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Unbound Medicine.
(Antidiuretic hormone ADH syndrome of inappropriate)
2,112 results
  • Triphasic response after endoscopic craniopharyngioma resection and its dependency on infundibular preservation or sacrifice. [Journal Article]
    J Neurosurg. 2023 Feb 03 [Online ahead of print]Lopez DC, Almeida JP, … Recinos PF
  • CONCLUSIONS: Following endonasal craniopharyngioma resection, the triphasic response occurs in nearly half of infundibular transection cases. DI begins earlier with infundibular transection. On the basis of the study findings in which no patients met the criteria for SIADH or were endocrinologically unstable after postoperative day 6, it is reasonable to suggest that otherwise stable patients can be discharged at or before postoperative day 6 when ADH fluctuations have normalized and endocrinopathy is appropriately managed with oral desmopressin. Infundibular transection status may impact postoperative hormonal replacement strategies, but additional studies should evaluate their efficacies.
  • Aquaporins in Edema. [Journal Article]
    Adv Exp Med Biol. 2023; 1398:281-287.Li N, Ying Y, Yang B
  • One of the most prevalent indications of water-electrolyte imbalance is edema. Aquaporins (AQPs) are a protein family that can function as water channels. Osmoregulation and body water homeostasis are dependent on the regulation of AQPs. Human kidneys contain nine AQPs, five of which have been demonstrated to have a role in body water balance: AQP1, AQP2, AQP3, AQP4, and AQP7. Water imbalance is …
  • Intractable hyponatremia complicated by a reset osmostat: a case report. [Case Reports]
    J Med Case Rep. 2023 Jan 14; 17(1):13.Kamel MH, Upadhyay A, Borkan SC
  • CONCLUSIONS: Preservation of urinary concentrating and diluting ability at a lower-than-normal serum sodium concentration, especially in the setting of chronic hyponatremia, is diagnostic of a reset osmostat. The presence of a reset osmostat often confounds the treatment of concomitant acute hyponatremia. Early recognition of a reset osmostat avoids the need to normalize serum sodium concentration, expedites hospital discharge, and limits potential harm from overcorrecting acute hyponatremia.
  • Endotext: Endocrine testing for the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) [BOOK]
    Endotext., Inc.: South Dartmouth (MA)Feingold KR, Anawalt B, … Wilson DPPliquett RU, Obermuller NBOOK
  • The diagnosis of Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) relies on an adequate assessment of a hyponatremic state (that is a serum sodium level <136 mmol/l) and on the exclusion of other causative conditions leading to an adequate secretion of antidiuretic hormone (ADH). The understanding of mechanisms involved in pathological ADH secretion is essential for diagnosis and …
  • Human herpesvirus 6 (HHV-6) associated permanent hyponatremia in umbilical cord blood transplant recipient. [Case Reports]
    Transpl Immunol. 2023 02; 76:101742.Gannamani V, Varma A, … Ustun C
  • Long-term neurocognitive deficits after human herpesvirus-6 (HHV-6) infection are common in stem-cell transplant recipients, but SIADH (Syndrome of inappropriate antidiuretic hormone secretion) with persistent hyponatremia is rare. A 51-year-old woman presented with somnolence, hyponatremia (121 mmol/L) and HHV-6 viremia (80,330 copies/ml) on day +22 post umbilical cord blood transplant (UCBT). W…
  • Disorders of Salt and Water Balance After Pituitary Surgery. [Journal Article]
    J Clin Endocrinol Metab. 2022 12 17; 108(1):198-208.Brooks EK, Inder WJ
  • Transsphenoidal surgery is the first-line treatment for many clinically significant pituitary tumors and sellar lesions. Although complication rates are low when performed at high-volume centers, disorders of salt and water balance are relatively common postoperatively. Both, or either, central diabetes insipidus (recently renamed arginine vasopressin deficiency - AVP-D), caused by a deficiency i…
  • A case of linezolid-induced SIADH in elderly and a review of the literature. [Case Reports]
    Eur Rev Med Pharmacol Sci. 2022 08; 26(16):5706-5709.Dong QW, Tang L, … Sun P
  • CONCLUSIONS: This is the fourth case of linezolid-induced SIADH. A thorough workup was essential for the diagnosis to correctly differentiate between SIADH and other causes of hyponatremia, which helped us properly conducting follow-up treatments. SIADH is a rare but serious side effect of linezolid, and practicing physicians should be aware of this complication. It is necessary to periodically monitor the serum sodium.
