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Unbound Medicine.
(Antagon)
290 results
  • What is the optimal GnRH antagonist protocol for ovarian stimulation during ART treatment? A systematic review and network meta-analysis. [Journal Article]
    Hum Reprod Update. 2023 Jan 03 [Online ahead of print]Venetis CA, Storr A, … D'Hooghe T
  • CONCLUSIONS: Available evidence, mostly of low quality and certainty, suggests that different antagonist protocols should not be considered as equivalent for clinical decision-making. More trials are required to assess the comparative effectiveness of ganirelix versus cetrorelix, the effect of different pretreatment interventions (e.g. progestins or oestradiol) or the effect of different criteria for initiation of the antagonist in the flexible protocol. Furthermore, more studies are required examining the optimal GnRH antagonist protocol in women with high or low response to ovarian stimulation.
  • Impulsive time series modeling with application to luteinizing hormone data. [Journal Article]
    Front Endocrinol (Lausanne). 2022; 13:957993.Runvik H, Medvedev A
  • This work considers the estimation of impulsive time series pertaining to biomedical systems and, in particular, to endocrine ones. We assume a signal model in the form of the output of a continuous linear time-invariant system driven by a sequence of instantaneous impulses, which concept is utilized here, in particular, for modeling of the male reproductive hormone axis. An estimation method to …
  • ETB receptor-mediated vasodilation is regulated by estradiol in young women. [Clinical Trial]
    Am J Physiol Heart Circ Physiol. 2021 09 01; 321(3):H592-H598.Shoemaker LN, Haigh KM, … Wenner MM
  • The endothelin-B (ETB) receptor is a key regulator of vascular endothelial function in women. We have previously shown that the ETB receptor mediates vasodilation in young women, an effect that is lost after menopause. However, the direct impact of changes in estradiol (E2) on ETB receptor function in women remains unclear. Therefore, the purpose of this study was to test the hypothesis that E2 e…
  • The Effect of Luteinising Hormone Suppression in In Vitro Fertilisation Antagonist Cycles. [Journal Article]
    Reprod Sci. 2021 11; 28(11):3164-3170.Goh JP, Lee JCS, … Liu S
  • Use of GnRH antagonists in IVF stimulation protocols shortens controlled ovarian hyperstimulation (COH) and reduces the risk of ovarian hyperstimulation syndrome (OHSS). However, profound reduction in LH levels has been associated with use of GnRH antagonists. This study aims to determine if LH suppression during GnRH antagonist cycles results in poorer IVF outcomes. This was a prospective pilot …
  • Practical guidance for use of oral semaglutide in primary care: a narrative review. [Journal Article]
    Postgrad Med. 2020 Nov; 132(8):687-696.Morales J, Shubrook JH, Skolnik N
  • As the cornerstone of type 2 diabetes (T2D) management within the community, primary care providers are now faced with the challenge of not only managing diabetes itself, but also preventing hypoglycemia and weight gain associated with intensive disease management, and reducing cardiovascular risk. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are well established as efficacious treatments…
  • Suboptimal response to GnRH-agonist trigger during oocyte cryopreservation: a case series. [Case Reports]
    Reprod Biol Endocrinol. 2020 Jun 05; 18(1):59.Russo M, Liu K, Chan C
  • CONCLUSIONS: These findings highlight the potential risk of a suboptimal response to a GnRH-a trigger in patients undergoing LPS, controlled ovarian stimulation for oocyte cryopreservation. This risk might be attributed to the downregulation of GnRH receptors by elevated serum progesterone levels during the luteal phase. Currently, there is insufficient evidence to recommend for or against the use of a GnRH-a trigger during LPS controlled ovarian stimulation. This case series offers a number of management strategies to mitigate this risk and emphasizes the need for further research in this area.
  • Luteal estradiol pretreatment of poor and normal responders during GnRH antagonist protocol. [Journal Article]
    Gynecol Endocrinol. 2019 Dec; 35(12):1067-1071.Sefrioui O, Madkour A, … Louanjli N
  • Luteal estradiol pretreatment (LEP) to IVF protocols designed to improve follicle synchronization and retrieval of mature oocytes. We conducted a retrospective study including women undergoing IVF program who were given a course of 4 mg oral estradiol-17β daily from day 20 of the same cycle until day 1 of their next cycle before starting an antagonist protocol, forming LEP-group but control-group…
  • The effect of a GnRH antagonist on follicle maturation in normal women. [Clinical Trial]
    Reprod Biomed Online. 2019 Jul; 39(1):84-92.Pousias S, Messini CI, … Dafopoulos K
  • CONCLUSIONS: This study demonstrates for the first time that in normal women dominant follicle selection failed during treatment with ganirelix. As there was a similar gonadotrophin profile in the two cycles, it is suggested that ganirelix interferes with the process of follicle selection by acting in the ovary.
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