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(Antiretroviral therapy)
55,336 results
  • Community delivery of antiretroviral drugs: A non-inferiority cluster-randomized pragmatic trial in Dar es Salaam, Tanzania. [Journal Article]
  • PMPLoS Med 2018; 15(9):e1002659
  • Geldsetzer P, Francis JM, … Bärnighausen T
  • CONCLUSIONS: In this study, an ARV community delivery model performed at least as well as the standard of care regarding the critical health indicator of virological failure. The intervention did not significantly reduce patient healthcare expenditures, but satisfaction with the program was high and it is likely to save patients time. Policy-makers should consider piloting, evaluating, and scaling more ambitious ARV community delivery programs that can reach higher proportions of ART patients.
  • Forecasting the global demand for HIV monitoring and diagnostic tests: A 2016-2021 analysis. [Journal Article]
  • PlosPLoS One 2018; 13(9):e0201341
  • Habiyambere V, Dongmo Nguimfack B, … NeSmith T
  • CONCLUSIONS: In order to achieve the ambitious 90-90-90 targets, it will be essential to maintain and improve access to CD4, VL, EID tests and RDTs. These projections provide insight into the global demand we can expect to see for these HIV monitoring and diagnostic tests, both in relation to historical trends, and the 90-90-90 targets. Our projections will better enable producers to ensure adequate supply, and to support procurement organisations in planning future funding and purchase plans to meet the anticipated demand. The findings highlight the ongoing need for governments and international funding bodies to prioritise improving capacity and access to HIV diagnostic and monitoring technologies in line with demand.
  • Substance use patterns and HIV-1 RNA viral load rebound among HIV-positive illicit drug users in a Canadian setting. [Journal Article]
  • ATAntivir Ther 2018 Sep 19
  • Ladak F, Socias E, … Milloy MJ
  • CONCLUSIONS: The present study suggests that in addition to heavy alcohol use, high-intensity illicit drug use, particularly ≥daily heroin injection and ≥daily crack smoking are risk factors for VL rebound. In addition to the impact of high-intensity drug use on healthcare engagement and ART adherence, some evidence exists on the direct impact of psychoactive substances on ART metabolism and the natural progression of HIV disease. At-risk individuals should be provided additional supports to preserve virologic control and maintain the benefits of ART.
  • Virological failure among adolescents on ART, Harare City, 2017- a case-control study. [Journal Article]
  • BIBMC Infect Dis 2018 Sep 18; 18(1):469
  • Sithole Z, Mbizvo E, … Tshimanga M
  • CONCLUSIONS: Poor adherence, alcohol consumption and non-disclosure increased the odds of virological failure. Based on these findings support should focus on behavior change and strengthening of peer to peer projects to help address issues related to disclosure and adherence. Further operational research should aim to define other components of effective adherence support for adolescents with virological failure.
  • Detecting spatial clusters of HIV and hepatitis coinfections. [Journal Article]
  • PlosPLoS One 2018; 13(9):e0203674
  • Das S, Opoku J, … Kharfen M
  • CONCLUSIONS: We identified locations of high risk clusters where enhanced hepatitis and HIV prevention, treatment, and care can help combat the epidemic. The clusters radius expands into the neighboring state of Maryland as well. The findings from this analysis will be used to target area based public health policy and healthcare interventions for HIV-hepatitis. It is recommended based on the analysis that needle exchange programs can successfully control new HIV infections as well as hepatitis co-infections.
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