- Patterns of within-host spread of Chlamydia trachomatis between vagina, endocervix and rectum revealed by comparative genomic analysis. [Preprint]bioRxiv. 2023 Jan 26B
- Chlamydia trachomatis , a gram-negative obligate intracellular bacterium, commonly causes sexually transmitted infections (STIs). Little is known about C. trachomatis transmission within the host, which is important for understanding disease epidemiology and progression. We used RNA-bait enrichment and whole-genome sequencing to compare rectal, vaginal and endocervical samples collected at the sa…
- PMC Free PDF
- HIV prevalence and associated risk factors among young tertiary student men who have sex with men (MSM) in Nairobi, Kenya: a respondent-driven sampling survey. [Journal Article]AIDS Res Ther. 2023 Feb 06; 20(1):7.AR
- CONCLUSIONS: HIV prevalence among TSMSM in Nairobi is alarmingly high, demonstrating a need for tailored prevention and control interventions for this young key population.
- Publisher Full Text (DOI)
- Radical Resection Combined with Intestinal Autotransplantation for Locally Advanced Pancreatic Cancer after Neoadjuvant Therapy: A Report of 36 Consecutive Cases. [Journal Article]Ann Surg. 2023 Jan 24 [Online ahead of print]AnnS
- CONCLUSIONS: Our attempt suggests safety of this modality and may be clinically beneficial for highly-selected patients with PDAC. However, experience of multidisciplinary pancreatic cancer care and intestinal transplantation is warranted.
- Publisher Full Text (DOI)
- Extranodal Involvement of the Anorectal Region in an HIV-Positive Patient With Plasmablastic Lymphoma: A Case Report. [Case Reports]
- Plasmablastic lymphoma (PbL) is a rare type of aggressive B-cell malignancy that has an extremely poor prognosis without chemotherapeutic treatment, requiring a high degree of suspicion for an early and accurate diagnosis. It has been classically described in patients infected with the human immunodeficiency virus (HIV). However, it accounts for only 2.6% of acquired immunodeficiency syndrome (AI…
- PMC Free PDF
- A modification of the anoplasty technique during a posterior sagittal anorectoplasty and anorectal vaginal urethroplasty closure: The para-U-stitch to prevent wound dehiscence. [Journal Article]Eur J Pediatr Surg. 2023 Jan 24 [Online ahead of print]EJ
- Wound dehiscence after posterior sagittal anorectoplasty (PSARP) or anorectal vaginal urethroplasty (PSARVUP) for anorectal malformation (ARM) is a morbid complication. We present a novel anoplasty technique employing para-U-stitches along the anterior and posterior portions of the anoplasty, which helps buttress the midline U-stitch and evert the rectal mucosa. We hypothesized that, in addition …
- Publisher Full Text (DOI)
- Prevalence of human papillomavirus genotypes and related cervical morphological results in southern Hunan Province of China, 2018-2020: Baseline measures at a tertiary institution prior to mass human papillomavirus vaccination. [Journal Article]
- CONCLUSIONS: This retrospective study demonstrated the prevalence and the distribution characteristics of HPV infection and its correlation with cervical lesions in southern Hunan Province. The comprehensive results of this survey can guide HPV vaccine research to protect against some common genotypes in China.
- PMC Free PDF
- Delayed vs. early enteral feeding after repair of congenital recto-vestibular fistula: The effect on perineal wound healing. [Journal Article]
- CONCLUSIONS: Delayed enteral feeding with PPN keeps the perineal wound less contaminated with stool. This promoted proper and fast healing with lower incidence of PWI. Also, PPN compensates the catabolic effects of both surgical trauma and fasting during the postoperative period and ensures maintenance of normal levels of essential nutrients that allow for proper healing.
- PMC Free PDF
- [Implantation metastasis of colorectal adenocarcinoma in an anal fistula]. [Case Reports]Orv Hetil. 2023 Jan 22; 164(3):110-113.OH
- In our case report, we describe a rare form of metastatic colorectal carcinoma, in which tumor cells spread intraluminally and metastasis occurs with implantation mechanism far from the primary tumor. A 43-year-old male patient developed perianal abscess. After surgical intervention a fistula-in-ano appeared at the site of the abscess. Fistulotomy was performed in another hospital. A few months l…
- Publisher Full Text (DOI)
- Crohn's Disease-Associated and Cryptoglandular Fistulas: Differences and Similarities. [Review]
- Perianal fistulas are defined as pathological connections between the anorectal canal and the perianal skin. Most perianal fistulas are cryptoglandular fistulas, which are thought to originate from infected anal glands. The remainder of the fistulas mainly arises as complications of Crohn's disease (CD), trauma, or as a result of malignancies. Fistulas in CD are considered as a consequence of a c…
- PMC Free PDF
- Screening and identification of hub gene and differential gene and mutation sequence analysis of related genes in colorectal cancer based on bioinformatics analysis. [Journal Article]
- CONCLUSIONS: The key genes closely related to colon cancer were effectively screened by the bioinformatics method, which provided a theoretical basis for further study of its mechanism.
