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963 results
  • Reversal of cold intolerance by testosterone in orchiectomized mice after tibial nerve transection. [Journal Article]
    Behav Brain Res. 2022 Dec 24; 441:114269.Khalilzadeh E, Aliyoldashi M, … Caspani O
  • Cold intolerance is a debilitating effect of nerve injury, has a strong impact on the life of patients and no advisable treatment exists against it. Testosterone influences pain pathways and has analgesic effects. A recent study showed testosterone as being an agonist of TRPM8, the predominant ion channel that contributes to cold hypersensitivity after injury. We investigated the effect of testos…
  • StatPearls: Anabolic Steroid Toxicity [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)MiddlebrookIgorICentral Michigan UniversitySchoenerBenjaminBCentral Michigan University COMBOOK
  • Androgenic-anabolic steroids (AAS) are widely missed worldwide as performance-enhancing agents. The use of AAS started in competitive sports and spread to non-competitive athletes. The World Anti-Doping Agency banned AAS since the 1950s and has continued adding new methods and new variations of AAS. Currently, the CDC estimates that the majority of AAS users are adolescent males.[1] The hypothala…
  • Considerations when treating male pubertal delay pharmacologically. [Review]
    Expert Opin Pharmacother. 2022 Dec; 23(17):1903-1914.Rey RA
  • Delayed puberty , usually affects psychosocial well-being. Patients and their parents show concern about genital development and stature. The condition is transient in most of the patients; nonetheless, the opportunity should not be missed to diagnose an underlying illness.
  • Testosterone Replacement Therapy in Chronic Kidney Disease Patients. [Journal Article]
    Nutrients. 2022 Aug 22; 14(16)Skiba R, Rymarz A, … Niemczyk S
  • (Background) The aim of our study was to evaluate the efficacy and safety of testosterone replacement therapy (TRT) in men with chronic kidney disease and hypogonadism on conservative and hemodialysis treatment. (Methods) The studied population consisted of 38 men on hemodialysis (HD), 46 men with CKD stages II-IV (predialysis group, PreD) and 35 men without kidney disease who were similar in age…
  • Testosterone Enanthate: An In Vitro Study of the Effects Triggered in MG-63 Cells. [Journal Article]
    Biomolecules. 2022 08 21; 12(8)Ghezzi B, Parisi L, … Macaluso GM
  • The aim of this study was to investigate the effects of the androgenic hormone testosterone enanthate (TE) on human MG-63 cells. MG-63 were cultured for 24 h in the presence of TE at increasing concentrations to assess its lethal dose. Therefore, the suitable concentration for a prolonged use of TE in vitro was assessed by viability assay over 9 days. Finally, MG-63 were exposed to TE for 14 days…
  • GeneReviews®: PROP1-Related Combined Pituitary Hormone Deficiency [BOOK]
    GeneReviews®. University of Washington, Seattle: Seattle (WA)Adam MP, Mirzaa GM, … Amemiya ACarvalho LR, Nishi MY, … Mendonca BBBOOK
  • PROP1-related combined pituitary hormone deficiency (CPHD) is associated with deficiencies of: growth hormone (GH); thyroid-stimulating hormone (TSH); the two gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH); prolactin (PrL); and occasionally adrenocorticotropic hormone (ACTH). At birth, in contrast to individuals with congenital CPHD of other etiologies, neonates wi…
  • Hypogonadism in male infants and adolescents: new androgen formulations. [Review]
    Horm Res Paediatr. 2021 Dec 16 [Online ahead of print]Chioma L, Cappa M
  • Background Male hypogonadism may be associated with micropenis and cryptorchidism in newborn, absent or incomplete pubertal development when it occurs during childhood. During puberty, androgen replacement therapy plays a pivotal role in subjects with hypogonadism to induce sexual maturation, growth acceleration, anabolic effects on fat-free mass growth increasing muscle strength, directly and in…
  • Normotensive rats with PCOS exhibit the hypertensive pattern: focus on oxidative stress. [Journal Article]
    Reproduction. 2021 12 09; 163(1):11-21.Joksimovic Jovic J, Jovic N, … Jakovljevic V
  • Numerous evidence implies complex interrelations between polycystic ovary syndrome (PCOS) and hypertension (HT) in reproductive-age women. In this study, we aimed to investigate the potential strain differences in ovarian morphology, hemodynamic, and biochemical characteristics in an androgen-induced PCOS rat model. A total of 24 rats of 3 weeks old (12 Wistar Kyoto - WK and 12 spontaneously hype…
  • Effects of testosterone treatment on transgender males: A single-institution study. [Journal Article]
    SAGE Open Med. 2021; 9:20503121211051546.Korpaisarn S, Chiewchalermsri D, … Sriphrapradang C
  • CONCLUSIONS: Gender-affirming hormone therapy is an effective and safe short-term treatment in Thai transgender men. Apart from the standard recommendation, uric acid, plasma glucose, and creatinine level evaluation before and during masculinizing hormone therapy are rational practices. An intramuscular testosterone enanthate 250 mg every 4 weeks is an alternative masculinizing regimen with decent efficacy and safety profile.
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