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(Antiparkinsonian drugs anticholinergic)
3,443 results
  • Trihexyphenidyl for dystonia in cerebral palsy. [Review]
  • CDCochrane Database Syst Rev 2018 May 15; 5:CD012430
  • Harvey AR, Baker LB, … Williams K
  • CONCLUSIONS: At present, there is insufficient evidence regarding the effectiveness of trihexyphenidyl for people with cerebral palsy for the outcomes of: change in dystonia, adverse effects, increased upper limb function and improved participation in activities of daily living. The study did not measure pain or quality of life. There is a need for larger randomised, controlled, multicentre trials that also examine the effect on pain and quality of life in order to determine the effectiveness of trihexyphenidyl for people with cerebral palsy.
  • Anticholinergic drugs and risk of dementia: case-control study. [Journal Article]
  • BMJBMJ 2018 Apr 25; 361:k1315
  • Richardson K, Fox C, … Savva GM
  • CONCLUSIONS: A robust association between some classes of anticholinergic drugs and future dementia incidence was observed. This could be caused by a class specific effect, or by drugs being used for very early symptoms of dementia. Future research should examine anticholinergic drug classes as opposed to anticholinergic effects intrinsically or summing scales for anticholinergic exposure.
  • Misuse of Trihexyphenidyl (Artane) on Réunion Island. [Journal Article]
  • JCJ Clin Psychopharmacol 2018; 38(3):250-253
  • Torrents R, Ferré JF, … Scerra S
  • CONCLUSIONS: This cohort describing the clinical characteristics of 69 patients is the largest cohort studied for THP addiction. Patients from the Centres for Addiction Prevention and Treatment were the youngest and most recently addicted, whereas general practice patients had been addicted for longer and were more socially integrated. This clinical description of THP addiction therefore enables us to identify the patients who are the most at risk, to set up an adapted care protocol.
  • Disabling tremor induced by long-term use of sodium valproate and lamotrigine: Case report. [Case Reports]
  • MMedicine (Baltimore) 2017; 96(47):e8711
  • He ZF, Chen J, … Wang XH
  • CONCLUSIONS: Considering the wide and long-term utilization of VPA and LTG, healthcare providers should be aware of them as a possible cause of tremor. When necessary, an attempt of discontinuing the suspected drugs should be made to confirm the diagnosis, instead of symptomatic treatment, especially when the adverse event was severe and fatal.
  • Anticholinergic medication for antipsychotic-induced tardive dyskinesia. [Review]
  • CDCochrane Database Syst Rev 2018 01 17; 1:CD000204
  • Bergman H, Soares-Weiser K
  • CONCLUSIONS: Based on currently available evidence, no confident statement can be made about the effectiveness of anticholinergics to treat people with antipsychotic-induced tardive dyskinesia. The same applies for the withdrawal of such medications. Whether the withdrawal of anticholinergics may benefit people with antipsychotic-induced TD should be evaluated in a parallel-group, placebo-controlled randomised trial, with adequate sample size and at least 6 weeks of follow-up.
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