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4,305 results
  • Disulfiram-like Reaction With Metronidazole: An Unsuspected Culprit. [Case Reports]
    J Pediatr Pharmacol Ther 2019 Sep-Oct; 24(5):445-449Alonzo MM, Lewis TV, Miller JL
  • The association of disulfiram-like reaction with concomitant use of metronidazole and alcohol has been reported in the literature; however, alcohol containing oral liquids may not always be identified as a culprit. A case of a 14-year-old patient who experienced a possible disulfiram-like interaction while receiving metronidazole and Prednisone Intensol solution is reported. Metronidazole oral su…
  • Substance use disorders among older adults: A review of randomized controlled pharmacotherapy trials. [Editorial]
    World J Psychiatry 2019; 9(5):78-82Tampi RR, Chhatlani A, … Lingamchetty T
  • Substance use disorders (SUDs) are a growing problem among older adults. Acamprosate, disulfiram, and naltrexone are United States Food and Drug Administration (referred to as FDA) approved for the treatment of alcohol use disorder, and buprenorphine is approved for the treatment of opiate use disorder among adults. However, the data on the use of these medications for the treatment of SUDs among…
  • ALDH1A3 Regulations of Matricellular Proteins Promote Vascular Smooth Muscle Cell Proliferation. [Journal Article]
    iScience 2019; 19:872-882Xie X, Urabe G, … Kent CK
  • Vascular smooth muscle cell (VSMC) proliferation promotes intimal hyperplasia (IH) in occluding vascular diseases. Here we identified a positive role of ALDH1A3 (an aldehyde dehydrogenase) in this pro-IH process. The expression of ALDH1A3, but not that of 18 other isoforms of the ALDH family, was substantially increased in cytokine-stimulated VSMCs. PDGF(BB) stimulated VSMC total ALDH activity an…
  • Disulfiram Overcomes Cisplatin Resistance in Human Embryonal Carcinoma Cells. [Journal Article]
    Cancers (Basel) 2019; 11(9)Schmidtova S, Kalavska K, … Kucerova L
  • Cisplatin resistance in testicular germ cell tumors (TGCTs) is a clinical challenge. We investigated the underlying mechanisms associated with cancer stem cell (CSC) markers and modalities circumventing the chemoresistance. Chemoresistant models (designated as CisR) of human embryonal carcinoma cell lines NTERA-2 and NCCIT were derived and characterized using flow cytometry, gene expression, func…
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