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(Antibiotic associated colitis)
8,769 results
  • Inflammatory Bowel Diseases Before and After 1990. [Journal Article]
    Gastro Hep Adv. 2023; 2(1):22-32.Truta B, Begum F, … Brant SR
  • CONCLUSIONS: Significantly increase in ex-smoking correlates with UC incidence post 1990. Conversely, smoking risk decreased significantly post 1990 despite rising CD incidence. CD-GRS likewise trended to decrease post 1990 only when not accounting for a significant decrease in CD surgery. We therefore deduce that unaccounted risk factors (eg, dietary, obesity, antibiotic use, improved hygiene, etc.) or greater detection or presence of mild CD may underlie post-1990 increased CD incidence.
  • Make It Less difficile: Understanding Genetic Evolution and Global Spread of Clostridioides difficile. [Review]
    Genes (Basel). 2022 11 24; 13(12)Mengoli M, Barone M, … Turroni S
  • Clostridioides difficile is an obligate anaerobic pathogen among the most common causes of healthcare-associated infections. It poses a global threat due to the clinical outcomes of infection and resistance to antibiotics recommended by international guidelines for its eradication. In particular, C. difficile infection can lead to fulminant colitis associated with shock, hypotension, megacolon, a…
  • The impact of dietary fibers on Clostridioides difficile infection in a mouse model. [Journal Article]
    Front Cell Infect Microbiol. 2022; 12:1028267.Wu Z, Xu Q, … Li L
  • Diets rich in fiber may provide health benefits and regulate the gut microbiome, which affects the immune system. However, the role of dietary fiber in Clostridioides difficile infection (CDI) is controversial. Here, we investigated the use of fermentable fibers, such as inulin or pectin, to replace the insoluble fiber cellulose to explore how dietary fiber affects C. difficile-induced colitis in…
  • Gut Microbiota and Clostridium difficile: What We Know and the New Frontiers. [Review]
    Int J Mol Sci. 2022 Nov 01; 23(21)Piccioni A, Rosa F, … Candelli M
  • Our digestive system, particularly our intestines, harbors a vast amount of microorganisms, whose genetic makeup is referred to as the microbiome. Clostridium difficile is a spore-forming Gram-positive bacterium, which can cause an infection whose symptoms range from asymptomatic colonization to fearsome complications such as the onset of toxic megacolon. The relationship between gut microbiota a…
  • [Ulcerative colitis complicated by pyoderma gangrenosum and multiple aseptic abscesses]. [Journal Article]
    Nihon Shokakibyo Gakkai Zasshi. 2022; 119(11):1014-1021.Kita A, Hashimoto Y, … Uraoka T
  • A woman in her 30s was diagnosed with ulcerative colitis (UC) 4 years ago and treated with tacrolimus, azathioprine, and prednisolone 5mg (PSL). Skin ulcers appeared on the right lower leg during the course of treatment, diagnosed as pyoderma gangrenosum (PG). The patient initially improved with an increased PSL and infliximab dose, but then developed multiple skin ulcers and folliculitis through…
  • Antibiotics in the pathogenesis of diabetes and inflammatory diseases of the gastrointestinal tract. [Review]
    Nat Rev Gastroenterol Hepatol. 2023 Feb; 20(2):81-100.Fenneman AC, Weidner M, … Blaser MJ
  • Antibiotic use is increasing worldwide. However, the use of antibiotics is clearly associated with changes in gut microbiome composition and function, and perturbations have been identified as potential environmental risk factors for chronic inflammatory disorders of the gastrointestinal tract. In this Review, we examine the association between the use of antibiotics and the onset and development…
  • Shorter is better: The case for short antibiotic courses for common infections in solid organ transplant recipients. [Review]
    Transpl Infect Dis. 2022 Oct; 24(5):e13896.Imlay H, Spellberg B
  • CONCLUSIONS: There are known harms associated with antibiotics and, when studied, existing data do not demonstrate harm associated with shorter courses of antibiotics among SOTRs. Furthermore, several RCTs did include some immune compromised patients and found shorter therapy to result in similar clinical efficacy with diminished adverse effects. Shorter antibiotic durations should be considered in SOTRs, and questions of antibiotic duration among SOTRs should be prioritized for study in clinical trials.
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