- Cyanide Poisoning and Lactate in Smoke Inhalation. [Journal Article]R I Med J (2013). 2023 Feb 01; 106(1):14-16.RI
- House fires can lead to cyanide poisoning and an associated elevated serum lactate level. Because of delays in obtaining serum cyanide levels, clinical symptoms and serum lactate are often used to guide clinical decision making and antidote administration. However, as this case report identifies, lower levels of serum lactate may in fact correlate with higher levels of serum cyanide that could be…
- Disposable label-free electrochemical immunosensor based on prussian blue nanocubes for four breast cancer tumor markers. [Journal Article]Talanta. 2023 Apr 01; 255:124229.T
- A compact and low-cost multi-electrode array (MEA) is presented, comprising four working electrodes with shared reference and auxiliary electrodes. Prussian blue was electrodeposited on the MEA using chronoamperometry with a positive potential of 0.3 V. Prussian blue nanocubes (PBNCs) were formed, which were observed using scanning electron microscopy. The precision of the four working electrodes…
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- Biomimetic Prussian blue nanozymes with enhanced bone marrow-targeting for treatment of radiation-induced hematopoietic injury. [Journal Article]Biomaterials. 2023 Feb; 293:121980.B
- There is an urgent medical need to develop effective therapies that can ameliorate damage to the radiation-exposed hematopoietic system. Nanozymes with robust antioxidant properties have a therapeutic potential for mitigating radiation-induced hematopoietic injury. However, enhancing nanozyme recruitment to injured tissues in vivo while maintaining their catalytic activity remains a great challen…
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- Hybrid Au-star@Prussian blue for high-performance towards bimodal imaging and photothermal treatment. [Journal Article]J Colloid Interface Sci. 2023 Mar 15; 634:601-609.JC
- In recent years, branched or star-shaped Au nanostructures composed of core and protruding arms have attracted much attention due to their unique optical properties and morphology. As the clinically adapted nanoagent, prussian blue (PB) has recently gained widespread attention in cancer theranostics with potential applications in magnetic resonance (MR) imaging. In this article, we propose a hybr…
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- Dual mode antibacterial surfaces based on Prussian blue and silver nanoparticles. [Journal Article]Dalton Trans. 2023 Jan 03; 52(2):452-460.DT
- Prussian Blue (PB) is an inexpensive, biocompatible, photothermally active material. In this paper, self-assembled monolayers of PB nanoparticles were grafted on a glass surface, protected with a thin layer of silica and decorated with spherical silver nanoparticles. This combination of a photothermally active nanomaterial, PB, and an intrinsically antibacterial one, silver, leads to a versatile …
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- Cyanide within gold mine waste of the free state goldfields: A geochemical modelling approach. [Journal Article]Environ Pollut. 2023 Feb 01; 318:120825.EP
- Cyanide, which remains the preferred chemical used in the gold extraction process, has the potential to be disposed of on goldmine tailings. South Africa has nine goldfields, producing approximately a third of the world's gold to date. The cyanide interacts with metals in the tailings environment, where Prussian blue [Formula: see text] and Turnbull's blue [Formula: see text] are among these. In …
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- Fatalities in Swedish fire-related car crashes from a toxicologic perspective. [Journal Article]Traffic Inj Prev. 2023; 24(1):21-25.TI
- Objective: Vehicle materials developments raise concerns about new patterns of vehicle fire toxic gas emissions. This study aimed to describe toxicologic components in a recent material of fatal car crashes on Swedish roads in which the vehicle caught fire and compare the results to a previous material.Methods: Retrospective registry study. All fatal car crashes with fire in Sweden 2009-2018 were…
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- Copper-rich multifunctional Prussian blue nanozymes for infected wound healing. [Journal Article]Int J Biol Macromol. 2023 Feb 01; 227:1258-1270.IJ
- The healing process of infected wounds was limited by bacterial infection, excessive reactive oxygen species (ROS) accumulation, and tissue hypoxia. In order to alleviate the above situations, herein, a copper-rich multifunctional ultra-small Prussian blue nanozymes (HPP@Cu NZs) was constructed for infected wound synergistic treatment. Firstly, hyaluronic acid was modified by branched polyethylen…
