- Hypoxia inducible factor-1α promotes trichogenic gene expression in human dermal papilla cells. [Journal Article]Sci Rep. 2023 Jan 27; 13(1):1478.SR
- Dermal papilla cells (DPCs) play critical roles in hair follicle development, but the underlying mechanisms that contribute to hair regeneration have yet to be fully elucidated, particularly in terms of alterations in androgenetic alopecia patients. In this study, we demonstrated that hypoxia-inducible factor-1α (HIF-1α) is suppressed in scalp tissues of androgenetic alopecia patients and potenti…
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- Corrigendum: A community-oriented survey on the association between androgenetic alopecia and metabolic syndrome in Chinese people. [Published Erratum]
- [This corrects the article DOI: 10.3389/fmed.2022.1009578.].
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- Clinical and metabolic characteristics of males with early-onset androgenetic alopecia. [Journal Article]Indian J Dermatol Venereol Leprol. 2022 Dec 07 [Online ahead of print]IJ
- Background Men with early-onset androgenetic alopecia (AGA) often have an abnormal hormonal milieu. Objective To ascertain the clinico-phenotypic characteristics and the prevalence of hormonal and metabolic changes in men with early-onset AGA. Methods Consecutive male patients less than 30 years of age with a Norwood-Hamilton grade ≥3 AGA were recruited in this comparative cross-sectional study. …
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- Pediatric androgenetic alopecia: an updated review. [Review]J Dtsch Dermatol Ges. 2023 Jan 23 [Online ahead of print]JD
- Pediatric androgenetic alopecia is an underrecognized disorder. A clinical evaluation with trichoscopy should be made in children and adolescents with hair loss and/or reduced hair density. Diagnosis is usually clinical, by observation of the hair loss pattern and performance of trichoscopy. In some cases, hyperandrogenism should be excluded. Although there is no approved therapy for androgenetic…
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- Pilot study: genetic distribution of AR, FGF5, SULT1A1 and CYP3A5 polymorphisms in male Mexican population with androgenetic alopecia. [Journal Article]
- Genetics is responsible for 80% of androgenetic alopecia (AGA) predisposition. Several single nucleotide polymorphisms (SNPs) have been linked to AGA risk and the metabolism of its first-line therapies. Genotypic and allelic frequencies have not been described in Mexican individuals; therefore, the aim of this study was to describe the genetic distribution of SNPs associated with AGA predispositi…
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- Oral supplementation in female telogen effluvium: a clinical and instrumental objective evidence of efficacy and tolerability of new oral cosmetic treatment. [Journal Article]Ital J Dermatol Venerol. 2023 Jan 16 [Online ahead of print]IJ
- CONCLUSIONS: The results of our study demonstrate the ability of a new tablet supplement with sulfurate amino acids and trace elements ingredients to effectively and safely improve the hair growth and hair loss in patients with telogen effluvium associated with mild to moderate AGA. The supplement was found to be excellently tolerated from all the patients, safe, and easily incorporated into daily routines.
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- Translation into Spanish Language (México), Transcultural Adaptation, and Validation of the Quality of Life Questionnaire in Female Pattern Hair Loss (WAA-QoL-Sp). [Journal Article]
- CONCLUSIONS: A Spanish version of the WAA-QoL questionnaire was translated and adapted, which proved to be consistent and a valid tool for assessment of FPHL.
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- Efficacy and Safety of Scalp Microneedling in Male Pattern Hair Loss. [Journal Article]
- CONCLUSIONS: Isolated scalp microneedling did not show improvement in scalp coverage or hair density of MPHL participants in this study.
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- Second-to-fourth digit ratio and age predicting the severity of androgenetic alopecia: a cross-sectional study. [Journal Article]Aging Male. 2022 Dec; 25(1):242-248.AM
- Purpose: Androgenetic alopecia (AGA) is a common type of hair loss. Previous studies indicated that the relative length of the index and ring finger (2D:4D ratio) of AGA patients was lower than control. However, the correlation between 2D:4D ratio and disease severity is unclear. In this study, we sought to evaluate the relationship between digit ratio of the right hand and AGA severity in male p…
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- A comparative study of histopathologic features in alopecia areata and pattern hair loss. [Journal Article]J Cutan Pathol. 2023 Jan 06 [Online ahead of print]JC
- CONCLUSIONS: Common features of AA other than peribulbar infiltrates include a catagen/telogen shift, melanin in fibrous tracts, and small dystrophic follicles. Practitioners should consider these features when distinguishing AA from PHL in specimens without peribulbar infiltrates. The retrospective design limits our ability to exclude multifactorial alopecia, such as telogen effluvium.
