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146 results
  • TGFβ1 orchestrates renal fibrosis following Escherichia coli pyelonephritis. [Journal Article]
    Physiol Rep. 2020 03; 8(6):e14401.Hreha TN, Collins CA, … Hunstad DA
  • Renal scarring after pyelonephritis is linked to long-term health risks for hypertension and chronic kidney disease. Androgen exposure increases susceptibility to, and severity of, uropathogenic Escherichia coli (UPEC) pyelonephritis and resultant scarring in both male and female mice, while anti-androgen therapy is protective against severe urinary tract infection (UTI) in these models. This wor…
  • Effect of testosterone cypionate and stanozolol on the heart of young trained mice: A morphometric study. [Journal Article]
    Steroids. 2019 05; 145:19-22.Vieira TM, Rossi Junior WC, … Esteves A
  • Testosterone cypionate and Stanozolol are Anabolic-Androgenic Steroids (AAS) which are synthetic substances that possess functions similar to testosterone. The use of these substances has increased considerably among youngsters and sports practitioners aiming better performance of with aesthetic purposes. The major concern is the effects caused by the inappropriate use of the substances, such as …
  • Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis. [Journal Article]
    Gut Microbes. 2018; 9(5):400-421.Sherman SB, Sarsour N, … Hill JW
  • CONCLUSIONS: We found that prenatal exposure to excess androgen negatively impacted cardiovascular function by increasing systolic and diastolic blood pressure and decreasing heart rate. Prenatal androgen was also associated with gut microbial dysbiosis and altered abundance of bacteria involved in metabolite production of short chain fatty acids. These results suggest that early-life exposure to hyperandrogenemia in daughters of women with PCOS may lead to long-term alterations in gut microbiota and cardiometabolic function.
  • Daily subcutaneous testosterone for management of testosterone deficiency. [Journal Article]
    Front Biosci (Elite Ed). 2018 03 01; 10(2):334-343.Yazdani N, Matthews Branch S
  • Testosterone deficiency (TD) is a public health concern, a predictor of metabolic syndrome, and is associated with an increased all-cause and cardiovascular mortality. Testosterone deficiency in men is treated by a variety of methods including injectable testosterone compounds, patches, gels, pellets, and oral preparations. The use of testosterone alone has been linked to various adverse effects …
  • Sex steroid modulation of cortisol secretion in sheep. [Journal Article]
    Animal. 2014 Jun; 8(6):960-7.van Lier E, Carriquiry M, Meikle A
  • There is strong evidence that the gonads modulate the hypothalamic-pituitary-adrenal axis. To investigate these sex differences at the adrenal glands of sheep we compared the cortisol response to ACTH (experiment 1) and measured the relative expression of oestrogen receptor alpha (ERS1), androgen receptor (AR), melanocortin 2 receptor (MC2R) and steroid acute regulatory protein (STAR) mRNA in adr…
  • Treatment of hypogonadism in males. [Review]
    Pediatr Endocrinol Rev. 2014 Feb; 11 Suppl 2:230-9.Watson S, Fuqua JS, Lee PA
  • The treatment of adolescent males with hypogonadism using testosterone is dependent on the underlying diagnosis as well as the patient's and family's preferences. Those with testicular failure, always a pathologic condition, begin lifelong therapy, while short-term therapy is often begun for those who have a delayed puberty. There is a wide variety of testosterone formulations available, with dif…
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