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Unbound Medicine.
(Antiretroviral therapy)
109,797 results
  • Vascular dysfunction and body mass index in African adults with HIV. [Journal Article]
    BMC Cardiovasc Disord. 2023 Feb 03; 23(1):64.Kaluba L, Chikopela T, … Koethe JR
  • CONCLUSIONS: Underweight PWH in SSA had lower cfAIX measurements compared to normal weight individuals, indicating less arterial stiffness. However, similar cfPWV, crPWV and crAIX values among the underweight and overweight PWH suggest a low BMI may not confer substantial protection against impaired vascular compliance as a contributor to CVD risk among individuals on ART.
  • Perspectives of people living with HIV age 50 and over regarding barriers and resources for care. [Journal Article]
    AIDS Care. 2023 Feb 03 [Online ahead of print]Davis AJ, Greene M, … Erlandson KM
  • ABSTRACTWith early and effective antiretroviral therapy leading to improved life expectancy in people with HIV (PWH), PWH aged 50 or older face concerns and issues related to aging. Providers at the University of Colorado identified a need to assess the healthcare needs of PWH aged 50 and older at the UCHealth Infectious Diseases/Travel (TEAM) Clinic in Aurora, Colorado. A survey was developed to…
  • PolyIC-coated Prussian blue nanoparticles as a dual-mode HIV latency reversing agent. [Journal Article]
    Nanomedicine (Lond). 2023 Feb 03 [Online ahead of print]Balakrishnan PB, Holmberg CS, … Fernandes R
  • Aim: To investigate Prussian blue nanoparticles (PBNPs) coated with the synthetic analog of dsRNA polyinosinic-polycytidylic acid (polyIC) for their ability to function as HIV latency reversing agents. Methods: A layer-by-layer method was used to synthesize polyIC-coated PBNPs (polyIC-PBNPs). PolyIC-PBNPs were stable and monodisperse, maintained the native absorbance properties of both polyIC and…
  • Pre-Pandemic Predictors of Medication Adherence and HIV Viral Load During the First Year of COVID-19. [Journal Article]
    J Acquir Immune Defic Syndr. 2022 Nov 03 [Online ahead of print]Kalichman SC, Eaton LA, … Caliendo AM
  • Studies have reported significant immediate impacts of the COVID-19 pandemic on the social relationships and healthcare of people living with HIV. This study followed a closed cohort of young people living with HIV over the first year of the COVID-19 pandemic. Participants were men and women (N = 140) age 36 and younger who were living with HIV and had demonstrated suboptimal adherence to antiret…
  • Antiretroviral Options and Treatment Decisions During Pregnancy. [Review]
    Paediatr Drugs. 2023 Feb 02 [Online ahead of print]Poliektov NE, Badell ML
  • The majority of pediatric human immunodeficiency virus (HIV) infections are the result of vertical transmissions that occur during pregnancy, childbirth, and breastfeeding. The treatment of all pregnant persons living with HIV remains a global health initiative. Early and consistent use of antiretroviral therapy throughout pregnancy and childbirth drastically reduces the risk of perinatal transmi…
  • Cannabis Use Is Associated With Decreased Antiretroviral Therapy Adherence Among Older Adults With HIV. [Journal Article]
    Open Forum Infect Dis. 2023 Jan; 10(1):ofac699.Manuzak JA, Granche J, … AIDS Clinical Trials Group (ACTG) A5322 Study Team
  • CONCLUSIONS: Among a cohort of older PWH, current cannabis users had a higher risk of <100% ART adherence compared to nonusers. These findings have important clinical implications as suboptimal ART adherence is associated with ART drug resistance, virologic failure, and elevated risk for mortality. Further research is needed to elucidate the mechanisms by which cannabis use decreases ART adherence in older PWH and to advance the development of more efficacious methods to mitigate nonadherence in this vulnerable population.
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