- PMC Free PDF
- Trends of genital wart in Korea according to treatment method classification: Big data analysis of health care in 2010-2019. [Journal Article]
- CONCLUSIONS: Treatment for genital warts has increased rapidly over the past 10 years, and the increase in males is remarkable. The main treatment was surgery, and males mainly received surgical treatment, and females mainly received drug treatment. The primary medical institution was in charge of the most treatment. As the number of patients and related medical expenses are increasing rapidly, more attention and response to diseases are needed.
- PMC Free PDF
- Comprehensive Review of Anal Cytology. [Review]Acta Cytol. 2023 Jan 10 [Online ahead of print]AC
- CONCLUSIONS: Anal cytology is one modality that is a mainstay of many suggested screening guidelines. Interpretation and reporting follow current criteria for cervical/vaginal cytology per the Bethesda System, with site-specific alterations and changes in adequacy criteria to better accommodate some of the confounding factors encountered in anal cytology. While there are some limitations, such as a tendency to underestimate the degree of dysplasia and variable interobserver concordance rates, anal cytology, especially liquid-based preparations, overall performs well in detecting anal abnormalities and acts as an adequate screening tool. Importantly, most anal squamous dysplasias and cancers are also associated with human papillomavirus (HPV) infection, raising the possibility of HPV testing or genotyping as a component of screening and/or follow-up. Studies have also shown the efficacy of HPV vaccination in preventing anal lesions. Digital anorectal exam as well as anoscopy, particularly high-resolution anoscopy, are also often components of screening and follow-up. Management guidelines such as those put forth by the American Society for Colposcopy and Cervical Pathology (ASCCP) for cervical cancer are also not established for anal cancer. However, studies such as the Anal Cancer HSIL Outcomes Research (ANCHOR) trial have made significant strides in demonstrating successes in follow-up and treatment of anal lesions, findings that are crucial for establishing prevention and management guidelines going forward.
- Publisher Full Text (DOI)
- Efficacy and safety of traditional Chinese medicine retention enema in the treatment of anal sinusitis: A protocol for systematic review and meta-analysis. [Journal Article]
- CONCLUSIONS: This systematic review and meta-analysis will provide evidence for the efficacy and safety of TCM retention enema in the treatment of anal sinusitis.
- PMC Free PDF
- Perineal burn injury with hidradenitis suppurativa: A case report. [Case Reports]
- CONCLUSIONS: The pathogenesis of the HS in this case was the burn injury interfering with sweat gland formation around the anus. Moreover, the scar from the burn made surgical treatment difficult.
- PMC Free PDF
- Addressing the risk of monkeypox exposure during gastrointestinal endoscopy. [Review]
- The current monkeypox virus (MPV) outbreak is now a global health concern. MPV, a zoonotic double-stranded DNA virus, may be transmitted from human to human or by contaminated surfaces. Understanding the clinical characteristics and risks of MPV transmission are important, especially for health care workers, who may unknowingly encounter the virus while fulfilling their clinical responsibilities.…
- PMC Free PDF
- Efficacy and safety of traditional Chinese medicine external washing in the treatment of postoperative wound of diabetes complicated with anal fistula: Study protocol of a randomized, double-blind, placebo-controlled, multi-center clinical trial. [Journal Article]
- Introduction: Anal fistula is one of the commonest ailments seen by anorectal surgeons as surgery is currently the preferred treatment for it. Diabetes mellitus is a risk factor that can lead to slow wound healing after anal fistula surgery. Because of the large postoperative wound surface of anal fistula, patients with diabetes can have an increased probability of wound infection, which makes it…
- PMC Free PDF
- A novel nomogram based on nutritional and immune status predicting postoperative intra-abdominal infection in colorectal cancer. [Journal Article]Asia Pac J Clin Nutr. 2022; 31(4):626-635.AP
- CONCLUSIONS: In conclusion, we found that preoperative albumin, LWR <0.17, low subcutaneous fat mass, and low skeletal muscle mass were significantly correlated with intra-abdominal infection. Our nomogram was a simple and practical instrument to quantify the individual risk of intra-abdominal infection.
- Publisher Full Text (DOI)
- Efficacy of Injection of Freshly Collected Autologous Adipose Tissue into Complex Cryptoglandular Anal Fistulas. [Journal Article]Dis Colon Rectum. 2022 Oct 20 [Online ahead of print]DC
- CONCLUSIONS: Injection of freshly collected autologous adipose tissue is a safe treatment of complex cryptoglandular anal fistulas and may be an easily accessible inexpensive alternative to cultured autologous and allogenic adipose-tissue derived mesenchymal stem cells. See Video Abstract at http://links.lww.com/DCR/C45 .
- Publisher Full Text (DOI)
- Robotic-assisted repair of colovesical anastomosis after Hartmann's reversal procedure. [Video-Audio Media]Int Braz J Urol. 2022 12 14; 48IB
- CONCLUSIONS: Robotic-assisted repair represents an effective approach for the management of colovesical fistulae after Hartmann's reversal.