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- A practical approach to the management of hair loss in patients with polycystic ovary syndrome. [Review]J Eur Acad Dermatol Venereol. 2023 Jan 06 [Online ahead of print]JE
- Female patterned hair loss (FPHL) is a common form of androgenetic alopecia in women and is characterized by a hormonally directed diffuse hair loss on the scalp. Management of FPHL is well described in the literature; however, treatment of FPHL in patients with co-morbid polycystic ovarian syndrome (PCOS), an endocrinologic condition found in reproductive-aged women, has not yet been reviewed. D…
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- Alopecia areata and pattern hair loss (androgenetic alopecia) on social media - Current public interest trends and cross-sectional analysis of YouTube and TikTok contents. [Journal Article]J Cosmet Dermatol. 2023 Jan 06 [Online ahead of print]JC
- CONCLUSIONS: AA-related contents on TikTok discussing personal experiences of female subjects were significantly more engaging. DISCERN and DAS scoring showed significantly higher quality and accuracy in videos created by healthcare providers on YouTube, but not TikTok, which could in part be related to YouTube videos being longer. RSV fluctuations corresponding to news in popular culture had high impact. Sponsorship disclosures were generally not reported in product promotional videos.
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- Randomized control trial to study the efficacy and safety of platelet-rich plasma as intraoperative holding solution in hair restoration surgery: A pilot study. [Journal Article]Med J Armed Forces India. 2023 Jan; 79(1):46-53.MJ
- CONCLUSIONS: Intraoperative PRP as a holding solution improves outcome in hair restoration surgery by a significant improvement in the mean density of the implanted follicular unit grafts at 6 months.
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- The Association of Serum Ferritin Levels With Non-scarring Alopecia in Women. [Journal Article]
- Objective We designed this study to evaluate the association of serum ferritin levels with non-scarring alopecia in women. Methodology All patients were diagnosed by performing a clinical examination of the crown part width and occiput. Ludwig's classification was used to categorize the cases into grades I-III. Different laboratory tests were performed for the baseline investigation, including se…
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- Quality of Life and Its Association with Androgenetic Alopecia Patients in Shanghai: A Cross-Sectional Study. [Journal Article]
- CONCLUSIONS: Androgenetic alopecia is associated with significantly reduced HRQoL in young, less educated, and single patients. Dermatologists should inquire about Quality of Life and appropriately support androgenetic alopecia patients.
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- Comparative analysis of scalp and gut microbiome in androgenetic alopecia: A Korean cross-sectional study. [Journal Article]
- Androgenetic alopecia (AGA) is a non-scarring and progressive form of hair loss occurring in both men and women. Although genetic predisposition and sex steroid hormones are the main causes, many factors remain unknown, and various extrinsic factors can negatively affect the lifespan of hair. We investigated skin-gut axis microorganisms as potential exogenous factors causing AGA, through comparat…
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- Comparison between topical cetirizine with minoxidil versus topical placebo with minoxidil in female androgenetic alopecia: a randomized, double-blind, placebo-controlled study. [Journal Article]Arch Dermatol Res. 2022 Dec 26 [Online ahead of print]AD
- Androgenetic alopecia (AGA) is the most common cause of hair loss in both genders with a higher psychological impact on females. Currently, topical minoxidil is the only FDA-approved treatment for female AGA and it needs life-long application and causes side effects. Cetirizine is an antihistamine that may be effective in hair loss treatment. This study aimed to compare the efficacy and safety of…
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- Guava (Psidium guajava L.) Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities. [Journal Article]
- Leaves of guava (Psidium guajava L.) have been used in Thai folk medicine without any supporting evidence as a traditional herbal remedy for hair loss. Androgenetic alopecia (AGA) is chronic hair loss caused by effects of androgens in those with a genetic predisposition, resulting in hair follicle miniaturization. Our objectives were to provide the mechanistic assessment of guava leaf extract on …
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- Erosive Pustular Dermatosis: Delving into Etiopathogenesis and Management. [Review]
- Erosive pustular dermatosis (EPD) is a chronic inflammatory skin disorder that usually affects mature individuals. It predominantly affects the scalp and can lead to scarring alopecia. Risk factors include actinic damage and androgenetic alopecia. A traumatic insult to the skin is considered a vital trigger of the condition. EPD is a diagnosis of exclusion; thus, several neoplastic, infectious, v…
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- Autologous Platelet-Rich Plasma (PRP) for Treating Androgenetic Alopecia: A Novel Treatment Protocol Standardized on 2 Cases. [Case Reports]
- Platelet-rich plasma (PRP) treatment has emerged in recent years as a valuable, effective, and affordable treatment for androgenetic alopecia. Androgenetic alopecia is the most common type of alopecia, affecting both men and women, and is characterized by diminished hair follicles mainly pronounced in the frontal region and vertex. A considerable variety of PRP treatment regimens have been descri…
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- Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases. [Review]
- The endocannabinoid system has been shown to be involved in various skin functions, such as melanogenesis and the maintenance of redox balance in skin cells exposed to UV radiation, as well as barrier functions, sebaceous gland activity, wound healing and the skin's immune response. In addition to the potential use of cannabinoids in the treatment and prevention of skin cancer, cannabinoid compou…
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- Study on hair root lipids of female androgenetic alopecia based on UPLC-Q-TOF/MS results. [Letter]J Eur Acad Dermatol Venereol. 2022 Dec 22 [Online ahead of print]JE
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- Investigation of hub genes and immune infiltration in androgenetic alopecia using bioinformatics analysis. [Journal Article]
- CONCLUSIONS: We discovered that the hub genes identified are closely linked with the causative factors of AGA, which could be used as the viable diagnostic and therapeutic target in the clinical applications.
