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429,403 results
  • Azathioprine Induced Pancytopenia in a Patient with Vogt-Koyanagi-Harada Disease: A Case Report. [Case Reports]
    JNMA J Nepal Med Assoc. 2022 Oct 01; 60(254):902-905.Khatri S, Khatri S, … Singh AK
  • Vogt-Koyanagi-Harada disease is a multisystem autoimmune inflammatory disorder that affects the eyes, ears, skin, and the nervous system. It is a rare disease that mainly affects Asian, Hispanic, and Middle Eastern populations. Systemic steroids and immunosuppressants are frequently used to treat autoimmune diseases like this. Despite the fact that they reduce morbidity, immunosuppressants can ha…
  • Antimetabolite in the Management of Odontogenic Keratocyst-A Case Report. [Case Reports]
    J Maxillofac Oral Surg. 2023 Mar; 22(1):132-135.Banala P, Reddy GS, … Bhavani M
  • Odontogenic keratocyst (OKC) is an aggressive cystic lesion of the jaw with high growth and recurrence. Patients are usually asymptomatic and detected during routine radiographic examination. Management of OKC varies from conservative procedures like simple Enucleation and peripheral ostectomy to aggressive resection. More attention is given to new treatment protocols to form them simple and succ…
  • Methotrexate and Triptolide regulate Notch signaling pathway by targeting the Nedd4-Numb axis. [Journal Article]
    Int Immunopharmacol. 2023 Jan; 114:109595.Wu Q, Chen X, … Zheng H
  • Methotrexate (MTX) is used to treat rheumatoid arthritis, acute leukemia, and psoriasis. MTX can cause certain side effects, such as myelosuppression, while the exact mechanism of myelosuppression caused by MTX is unknown. Notch signaling pathway has been considered to be essential to regulate hematopoietic stem cell (HSC) regeneration and homeostasis, thus contributing to bone marrow hematopoies…
  • Alleviative effects of glutamate against chemotherapeutic agent-induced intestinal mucositis. [Journal Article]
    J Physiol Pharmacol. 2022 Aug; 73(4)Jonan S, Hamouda N, … Amagase K
  • 5-Fluorouracil (5-FU) is one of the most widely used chemotherapeutic agents; however, it often causes intestinal mucositis with severe diarrhea. An efficient treatment strategy to reduce this side effect is lacking. Glutamate (Glu), a nonessential amino acid, is the most important energy source in the small intestine and has been shown to maintain intestinal morphology, barrier function, and ant…
  • Remdesivir for the treatment of COVID-19. [Review]
    Cochrane Database Syst Rev. 2023 Jan 25; 1(1):CD014962.Grundeis F, Ansems K, … Stegemann M
  • CONCLUSIONS: Based on the available evidence up to 31 May 2022, remdesivir probably has little or no effect on all-cause mortality or in-hospital mortality of individuals with moderate to severe COVID-19. The hospitalisation rate was reduced with remdesivir in one study including participants with mild to moderate COVID-19. It may be beneficial in the clinical course for both hospitalised and non-hospitalised patients, but certainty remains limited. The applicability of the evidence to current practice may be limited by the recruitment of participants from mostly unvaccinated populations exposed to early variants of the SARS-CoV-2 virus at the time the studies were undertaken.  Future studies should provide additional data on the efficacy and safety of remdesivir for defined core outcomes in COVID-19 research, especially for different population subgroups.
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