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Unbound Medicine.
(Angioedema & anaphylaxis)
1,150 results
  • A clinical pathway for the diagnosis of sesame allergy in children. [Journal Article]
    World Allergy Organ J. 2022 Nov; 15(11):100713.Machnes-Maayan D, Yahia SH, … Agmon-Levin N
  • CONCLUSIONS: OFCs remain the gold standard for the diagnosis of Sesame Allergy and are indicated to define ST/SA status even in highly atopic patients with previous immediate allergic reactions to sesame. A decision-tree analysis based on clinical parameters easily available in every allergy clinic, can predict the outcome of sesame OFC in the vast majority of children, increasing the safety and availability of such diagnostic procedures.
  • A new classification option for NSAID hypersensitivity: Kalyoncu classification. [Journal Article]
    Allergol Immunopathol (Madr). 2022; 50(6):122-127.Özdemir E, Damadoğlu E, … Kalyoncu AF
  • CONCLUSIONS: Our research revealed that the Kalyoncu classification is more descriptive of patients with NERD exhibiting urticaria/angioedema-type reactions. It also provides future risk assessment for development of NERD. For controversial cases, the Kalyoncu classification can be utilized as a new complimentary option alone or in conjunction with ENDA classification.
  • Disease activity of patients with chronic urticaria receiving COVID-19 vaccines. [Journal Article]
    Asian Pac J Allergy Immunol. 2022 Oct 18 [Online ahead of print]Tuchinda P, Kulthanan K, … Rujitharanawong C
  • CONCLUSIONS: Approximately 15% of chronic urticaria patients reported exacerbation after receiving a COVID-19 vaccination. No serious events were observed. Chronic urticaria patients should be vaccinated against COVID-19 after a discussion of the risk of disease flare-up.
  • Diagnostic management of patients reporting symptoms after wheat ingestion. [Review]
    Front Nutr. 2022; 9:1007007.Costantino A, Aversano GM, … Elli L
  • Many patients report symptoms after wheat ingestion experiencing a wide spectrum of clinical manifestations. Three possible diagnoses have been recognized: celiac disease (CD), wheat allergy (WA), and non-celiac (gluten) wheat sensitivity (NCGS/NCWS). CD is a chronic immune-mediated disease of the small bowel caused by exposure to dietary gluten in genetically predisposed individuals, with a prev…
  • Treatment of hereditary angioedema-single or multiple pathways to the rescue. [Review]
    Front Allergy. 2022; 3:952233.Valerieva A, Longhurst HJ
  • Hereditary angioedema (HAE) is a rare disease caused by mutations in the SERPING1 gene. This results in deficient or dysfunctional C1 esterase inhibitor (C1-INH) and affects multiple proteases involved in the complement, contact-system, coagulation, and fibrinolytic pathways. Current options for the treatment and prevention of HAE attacks include treating all affected pathways via direct C1-INH r…
  • [Angioedema and anaphylaxis, a family story]. [Journal Article]
    Rev Infirm. 2022 Jun-Jul; 71(282):27-29.Martinet C, Gherri N, … Lefort H
  • Non-allergic angioedema has a worrying morbidity. Clinical examination is central, as C1-esterase inhibitor deficiency will not be documented in the acute phase. In the case of anaphylaxis that does not respond to adrenaline, an early diagnosis can optimise referral of the patient to a reference healthcare establishment for a specific therapeutic protocol (icatibant, C1 inhibitor) recently update…
  • Acute Urticaria and Anaphylaxis: Differences and Similarities in Clinical Management. [Review]
    Front Allergy. 2022; 3:840999.Ensina LF, Min TK, … Costa C
  • Acute urticaria is a common condition that presents with wheals and/or angioedema. However, these symptoms are also frequent in anaphylaxis, a life-threatening reaction that should be immediately diagnosed and treated. In both, mast cells play a central role in the physiopathology. Causes and triggers of acute urticaria and anaphylaxis are similar in general, but some peculiarities can be observe…
  • Intubating Special Populations. [Review]
    Emerg Med Clin North Am. 2022 Aug; 40(3):443-458.Somwaru B, Grossman D
  • Emergency clinicians are tasked with managing a variety of patients with acute deformities. One of the most acute situations management of the patient who presents with an airway emergency. Patients present with various pathologies may result in anatomically challenging intubation scenarios. Deferral of intubation is often not an option in the emergency department. In some cases, challenging anat…
  • StatPearls: Angioedema [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)MemonRuba J.RJSaint Joseph Mercy OaklandTiwariVivekanandVTemple UniversityBOOK
  • Angioedema is defined as " subcutaneous tissues and/or submucosal tissues circumscribed non-pitting edema affecting lips, face, neck, and extremities oral cavity, larynx, and gut." It becomes life-threatening when it involves the larynx, while intestinal angioedema is painful and mimics acute abdomen.[1][2] Angioedema was first described in 1882 by Quincke, then by Osler in 1888 (hereditary angio…
  • First allergy conference in Qatar: Let's explore allergy with a new lens. [Journal Article]
    Qatar Med J. 2022; 2022(2):1.Al-Nesf M, Ibrahim T
  • Allergic diseases are common medical conditions that now show an increasing trend globally and contributes to poor quality of life of the affected individual. Allergies can be fatal in a few instances such as anaphylaxis, severe asthma, and hereditary angioedema if the symptoms are not recognized and treated correctly. (1, 2) The first Allergy Conference in Qatar aimed to highlight the burden of …
  • Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS). [Review]
    J Asthma Allergy. 2022; 15:957-970.Vaz-Rodrigues R, Mazuecos L, de la Fuente J
  • The α-Gal syndrome (AGS) is a pathognomonic immunoglobulin E (IgE)-mediated delayed anaphylaxis in foods containing the oligosaccharide galactose-α-1,3-galactose (α-Gal) such as mammalian meat or dairy products. Clinical presentation of AGS can also comprise immediate hypersensitivity due to anticancer therapy, gelatin-containing vaccines or mammalian serum-based antivenom. The IgE initial sensit…
  • Use of clindamycin as an alternative antibiotic prophylaxis. [Journal Article]
    Perioper Care Oper Room Manag. 2022 Sep; 28Maisat W, Bermudez M, Yuki K
  • CONCLUSIONS: Clindamycin was largely administered in patients with non-severe HSRs, low-risk history or unknown reactions to PCN or cephalosporin, whom cefazolin could have been administered safely. Obtaining a detailed history of antibiotic allergy, allergy testing and/or direct oral challenge can de-label unsubstantiated PCN or cephalosporin allergy and ultimately reduce the incidence of SSIs by optimizing the rate of more effective antibiotic administration.
  • StatPearls: Type I Hypersensitivity Reaction [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)AbbasMalakMBeaumont HealthMoussaMohamedMBeaumont HealthAkelHassanHBeaumont HealthBOOK
  • The immune system plays a crucial role in maintaining health and protecting the human body against microbial invasions. However, this same system can lead to exaggerated immune and inflammatory responses that result in adverse outcomes known as hypersensitivity reactions. There are four traditional classifications for hypersensitivity reactions, and these include Type I, Type II, Type III, and Ty…
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