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- Tuning the Fe/Co ratio towards a bimetallic Prussian blue analogue for the ultrasensitive electrochemical sensing of 5-hydroxytryptamine. [Journal Article]Talanta. 2023 Mar 01; 254:124138.T
- Lack of highly efficient, inexpensive, and easily available catalysts severely limits the practical applicability of electrochemically sensing assay towards 5-hydroxytryptamine (5-HT). Herein, four kinds of Fe-Co bimetallic Prussian blue analogues (FeCo-PBAs) with different molar ratios of Fe to Co were prepared using a simple coprecipitation method. Interestingly, Fe(III) in K3 [Fe(CN)6] can be …
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- Reference material of Prussian blue nanozymes for their peroxidase-like activity. [Journal Article]Analyst. 2022 Dec 05; 147(24):5633-5642.A
- Nanozymes with wide applications have rapidly attracted tremendous attention from various fields in the last decade. However, research on the standardization of nanozymes is still lacking. Currently, the accurate evaluation and effective tracing of the enzyme-like activity of nanozymes have become a common concern. This work aims to develop a certified reference material (CRM) of Prussian blue na…
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- Intramuscular Administration of Glyoxylate Rescues Swine from Lethal Cyanide Poisoning and Ameliorates the Biochemical Sequalae of Cyanide Intoxication. [Journal Article]Toxicol Sci. 2022 Nov 03 [Online ahead of print]TS
- Cyanide-a fast-acting poison-is easy to obtain given its widespread use in manufacturing industries. It is a high-threat chemical agent that poses a risk of occupational exposure in addition to being a terrorist agent. FDA-approved cyanide antidotes must be given intravenously, which is not practical in a mass casualty setting due to the time and skill required to obtain intravenous access. Glyox…
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- Application of Prussian Blue in Electrochemical and Optical Sensing of Free Chlorine. [Journal Article]
- In this paper, an electrochemical free chlorine (FCL) sensor was formed by modifying a fluorine-doped tin oxide-coated glass slide (glass|FTO) with a layer of Prussian blue (glass|FTO|PB). The glass|FTO|PB sensor exhibited a wide linear detection range from 1.7 to 99.2 μmol L-1 of FCL with a sensitivity of ~0.8 µA cm-2 μmol-1 L and showed high selectivity for FCL. However, ClO3-, ClO4- and NO3- i…
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- StatPearls: Cobalt Toxicity [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- Cobalt (Co) metal is a gray, ductile, magnetic element with an atomic number of 27 and an atomic weight of 58.9 Da. In the environment, cobalt is a component of naturally occurring minerals and is found in combination with other elements such as copper, nickel, manganese, arsenic, sulfur, and oxygen. Due to its ferromagnetic properties, high melting point (1495.05 C), and high boiling point (2927…
- In Vitro Characterization of a Threonine-Ligated Molybdenyl-Sulfide Cluster as a Putative Cyanide Poisoning Antidote; Intracellular Distribution, Effects on Organic Osmolyte Homeostasis, and Induction of Cell Death. [Journal Article]
- Binuclear molybdenum sulfur complexes are effective for the catalytic conversion of cyanide into thiocyanate. The complexes themselves exhibit low toxicity and high aqueous solubility, which render them suitable as antidotes for cyanide poisoning. The binuclear molybdenum sulfur complex [(thr)Mo2O2(μ-S)2(S2)]- (thr - threonine) was subjected to biological studies to evaluate its cellular accumula…
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- Availability of Antidotes for Management of Acute Toxicity Cases at Emergency Departments in Qassim Hospitals: A Retrospective Study. [Journal Article]
- Drug overdose is a medico-social issue worldwide that may occur intentionally or unintentionally. It is one of the most common reasons for emergency department visits, and it is also a frequent cause of morbidity and mortality globally. This study aims to determine the occurrence of acute toxicity cases and their management outcomes at the emergency departments in Qassim Province hospitals in Sau…
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- Protein-sized nanozymes «artificial peroxidase» based on template catalytic synthesis of Prussian Blue. [Journal Article]Bioelectrochemistry. 2023 Feb; 149:108275.B
