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(Angiotensin II receptor blockers)
37,479 results
  • Current threat of nitrosamines in pharmaceuticals and scientific strategies for risk mitigation. [Review]
    J Pharm Sci. 2023 Feb 03 [Online ahead of print]Tuesuwan B, Vongsutilers V
  • The current global situation of nitrosamine contamination has expanded from angiotensin-II receptor blockers (ARBs) to wide range of medicines as the risk of contamination via the drug substances, formulation, manufacturing process, and packaging is possible for many drug products. The understanding of chemistry, toxicology, and root causes of nitrosamines are mandatory to effectively evaluate an…
  • Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. [Journal Article]
    Proc Natl Acad Sci U S A. 2023 Feb 07; 120(6):e2219199120.Datta M, Chatterjee S, … Jain RK
  • Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma trials. Here, we found that ICBs induce cerebral edema in some patients and mice with glioblastoma. Through single-cell RNA sequencing, intravital imaging, and CD8+ T cell blocking studies in mice, we demonstrated that this edema results from an inflammatory response following antiprogrammed death 1 (PD1) antibody treatme…
  • [Retarding progression of chronic kidney disease]. [Review]
    Inn Med (Heidelb). 2023 Feb 01 [Online ahead of print]Saritas T, Floege J
  • Chronic kidney disease (CKD) affects about 10-15% of the German population with a steady increase. It is assumed that CKD will become the 5th most common cause of death worldwide in 2040. CKD is associated with high risk of mortality, morbidity, related in particular to cardiovascular disease, as well as high healthcare costs. Clinical strategies to manage CKD should encompass extensive life-styl…
  • Cardiorenal benefits of finerenone: protecting kidney and heart. [Review]
    Ann Med. 2023 Dec; 55(1):502-513.González-Juanatey JR, Górriz JL, … Facila L
  • Persons with diabetes and chronic kidney disease (CKD) have a high residual risk of developing cardiovascular (CV) complications despite treatment with renin-angiotensin system blockers and sodium-glucose cotransporter type 2 inhibitors. Overactivation of mineralocorticoid receptors plays a key role in the progression of renal and CV disease, mainly by promoting inflammation and fibrosis. Fineren…
  • [European guidelines on heart failure: pharmacotherapy]. [Review]
    Herz. 2023 Jan 25 [Online ahead of print]Grundmann S, von Zur Mühlen C
  • The new 2021 guidelines of the European Society of Cardiology (ESC) have broken with the old step by step treatment of heart failure and have fundamentally revised the strategy in the pharmacotherapy setting. For patients with heart failure and reduced ejection fraction ≤ 40%, the 4 substance groups angiotensin-converting enzyme (ACE) inhibitors/angiotensin receptor-neprilysin inhibitors (ARNI), …
  • Management of heart failure in patients with kidney disease - updates from the 2021 ESC guidelines. [Journal Article]
    Nephrol Dial Transplant. 2023 Jan 23 [Online ahead of print]Edwards NC, Price AM, … Birmingham Cardio-Renal Group
  • The wide overlap between the syndromes of chronic kidney disease and chronic heart failure means that familiarity with the 2021 European Society of Cardiology guidelines is of importance to nephrologists. The common risk factors for the two syndromes together with the adverse cardiac structural remodelling associated with chronic kidney disease means that many kidney disease patients are breathle…
  • [Mineralocorticoid receptor (MR)-associated mechanisms in diabetic kidney disease and clinical significance of MR antagonists]. [Review]
    Am J Nephrol. 2023 Jan 20 [Online ahead of print]Mende CW, Samarakoon R, Higgins PJ
  • CONCLUSIONS: Upregulation of the renin-angiotensin-aldosterone system is an important contributor to kidney disease progression, as highlighted by the results of trials evaluating angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with albuminuria. Increasing evidence suggests the existence of a multidirectional network that involves aldosterone, the mineralocorticoid receptor (MR), and the Ras-related C3 botulinum toxin substrate 1 (Rac1) as driving forces in the generation of reactive oxygen species and oxidative stress-induced injury in the initiation of interstitial nephritis and eventual fibrosis in chronic kidney disease and DKD. The MR is a key element of this triangle, as highlighted by the beneficial effect of MR antagonists in preventing or reducing aldosterone- or Rac1-related effects in basic science studies, and the improved patient outcomes observed in clinical studies.Aldosterone can promote kidney disease in diabetes via the MR and via MR-independent actions through Rac1. However, the MR remains a key element of this triangle, with clinical data supporting the use of MR antagonists in delaying the progression of kidney disease in diabetes.
  • Management of Heart Failure with Reduced Ejection Fraction. [Review]
    Curr Probl Cardiol. 2023 Jan 18 [Online ahead of print]Rashid AM, Khan MS, … Butler J
  • Heart failure with reduced ejection fraction (HFrEF) is a complex and progressive clinical condition characterized by dyspnea and functional impairment. HFrEF has a high burden of mortality and readmission rate making it one of the most significant public health challenges. Basic treatment strategies include diuretics for symptom relief and use of quadruple therapy (Angiotensin receptor blocker/n…
  • The Neurohormonal Overactivity Syndrome in Heart Failure. [Journal Article]
    Life (Basel). 2023 Jan 16; 13(1)Xanthopoulos A, Skoularigis J, Triposkiadis F
  • Heart failure (HF) is categorized arbitrarily based on the left ventricular ejection fraction (LVEF) in HF with reduced (HFrEF; LVEF < 40%), mildly reduced (HFmrEF; LVEF 40-49%), or preserved ejection fraction (HFpEF; LVEF ≥ 50%). In this opinion paper, based on (patho)physiological considerations, we contend that the neurohormonal overactivity syndrome (NOHS), which is present in all symptomatic…
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