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4,861 results
  • Transient asystole associated with vasovagal reflex in an oral surgery patient: A case report. [Case Reports]
    SAGE Open Med Case Rep. 2023; 11:2050313X221146019.Shimoda H, Yamauchi K, Takahashi T
  • The perioperative cardiac events may be brought about by a relative imbalance of autonomic activities due to excessive psychological and physical stress. The present case study focuses on the asystole that can occur as a serious cardiac adverse event associated with vasovagal reflex likely to be triggered by venipuncture for securing an intravenous line during dental care. In addition, we describ…
  • Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication. [Case Reports]
    Case Rep Nephrol Dial. 2022 Sep-Dec; 12(3):163-166.Mekeirele M, Verheyen S, … Balthazar T
  • Benzodiazepine ingestion is frequent in patients admitted to ICU for intoxications. Generally, a supportive approach by securing the airway, breathing, and circulation is sufficient. Flumazenil is a well-known antidote for benzodiazepines but does not influence its elimination. Following preclinical data, we applied for the first time in humans a hemadsorption filter in a patient with a bromazepa…
  • Bromovalerylurea modulates GABAA receptor-mediated inhibitory neurotransmission while inducing sleep. [Journal Article]
    Biochem Biophys Res Commun. 2023 Jan 01; 638:176-183.Takeda H, Yoshimura Y, … Tanaka J
  • Bromovalerylurea (BU), an acyl urea derivative, was originally developed as a hypnotic/sedative. We recently reported that BU at a dose of 50 mg/kg ameliorates sepsis, Parkinson's disease, and traumatic brain injury in Wistar rat models through its anti-inflammatory actions on microglia and macrophages. However, since BU was developed more than 100 years ago, its hypnotic mechanism and characteri…
  • Remimazolam: An Updated Review of a New Sedative and Anaesthetic. [Review]
    Drug Des Devel Ther. 2022; 16:3957-3974.Hu Q, Liu X, … Lei X
  • Remimazolam (CNS7056) is a novel benzodiazepine for intravenous sedation; it has an ultra-short duration of action and was recently approved for use in procedural sedation and general anaesthesia. It acts on γ-aminobutyric acid type A receptors and is rapidly converted into an inactive metabolite by tissue esterase enzymes. Remimazolam has been successfully used in endoscopic inspection or surger…
  • GABAergic regulation of cell proliferation within the adult mouse spinal cord. [Journal Article]
    Neuropharmacology. 2023 Feb 01; 223:109326.New LE, Yanagawa Y, … Deuchars SA
  • Manipulation of neural stem cell proliferation and differentiation in the postnatal CNS is receiving significant attention due to therapeutic potential. In the spinal cord, such manipulations may promote repair in conditions such as multiple sclerosis or spinal cord injury, but may also limit excessive cell proliferation contributing to tumours such as ependymomas. We show that when ambient γ-ami…
  • Novel ultrashort-acting benzodiazepine remimazolam lowers shivering threshold in rabbits. [Journal Article]
    Front Pharmacol. 2022; 13:1019114.Muroya K, Ueda K, … Matsukawa T
  • Shivering after surgery or during therapeutic hypothermia can lead to serious complications, such as myocardial infarction and respiratory failure. Although several anesthetics and opioids are shown to have anti-shivering effects, their sedative and respiratory side effects dampen the usefulness of these drugs for the prevention of shivering. In the present study, we explored the potential of a n…
  • Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat. [Journal Article]
    Pharmaceuticals (Basel). 2022 Oct 12; 15(10)Lagard C, Vodovar D, … Mégarbane B
  • Tramadol overdose is frequently associated with the onset of seizures, usually considered as serotonin syndrome manifestations. Recently, the serotoninergic mechanism of tramadol-attributed seizures has been questioned. This study's aim was to identify the mechanisms involved in tramadol-induced seizures in overdose in rats. The investigations included (1) the effects of specific pretreatments on…
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