- We report on Prussian Blue based nanozymes, comparable in size with a natural enzyme peroxidase. Protein-sized nanoparticles have been synthesized in the course of reduction of ferric ion (Fe3+) and ferricyanide ([Fe(CN)6]3-) one-to-one mixture in reversed micelles (isooctane|AOT|water) used as templates. Aniline chosen as the best reductant for this aim has led to formation of composite (accordi…
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- Advancements of Prussian blue-based nanoplatforms in biomedical fields: Progress and perspectives. [Review]J Control Release. 2022 11; 351:752-778.JC
- Prussian blue (PB) nanoparticles possess excellent physicochemical properties, including imaging features, robust photothermal conversion ability, catalytic activity, surface modifiability, effective drug loading, good stability, biocompatibility and biodegradability. With the advancement of nanotechnology, diverse PB-based nanoplatforms have been developed for biomedical applications. This revie…
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- Identification of Platinum(II) Sulfide Complexes Suitable as Intramuscular Cyanide Countermeasures. [Journal Article]
- The development of rapidly acting cyanide countermeasures using intramuscular injection (IM) represents an unmet medical need to mitigate toxicant exposures in mass casualty settings. Previous work established that cisplatin and other platinum(II) or platinum(IV)-based agents effectively mitigate cyanide toxicity in zebrafish. Cyanide's in vivo reaction with platinum-containing materials was prop…
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- Ultrasensitive multicolor electrochromic sensor built on closed bipolar electrode: Application in the visual detection of Pseudomonas aeruginosa. [Journal Article]Food Chem. 2023 Mar 01; 403:134240.FC
- Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic infection-causing pathogen that threatens human health. Accordingly, a rapid and ultrasensitive analytical method is required urgently. Herein, an ultrasensitive multicolor electrochromic sensing platform was established on the basis of a closed bipolar electrode (BPE). Prussian blue (PB), the blue spot that can be easily electrodeposited…
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- Prussian Blue Staining to Visualize Iron Oxide Nanoparticles. [Journal Article]
- Iron deposits in cells and tissues can be detected by ex vivo histological examination through the Prussian blue (PB) staining. This practical, inexpensive, and highly sensitive technique involves the treatment of fixed tissue sections and cells with acid solutions of ferrocyanides that combine with ferric ion forming a bright blue pigment (i.e., ferric ferrocyanide). The staining can be applied …
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- Dual-template molecularly imprinted electrochemical biosensor for IgG-IgM combined assay based on a dual-signal strategy. [Journal Article]
- Detection of immunoglobulins (Igs) is of clinical significance for early diagnosis and timely treatment of diseases. Herein, a dual-template molecularly imprinted (DTMI) electrochemical biosensor was developed for IgG-IgM combined assay. In this DTMI electrochemical biosensor, Prussian blue (PB) and thionine (TH) decorated on graphene oxide (GO) and multi-walled carbon nanotubes (MWCNTs), respect…
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- Size-effect on the intracellular antioxidative activity of Prussian blue nanoparticles investigated by atomic force microscopy. [Journal Article]Anal Chim Acta. 2022 Sep 22; 1227:340321.AC
- Nanoparticles-based antioxidative therapy has been highlighted in a series of diseases triggered by excessive reactive oxygen species (ROS). Prussian blue nanoparticles (PBNPs), as a representative artificial nanozyme, have been proved as highly effective ROS scavengers. However, its detailed intracellular antioxidant mechanism is not clear yet. Herein, a series of PBNPs with different particle s…
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- Bimetallic FeMn@C derived from Prussian blue analogue as efficient nanozyme for glucose detection. [Journal Article]Anal Bioanal Chem. 2022 Nov; 414(27):7773-7782.AB
- In recent decades, nanomaterial-based artificial enzymes called nanozymes have received more and more attention and have been applied in biological, chemical, medical, and other fields. In this work, bimetallic FeMn@C was synthesized by calcination from the Prussian blue analogue. The synthesized bimetallic FeMn@C exhibits efficient peroxidase-like activity. The effect of Mn doping amount, cataly…
