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(Anticholinergic poisoning)
3,403 results
  • Pleiotropic effects and pharmacological properties of penehyclidine hydrochloride. [Review]
  • DDDrug Des Devel Ther 2018; 12:3289-3299
  • Wang Y, Gao Y, Ma J
  • CONCLUSIONS: PHC has beneficial pharmacological properties used in the treatment of organophosphorus poisoning and as a preanesthetic medication for its few side effects. It also has protective effects on multiple organs, suggesting that PHC has extensive clinical application value which is worth further research. This review should be of help to those intending to research these topics further.
  • Efficacy of antidotes and their combinations in the treatment of acute carbamate poisoning in rats. [Journal Article]
  • TToxicology 2018 Sep 01; 408:113-124
  • Stojiljković MP, Škrbić R, … Vulović M
  • CONCLUSIONS: Mechanism of physostigmine-induced lethal effect is predominantly central and it involves inhibition of brain AChE, while pyridostigmine produces the same effect exclusively outside the central nervous system, by inhibiting AChE in the respiratory muscles. As a consequence, increasing doses of atropine and their combination with hexamethonium assure excellent protection against physostigmine toxicity, while the best protection against pyridostigmine is provided by a strictly peripherally acting antinicotinic d-tubocurarine and bispyridinium oxime HI-6. The oxime acts as antidote against physostigmine and pyridostigmine poisoning by reactivating AChE in the brain and diaphragm, respectively.
  • Cerbera odollam toxicity: A review. [Review]
  • JFJ Forensic Leg Med 2018; 58:113-116
  • Menezes RG, Usman MS, … Luis SA
  • Cerbera odollam is a plant species of the Apocynaceae family. It is often dubbed the 'suicide tree' due to its strong cardiotoxic effects, which make it a suitable means to attempt suicide. The plant...
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