studies on the subject have reported mixed results. This study aimed to determine the sex-moderate…
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- Extra virgin olive oil ameliorates high-fat diet-induced seminal and testicular disorders by modulating the cholesterol pathway. [Journal Article]Andrology. 2023 Jan 25 [Online ahead of print]A
- CONCLUSIONS: The combination of HFD with EVOO encourages testicular recovery by modifying the expression of the enzymes related to intracellular cholesterol management. This article is protected by copyright. All rights reserved.
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- Testosterone Replacement Therapy: A Narrative Review with a Focus on New Oral Formulations. [Review]
- Male hypogonadism affects 10-30% of the male population and is often under-recognized and under-treated. Different replacement formulations exist, each with specific benefits and limitations. These replacements include gels, patches and short- and long-acting injectables. JATENZO® (oral testosterone undecanoate; Clarus Therapeutics Inc., Northbrook, IL, US) is the first oral formulation of testos…
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- A Comparative Clinical and Laboratory Study of Adolescent and Adult Acne in Iraqi Women. [Journal Article]
- Background Acne vulgaris is a common chronic inflammatory disease of the pilosebaceous units associated with long-term sequelae and complications. Currently, acne in women is classified into adolescent and post-adolescent forms. However, comparative studies evaluating the clinical and laboratory parameters across various age groups in women with acne are lacking. The aim of the study is to compar…
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- Therapeutic Potential of Selenium Nanoparticles on Letrozole-Induced Polycystic Ovarian Syndrome in Female Wistar Rats. [Journal Article]Biol Trace Elem Res. 2023 Jan 25 [Online ahead of print]BT
- Polycystic ovarian syndrome (PCOS) is considered the most frequent gynecological endocrine disorder that causes anovulatory infertility. The current study aimed to investigate the potential significance of selenium nanoparticles (SeNPs), an IL-1 inhibitor, in the treatment of letrozole-induced PCOS in rats that satisfied the metabolic and endocrine parameters found in PCOS patients. Letrozole (2 …
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- Effect of testosterone therapy on migraine frequency and disability in two transgender patients: a case report. [Case Reports]BMJ Case Rep. 2023 Jan 24; 16(1)BC
- With an increasing number of patients seeking gender-affirming hormone therapy (GAHT), the clinical impact of testosterone treatments on headache needs to be determined. Our case report looks at the potential effect of testosterone on migraine among transgender patients. We present two transmasculine patients who used masculinising hormone therapy with testosterone. Both patients described their …
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- Age-related decrease in serum dihydrotestosterone concentration is accompanied by impaired vascular status. [Journal Article]Exp Gerontol. 2023 Jan 21; 173:112104.EG
- CONCLUSIONS: We have shown that ageing leads to a significant decrease in DHT concentration that is accompanied by impaired arterial wall characteristics and worsened endothelial function. Therefore more attention should be paid to the DHT, DHEA-S and ADG concentrations as a biomarkers for vascular dysfunction in ageing men.
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- Risk of Central Serous Chorioretinopathy in Male Androgen Abusers. [Journal Article]Ophthalmol Ther. 2023 Jan 24 [Online ahead of print]OT
- CONCLUSIONS: Male androgen abusers were not at increased risk of CSC. Considering the lack of any signal in this large study, we speculate that if male androgen plays any direct role in the pathophysiology of CSC, its role may be subtle at best.
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- Expression and Clinical Significance of HIF-1α in Follicular Fluid and Granulosa Cells in Infertile PCOS Patients. [Journal Article]Reprod Sci. 2023 Jan 23 [Online ahead of print]RS
- The present study aimed to determine the clinical predictive significance of HIF-1α in follicular development and assisted reproductive technology (ART). We collected follicular fluid (FF) and granulosa cells (GCs) from PCOS (polycystic ovary syndrome) patients (experimental group) and other patients who were infertile due to tubal factors or male factors (control group) with IVF/ICSI-ET. The loc…
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- Cedrus deodara (Roxb. ex D.Don) G.Don bark fraction ameliorates metabolic, endocrine and ovarian dynamics in rats experiencing polycystic ovarian syndrome. [Journal Article]J Ethnopharmacol. 2023 Jan 21; 306:116206.JE
- CONCLUSIONS: In a nutshell, F1 exhibited promising beneficial effects in PCOS and associated conditions via amelioration of metabolic, endocrine, and ovarian dynamics in experimental rats.
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