  • Symptomatic hyponatremia after ChAdOx1 nCoV-19 coronavirus disease-19 vaccination. [Case Reports]
    Clin Nephrol. 2022 Sep; 98(3):162-166.Chienwichai K, Sriinkua P, Chang A
  • Adverse events, particularly severe adverse events, after coronavirus disease vaccination are the primary concern for many patients. We present the first report of symptomatic hyponatremia, a potentially life-threatening condition, after administration of the ChAdOx1 nCoV-19 coronavirus disease-19 vaccine. A 24-year-old man developed altered consciousness and high-grade fever a day after receivin…
  • StatPearls: Neurohypophysis [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)Santos FontanezSantos E.SEUniversity of Puerto Rico-SOMDe JesusOrlandoOUniversity of Puerto Rico, Medical Sciences Campus, Neurosurgery SectionBOOK
  • The neurohypophysis (pars posterior) is a structure that is located at the base of the brain and is the posterior lobe of the pituitary gland. Its embryological origin is from the neuroectodermal layer called the infundibulum. The neurohypophysis is divided into two regions; the pars nervosa and the infundibular stalk. Sometimes the pars intermedia and the median eminence are included. It secrete…
  • Clinical efficacy of urea treatment in syndrome of inappropriate antidiuretic hormone secretion. [Journal Article]
    Sci Rep. 2022 06 17; 12(1):10266.Perelló-Camacho E, Pomares-Gómez FJ, … Domínguez-Escribano JR
  • The aim of this work is to examine our experience in the use of urea in patients with SIADH. Observational retrospective analysis of 48 patients with SIADH that have been treated with urea in a third-level hospital. Pre-post analysis of serum sodium levels. The 48 patients with SIADH had a median age of 78.5 (range 26-97 years). The serum sodium nadir was 119.8 ± 5.0 mmoL/L and at the beginning o…
  • Syndrome of inappropriate antidiuretic hormone secretion. [Review]
    Med Clin (Barc). 2022 08 12; 159(3):139-146.Poch E, Molina A, Piñeiro G
  • Hyponatremia is the most frequent electrolytic disorder in hospitalized patients, and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), the most frequent cause of hiponatremia with clinically normal extracellular volume. It consists of a disorder of the regulation of body water that obeys to different causes, mainly cancer, pulmonary illnesses, disorders of the central nerv…
  • Severe Hyponatremia During First Cycle of Cyclophosphamide/Doxorubicin Chemotherapy. [Journal Article]
    Am J Ther. 2022 May 18 [Online ahead of print]Jamhour C, Haddad A, Daw H
  • Syndrome of inappropriate anti-diuretic hormone release (SIDAH) is a condition characterized by an unregulated release of anti-diuretic hormone (ADH) resulting in increased water retention and decreased plasma osmolarity. Without regulation, ADH release will cause a significant decrease in plasma sodium concentration and can present with cramping, nausea, vomiting, and in severe cases, seizures, …
  • Clinical Implications, Evaluation, and Management of Hyponatremia in Cirrhosis. [Review]
    J Clin Exp Hepatol. 2022 Mar-Apr; 12(2):575-594.Praharaj DL, Anand AC
  • Hyponatremia is the most common electrolyte abnormality in patients with decompensated cirrhosis on Liver Transplantation (LT) waiting list. Most of these patients have dilutional or hypervolemic hyponatremia secondary to splanchnic vasodilatation. Excessive secretion of the antidiuretic hormone also plays an important role. Hypervolemic hyponatremia is commonly associated with refractory ascites…
  • StatPearls: Syndrome of Inappropriate Antidiuretic Hormone Secretion [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)YasirMuhammadMAllama Iqbal Medical College/JHL, LahoreMechanicOren J.OJHarvard Medical School/BIDMCBOOK
  • Syndrome of inappropriate antidiuretic hormone ADH release (SIADH) is a condition defined by the unsuppressed release of antidiuretic hormone (ADH) from the pituitary gland or nonpituitary sources or its continued action on vasopressin receptors. The condition was first detected in two patients with lung cancer by William Schwartz and Frederic Bartter in 1967. They developed the classic Schwartz …
  • Hydrocephalus-Associated Hyponatremia: A Review. [Review]
    Cureus. 2022 Feb; 14(2):e22427.Li C, Mabry I, … Siddiqi J
  • Hydrocephalus is the pathological accumulation of cerebrospinal fluid within the ventricles of the brain. Hydrocephalus may be broadly divided into three categories: congenital, acquired, or other. Hyponatremia, serum sodium level <135 meq/ml, may be caused by dilution (e.g. syndrome of inappropriate antidiuretic hormone (SIADH)), depletion (e.g. cerebral salt wasting (CSW)), or delusion (e.g. ps…
  • [Hyponatraemia in elderly patient - significance, clarification and therapy]. [Journal Article]
    Dtsch Med Wochenschr. 2022 Mar; 147(6):301-305.Gosch M
  • In the general population, the prevalence of mild, usually asymptomatic hyponatremia ranges from 1,7-7,7 %. With increasing age, it rises to 11,6 % in > 75-year-olds. The prevalence is much higher in nursing home residents and hospital patients. Hyponatremia thus represents the most common electrolyte disturbance in the elderly. Despite the existing evidence on the acute as well as chronic effect…
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