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- SYMPTOMATOLOGY AND TREATMENT OF COVID-19 AFFECTING SKIN APPENDAGES: A NARRATIVE REVIEW BEYOND COVID-TOES. [Review]Georgian Med News. 2022 OctGM
- SARS-CoV-2 is the cause of COVID-19 disease and responsible for a pandemic since the 2020. Multiple organ involvement has been described including cutaneous symptoms. Affection of skin appendages, however, seems to be under-reported except for COVID-toes. We performed a PUBMED research for "COVID-19" OR "SARS-CoV-2" AND "skin appendages", "hair", "nails", and "skin glands" from January 2020 to Ap…
- PROTAC Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration. [Journal Article]Small Methods. 2023 Jan; 7(1):e2201293.SM
- Androgenetic alopecia (AGA) is a transracial and cross-gender disease worldwide with a youth-oriented tendency, but it lacks effective treatment. The binding of androgen receptor (AR) and androgen plays an essential role in the occurrence and progression of AGA. Herein, novel proteolysis targeting chimera degrader of AR (AR-PROTAC) is synthesized and integrated with dissolving microneedles (PROTA…
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- Automating Hair Loss Labels for Universally Scoring Alopecia From Images: Rethinking Alopecia Scores. [Journal Article]JAMA Dermatol. 2022 Dec 14 [Online ahead of print]JD
- CONCLUSIONS: In this research study,it is shown that an algorithm quantitating percentage hair loss may be applied to all forms of alopecia. A generalizable automated assessment of hair loss would provide a way to standardize measurements of hair loss across a range of conditions.
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- An analysis of shapes and location of anterior hairline in Asian men. [Journal Article]Arch Dermatol Res. 2022 Dec 13 [Online ahead of print]AD
- An individual's first impression can be influenced by a number of esthetic factors, one of which is a natural hairline. The anterior hairline can be affected by various factors, such as race, age, forehead shape, and hair loss progression, similar to androgenetic alopecia. Information on the shape, hairline location on the forehead, and race are required to classify the anterior hairline. Accordi…
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- Possible relationship between poor skin disorders prognosis and serum zinc level: A narrative review. [Journal Article]Dermatol Reports. 2022 Nov 21; 14(4):9512.DR
- Zinc is a trace nutrient essential for the normal growth and development of human body. The main aim was to evaluate the significant association between measured zinc status in relation to different skin disorders and their severity. PubMed®, Google® Scholar™ and Cochrane© Reviews databases were searched for studies from January 2017 to June 2021, using the terms; zinc serum levels, zinc plasma l…
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- An overview of the genetic aspects of hair loss and its connection with nutrition. [Review]
- Hair loss is a widespread concern in dermatology clinics, affecting both men's and women's quality of life. Hair loss can have many different causes, which are critical to identify in order to provide appropriate treatment. Hair loss can happen due to many variables, such as genetic factors or predisposition, vitamin and mineral deficiencies, skin problems, hair growth disorders, poor diet, hormo…
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- Observation on the Efficacy of a Combined Treatment for Moderate and Severe Androgenetic Alopecia Incorporating Electric Microneedles. [Journal Article]
- CONCLUSIONS: The combined treatment of moderate to severe AGA using the electric microneedle technique has a clear effect and can effectively increase the hair density. With a simple operation and mild side effects, the technique has wide application prospects.
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