- Anesthesia for patients withPTRFmutations: a case report. [Journal Article]
- JCJA Clin Rep 2018; 4(1):11
- CONCLUSIONS: Patients withPTRFmutations require careful anesthetic planning. We planned to administer lipid-free, non-inhalational agents for the induction and maintenance of anesthesia. The anesthetic method used for this minor surgery was safe and effective.
- Sacred Maya incense, copal (Protium copal - Burseraceae), has antianxiety effects in animal models. [Journal Article]
- JEJ Ethnopharmacol 2018 Jan 29; 216:63-70
- CONCLUSIONS: This is the first study to show that copal incense from Protium copal elicits anxiolytic-like effects in fear and social interaction models as evidenced by a reduced learned fear behavior and an increase in active social interaction. It's high α and β-amyrin content suggests behavioral effects may be mediated, in part, by the known action of these terpenes at the benzodiazepine receptor. Furthermore, P. copal's observed activity through the eCB system via MAGL offers a new potential mechanism underlying the anxiolytic activity.
- Automated radiosynthesis and purification of [18F]flumazenil with solid phase extraction. [Journal Article]
- ARAppl Radiat Isot 2018 Jan 25; 135:110-114
- This paper describes the novel approach for preparation of [18F]flumazenil ([18F]FMZ), well known radioligand for assessment of GABAAreceptors by PET. The optimized reaction conditions allowed us to ...
This paper describes the novel approach for preparation of [18F]flumazenil ([18F]FMZ), well known radioligand for assessment of GABAAreceptors by PET. The optimized reaction conditions allowed us to implement commercially available SPE cartridges for [18F]FMZ purification avoiding HPLC. All procedures were performed with TRACERlab FX N Pro synthesizer in 53 min. Developed approach provided [18F]FMZ with high RCP (> 97%) and low level of chemical impurities (< 5 µg/mL). FMZ was routinely synthesized in 6.4 ± 0.7% RCY at EOS (not decay corrected, n = 8) and the molar radioactivity was > 185 GBq/μmol.
- Negative allosteric modulation of alpha 5-containing GABAAreceptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice. [Journal Article]
- PPsychopharmacology (Berl) 2018 Jan 26
- CONCLUSIONS: α5βγ2 GABAAreceptor NAMs might function as a pharmacological treatment for mood, amotivational syndromes, and psychomotor agitation in patients with Alzheimer's and other neurodegenerative disorders.
- Hibiscus rosa sinensis mediate anxiolytic effect via modulation of ionotropic GABA-A receptors: possible mechanism of action. [Journal Article]
- MBMetab Brain Dis 2018 Jan 25
- The current study was designed with the aim to investigate anti-anxiety potential of Hibiscus rosa sinensis roots and its possible mechanism of action. For this purpose hole board test, elevated plus...
The current study was designed with the aim to investigate anti-anxiety potential of Hibiscus rosa sinensis roots and its possible mechanism of action. For this purpose hole board test, elevated plus maze test and light/dark exploration test were employed. The ethanol extract of plant was administered orally at two different doses i.e. 100 and 500 mg/kg for consecutive 14 days. The results of present investigation indicate that plant extract significantly (p < 0.05) increased the number of head dips and rearings as compared to control on respective days of observation. The extract increased the time of permanence in open arms and the number of head dips in elevated plus maze. In light/dark test, our study indicate that Hibiscus rosa sinensis significantly (p < 0.05) increased the time spent in light compartment and number of entries as compared to control. In addition the anxiolytic effects of HRS at highest tested dose were blocked by flumazenil, a GABA-A receptor antagonist that indicate that Hibiscus rosa sinensis potentiated the GABAergic actions. The results propose that the ethanol extract of Hibiscus rosa sinensis has prospective anxiolytic effect in mice via inhibition of ionotropic GABA receptors, using different behavioral paradigms.
- Efficacy and safety of flumazenil injection for the reversal of midazolam sedation after elective outpatient endoscopy. [Journal Article]
- JDJ Dig Dis 2018 Jan 23
- CONCLUSIONS: The time of recovery-room stay after flumazenil administration was significantly shortened, and the use of the drug did not increase the risk of adverse events or uncomfortable symptoms. The use of flumazenil for reversing midazolam sedation seems to be safe and effective.
- Increase in extraction of I-123 iomazenil in patients with chronic cerebral ischemia. [Journal Article]
- PlosPLoS One 2018; 13(1):e0190720
- CONCLUSIONS: Our results suggested that the transportation efficiency of I-123 IMZ into the brain tissue was an indicator for evaluating severity of cerebral ischemia in patients with chronic steno-occlusive disease of ICA or MCA. Cerebral metabolic state can possibly be estimated by I-123 IMZ SPECT without cyclotron.
- Correction to: Parametric Imaging of [11C]Flumazenil Binding in the Rat Brain. [Published Erratum]
- MIMol Imaging Biol 2018 Jan 02
- The name of the second author was incorrectly cited and is corrected now, as displayed here.
The name of the second author was incorrectly cited and is corrected now, as displayed here.
- Is flumazenil an alternative for the treatment of hepatic encephalopathy? [Journal Article]
- MMedwave 2017 Dec 26; 17(9):e7113
- CONCLUSIONS: We identified two systematic reviews including fourteen randomized trials. We concluded flumazenil does not reduce mortality in patients with hepatic encephalopathy and it is not clear whether it leads to any clinical improvement because the certainty of the evidence is very low.
New Search Next
- Neurobiological mechanisms of antiallodynic effect of transcranial direct current stimulation (tDCS) in a mice model of neuropathic pain. [Journal Article]
- BRBrain Res 2018 03 01; 1682:14-23
- CONCLUSIONS: The antiallodynic effect of tDCS was associated with different neurotransmitters systems; the duration of these after-effects depended on the time exposure to tDCS.