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- Scalable Printing of Prussian Blue Analogue@Au Edge-Rich Microcubes as Flexible Biosensing Microchips Performing Ultrasensitive Sucrose Fermentation Monitoring. [Journal Article]ACS Appl Mater Interfaces. 2022 Sep 14; 14(36):40569-40578.AA
- Sucrose is one of the most applied carbon sources in the fermentation process, and it directly determines the microbial metabolism with its concentration fluctuation. Meanwhile, sucrose also plays a key role of a protective agent in the production of biological vaccines, especially in the new mRNA vaccines for curing COVID-19. However, rapid and precise detection of sucrose is always desired but …
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- A Redox-Probe-Free Immunosensor Based on Electrocatalytic Prussian Blue Nanostructured Film One-Step-Prepared for Zika Virus Diagnosis. [Journal Article]
- The Zika virus (ZIKV) is a great concern for global health due to its high transmission, including disseminating through blood, saliva, urine, semen and vertical transmission. In some cases, ZIKV has been associated with microcephaly, neurological disorders, and Guillain-Barré syndrome. There is no vaccine, and controlling the disease is a challenge, especially with the co-circulation of the Deng…
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- Electrochemical determination of acetamiprid using PEDOT sensing coating functionalized with carbon quantum dots and Prussian blue nanoparticles. [Journal Article]Mikrochim Acta. 2022 08 23; 189(9):341.MA
- A dual-mode electrochemical biosensor for acetamiprid detection was proposed for the first time based on carbon quantum dots/Prussian blue (CQDs/PB)-functionalized poly(3,4-ethylenedioxythiphene) (PEDOT) nanocomposite. The nanocomposite with spherical stacking nanostructure showed high surface area, excellent catalytic ability, and cycling stability. The biosensor can be effortlessly constructed …
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- Rust stains' response to environmental stresses: An experimental study on porcine skin. [Journal Article]J Forensic Leg Med. 2022 Oct; 91:102402.JF
- Rust stains are rare marks typically caused by prolonged contact between skin and the iron components of the firearm. This study was aimed at showing how cutaneous iron deposits respond to physical and chemical changes that usually affect the integrity of biological tissues. Four samples of porcine skin were placed in contact with an iron plate. They were exposed to different stress conditions: c…
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- Reactive oxygen species scavenging nanofibers with chitosan-stabilized Prussian blue nanoparticles for enhanced wound healing efficacy. [Journal Article]
- Chronic inflammatory wounds pose therapeutic challenges in the biomedical field. Polymeric nanofibrous matrices provide extracellular-matrix-like structures to facilitate wound healing; however, wound infection and the subsequent accumulation of reactive oxygen species (ROS) delay healing. Therefore, we herein developed electrospun nanofibers (NFs), composed of chitosan-stabilized Prussian blue (…
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- Analysis of bisaminotetrazole cobinamide, a next-generation antidote for cyanide, hydrogen sulfide and methanethiol poisoning, in swine plasma by liquid chromatography-tandem mass spectrometry. [Journal Article]J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Oct 01; 1208:123392.JC
- Cyanide, hydrogen sulfide, and methanethiol are common toxic inhalation agents that inhibit mitochondrial cytochrome c oxidase and result in cellular hypoxia, cytotoxic anoxia, apnea, respiratory failure, cardiovascular collapse, seizure and potentially death. While all are occupational gas exposure hazards that have the potential to cause mass casualties from industrial accidents or acts of terr…
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- Chemical and electrochemical conversion of magnetic nanoparticles to Prussian blue for label-free and refreshment-enhanced electrochemical biosensing of enrofloxacin. [Journal Article]
- Magnetic biosensor takes advantage of rapid and facile magnetic separation/collection of targets, however, generally relies on additional signal labels to generate signal in a tedious and high-cost way. Here, we proposed a chemical and electrochemical conversion (C-ECC) method to develop a label-free electrochemical magnetic biosensor to detect antibiotics enrofloxacin (ENR). The C-ECC method int…
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