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4,525 results
  • Deletion of Androgen Receptor in LepRb Cells Improves Estrous Cycles in Prenatally Androgenized Mice. [Journal Article]
    Endocrinology. 2023 Jan 23 [Online ahead of print]Cara AL, Burger LL, … Elias CF
  • Androgens are steroid hormones crucial for sexual differentiation of the brain and reproductive function. In excess, however, androgens may decrease fertility as observed in polycystic ovary syndrome, a common endocrine disorder characterized by oligo/anovulation and/or polycystic ovaries. Hyperandrogenism may also disrupt energy homeostasis, inducing higher central adiposity, insulin resistance,…
  • The role of circulating miRNAs in mechanism of action and prediction of therapeutic responses of metformin in polycystic ovarian syndrome. [Journal Article]
    Fertil Steril. 2023 Jan 07 [Online ahead of print]Huang CC, Yang PK, … Chen MJ
  • CONCLUSIONS: The present study demonstrated a distinct pattern of baseline expression and chronological changes in the levels of several circulatory miRNAs between the MET-OV and MET-AO groups, suggesting that aberrantly overexpressed diabetogenic miRNAs are involved in the pathophysiology of chronic anovulation in PCOS and their downregulation might contribute toward the therapeutic effects of metformin. This could provide new insights into the mechanism of action and applicability of individualized metformin therapy in women with PCOS.
  • Polycystic ovary syndrome and adipose tissue. [Review]
    Ann Endocrinol (Paris). 2023 Jan 07 [Online ahead of print]Lemaitre M, Christin-Maitre S, Kerlan V
  • Polycystic ovary syndrome (PCOS) is the most common endocrine metabolic disorder in women of reproductive age. Typically, it is associated with ovulatory dysfunction: dysovulation or anovulation, and symptoms of hyperandrogenism. It incurs risk of metabolic disorders such as diabetes, dyslipidemia and fatty liver. As a key endocrine organ in metabolic homeostasis, adipose tissue is often implicat…
  • [PCOS - desire for children and pregnancy]. [Journal Article]
    Dtsch Med Wochenschr. 2023 Jan; 148(1-02):34-39.Hancke K
  • Polycystic ovary syndrome (PCOS) is diagnosed according to the Rotterdam criteria, where two of the following three criteria must be met: Anovulation, hyperandrogenism, and characteristic morphology by sonography. Women diagnosed with PCOS are at higher risk for diabetes and impaired glucose tolerance. Therefore, these women should be carefully counselled about lifestyle measures and improvements…
  • Cardiovascular disease risk in offspring of polycystic ovary syndrome. [Review]
    Front Endocrinol (Lausanne). 2022; 13:977819.Shawky NM
  • Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women at reproductive age. PCOS diagnosis (Rotterdam criteria) is based on the presence of two out of three criteria; clinical and/or biochemical hyperandrogenism, oligo- or an-ovulation and polycystic ovaries. PCOS women suffer from a constellation of reproductive and metabolic abnormalities including obesity and in…
  • Dietary supplements for polycystic ovary syndrome. [Review]
    J Prev Med Hyg. 2022 Jun; 63(2 Suppl 3):E206-E213.Kiani AK, Donato K, … Bertelli M
  • Polycystic ovary syndrome (PCOS) is one of the most prevalent female endocrine reproductive disorders, affecting between 4 to 18% of the women in their reproductive age. It is generally characterized by several clinical aspects, among which anovulation, inflammation and infertility. Moreover, PCOS has several health implications, including increased metabolic, reproductive, and psychological risk…
  • Atypical Presentation of a Giant Hemorrhagic Ovarian Cyst. [Case Reports]
    J Obstet Gynaecol India. 2022 Dec; 72(Suppl 2):435-438.Sen S, Maurya R, … Srivastava H
  • Hemorrhagic ovarian cysts (HOCs) are frequently seen in reproductive age women, developing in the luteal phase of ovulatory cycles. Giant HOCs are rare, as bleeding inside a closed space causes acute pain leading to early diagnosis. Anovulation or oligoovulation is a defining feature of polycystic ovarian syndrome (PCOS), and hence, functional cysts are uncommon in PCOS patients. This report desc…
  • Evaluation of socio-demographic and clinical characteristics of PCOS patients attending a tertiary care institute in Colombo. [Journal Article]
    BMC Endocr Disord. 2022 Nov 21; 22(1):289.Ranathunga I, Athukorala TG, … Somasundaram NP
  • CONCLUSIONS: The majority of the population were overweight or obese and had higher prevalence of insulin resistance and non-alcoholic fatty liver. Out of the clinical characteristics used to make the diagnosis of PCOS, the presence of clinical or biochemical evidence of hyperandrogenism and irregular menstrual cycles are more common than the detection of polycystic ovaries on trans-vaginal USS. The higher prevalence of overweight, obesity, insulin resistance and NAFLD associated with PCOS makes the diagnosis and management of the disease crucial to prevent long term consequences of the disease.
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