- Publisher Full Text (DOI)
- Natural Orifice Transanal Endoscopic Rectopexy for Complete Rectal Prolapse: Prospective Evolution of a New Technique and Short-term Outcomes. [Journal Article]
- CONCLUSIONS: This is a novel endoluminal technique for treating rectal prolapse obviating perirectal dissection, abdominal incisions, or a mesh. This can now be performed under complete endoscopic and fluoroscopic vision. It avoids general anesthesia and therefore can be an alternative for patients with comorbid conditions in whom the standard abdominal procedure may not be well tolerated. Larger randomized multicentric studies with longer follow-ups are warranted. See Video Abstract at http://links.lww.com/DCR/C59.
- Publisher Full Text (DOI)
- Myocarditis in monkeypox-infected patients: a case series. [Journal Article]
- CONCLUSIONS: These cases suggest an association between monkeypox infections and cardiac inflammatory complications. The development of chest pain in an infected patient should not be underestimated and should lead to prompt investigations for myocarditis. Monkeypox infection should also be included in the differential diagnosis of myocarditis, particularly in at-risk patients such as men who have sex with men with multiple partners in whom complete examination for skin or mucosal lesions should thus be performed.
- PMC Free PDF
- Abdominopelvic CT Imaging Findings in the Emergency Department in Patients With HIV Positive Status: Single Institute Experience. [Journal Article]Curr Probl Diagn Radiol. 2022 Nov 17 [Online ahead of print]CP
- CONCLUSIONS: The majority of ED visits within our population were attributed to infectious/inflammatory etiologies. CT findings demonstrated predominantly infectious/inflammatory processes, with anorectal pathology being the most common. Findings of malignancy on CT were less common, while opportunistic infections and AIDS-defining malignancies were uncommon.
- Publisher Full Text (DOI)
- Mycoplasma genitalium and Antimicrobial Resistance Among a Cohort of West African Men Who Have Sex With Men Using Preexposure Prophylaxis (CohMSM-PrEP ANRS 12369-Expertise France Study). [Journal Article]
- CONCLUSIONS: Although MG was highly prevalent in these MSM, macrolide resistance was almost nonexistent. Nevertheless, >10% of the samples were possibly resistant to fluoroquinolones. Heterogeneity in the prevalence of fluoroquinolone RAMs between countries may be explained by different antimicrobial consumption in humans and animals.
- PMC Free PDF
- Efficacy of oral fecal microbiota transplantation in recurrent bowel disease: A protocol for systematic review and meta-analysis. [Journal Article]
- CONCLUSIONS: This systematic review evaluated the efficacy and safety of oFMT in the treatment of RBD to provide more comprehensive evidence.
- PMC Free PDF
- Human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks: a global case series. [Case Reports]
- Between May and November, 2022, global outbreaks of human monkeypox virus infection have been reported in more than 78 000 people worldwide, predominantly in men who have sex with men. We describe the epidemiological and clinical characteristics of monkeypox virus infection in cisgender (cis) and transgender (trans) women and non-binary individuals assigned female sex at birth to improve identifi…
- PMC Free PDF
- Monkeypox. [Review]
- Monkeypox is a zoonotic illness caused by the monkeypox virus, an Orthopoxvirus in the same genus as the variola, vaccinia, and cowpox viruses. Since the detection of the first human case in the Democratic Republic of the Congo in 1970, the disease has caused sporadic infections and outbreaks, mainly restricted to some countries in west and central Africa. In July, 2022, WHO declared monkeypox a …
- PMC Free PDF
- Construction and assessment of a joint prediction model and nomogram for colorectal cancer. [Journal Article]
- CONCLUSIONS: Smoking, fecal occult blood, H. pylori infection, a history of appendectomy, serum CEA levels, and serum CA199 levels are independent risk factors for CRC, and the prediction model based on these factors had good predictive ability.
- PMC Free PDF
- Effect of the systemic immune-inflammation index on postoperative complications and the long-term prognosis of patients with colorectal cancer: a retrospective cohort study. [Journal Article]
- CONCLUSIONS: The SII index has certain predictive value for the diagnosis of postoperative infectious complications and the long-term prognosis of CRC patients.
- PMC Free PDF
- Optimisation of treatments for oral Neisseria gonorrhoeae infection: Pharmacokinetics Study (STI-PK project) - study protocol for non-randomised clinical trial. [Clinical Trial]
- Neisseria gonorrhoeae infections are common and incidence increasing. Oropharyngeal infections are associated with greater treatment failure compared with other sites and drive transmission to anogenital sites through saliva. Gonococcal resistance is increasing and new treatments are scarce, therefore, clinicians must optimise currently available and emerging treatments in order to have efficacio…
- PMC Free PDF
- A Novel Device for Intraoperative Hypothermia Prevention in Patients with Lower Abdominal Surgery: A Prospective Randomized Single-Center Study. [Journal Article]Ther Hypothermia Temp Manag. 2022 Nov 11 [Online ahead of print]TH
- This study aims to explore the value of lithotomy position thermal sleeve application during lower abdominal surgery in patients with hypothermia. A total of 100 patients who underwent urinary, gastrointestinal, or gynecological operations were included in this study. The patients were randomly divided into two groups: the test group (n = 50) and the control group (n = 50). In the control group, …
- Publisher Full Text (DOI)