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378 results
  • Formulation and in-silico study of meclizine ointment as anti-eczema. [Journal Article]
    In Silico Pharmacol. 2022; 10(1):15.Al-Madhagi WM, Alzomor AKY, … Mubarak MA
  • Meclizine is antihistamine and is used in combination with pyridoxine to treat motion sickness. The in-silico study of meclizine prediction studied showed that meclizine has anti-eczema activity with possible activity 95. This research aimed to explore the anti-eczema activity of meclizine. Therefore, five formulations of meclizine ointment have been prepared using different bases (white base, si…
  • StatPearls: Meclizine [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)HoustonBobby T.BTRoss University School of medicineChowdhuryYuvraj S.YSState University of New York - DownstateBOOK
  • Meclizine is a medication used to manage and treat nausea, vomiting, and dizziness caused by motion sickness and vertigo. Meclizine belongs to a drug class called antihistamines, which are often used to treat allergies. This activity will review the indications, method of action, contraindications, and other key features for meclizine, as a valuable agent in the therapy for motion sickness and ve…
  • Benign paroxysmal positional vertigo: A practical approach for emergency physicians. [Journal Article]
    Acad Emerg Med. 2022 Jul 14 [Online ahead of print]Edlow JA, Kerber K
  • Benign paroxysmal positional vertigo (BPPV) is a very common condition in the population and an important cause of acute vertigo or dizziness in patients presenting to an emergency department (ED). Despite this, abundant evidence shows that current ED management of patients with BPPV is suboptimal. Common ED management processes include brain imaging and treatment with vestibular suppressant medi…
  • Novel use of FDA-approved drugs identified by cluster analysis of behavioral profiles. [Journal Article]
    Sci Rep. 2022 04 21; 12(1):6120.Tucker Edmister S, Del Rosario Hernández T, … Creton R
  • Repurposing FDA-approved drugs is an efficient and cost-effective approach in the development of therapeutics for a broad range of diseases. However, prediction of function can be challenging, especially in the brain. We screened a small-molecule library with FDA-approved drugs for effects on behavior. The studies were carried out using zebrafish larvae, imaged in a 384-well format. We found that…
  • Understanding flow chemistry for the production of active pharmaceutical ingredients. [Review]
    iScience. 2022 Mar 18; 25(3):103892.Burange AS, Osman SM, Luque R
  • Multi-step organic syntheses of various drugs, active pharmaceutical ingredients, and other pharmaceutically and agriculturally important compounds have already been reported using flow synthesis. Compared to batch, hazardous and reactive reagents can be handled safely in flow. This review discusses the pros and cons of flow chemistry in today's scenario and recent developments in flow devices. T…
  • Impurity-profiling UPLC methods for quantitative analysis of some antiemetics formulated with pyridoxine. [Journal Article]
    Biomed Chromatogr. 2022 Jun; 36(6):e5353.Saad AS, Draz ME, … Abdallah FF
  • Cyclizine hydrochloride (CYC) and meclozine hydrochloride (MEC) are antihistaminic drugs generally co-formulated with pyridoxine hydrochloride (PYR) to treat nausea and vomiting in pregnancy. Several analytical techniques have been applied for the determination of CYC or MEC with PYR, but determination of CYC impurity; benzhydrol (BEH) or MEC impurity; or 4-chlorobenzophenone (BEP) has not been p…
  • Meclozine ameliorates skeletal muscle pathology and increases muscle forces in mdx mice. [Journal Article]
    Biochem Biophys Res Commun. 2022 02 12; 592:87-92.Kawamura Y, Hida T, … Ohno K
  • We screened pre-approved drugs for the survival of the Hu5/KD3 human myogenic progenitors. We found that meclozine, an anti-histamine drug that has long been used for motion sickness, promoted the proliferation and survival of Hu5/KD3 cells. Meclozine increased expression of MyoD, but reduced expression of myosin heavy chain and suppressed myotube formation. Withdrawal of meclozine, however, resu…
  • Systems biomarkers for papillary thyroid cancer prognosis and treatment through multi-omics networks. [Meta-Analysis]
    Arch Biochem Biophys. 2022 01 15; 715:109085.Gulfidan G, Soylu M, … Turanli B
  • The identification of biomolecules associated with papillary thyroid cancer (PTC) has upmost importance for the elucidation of the disease mechanism and the development of effective diagnostic and treatment strategies. Despite particular findings in this regard, a holistic analysis encompassing molecular data from different biological levels has been lacking. In the present study, a meta-analysis…
  • Drugs and Lactation Database (LactMed): Meclizine [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Occasional doses of meclizine are probably acceptable during breastfeeding. Large doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established.
  • Mother To Baby | Fact Sheet: Meclizine [BOOK]
    Mother To Baby | Fact Sheet. Organization of Teratology Information Specialists (OTIS): BrentwoodBOOK
  • This sheet is about exposure to meclizine in pregnancy and while breastfeeding. This information should not take the place of medical care and advice from your healthcare providers.
  • Novel mTORC1 Inhibitors Kill Glioblastoma Stem Cells. [Journal Article]
    Pharmaceuticals (Basel). 2020 Nov 24; 13(12)Sandoval JA, Tomilov A, … Cortopassi G
  • Glioblastoma (GBM) is an aggressive tumor of the brain, with an average post-diagnosis survival of 15 months. GBM stem cells (GBMSC) resist the standard-of-care therapy, temozolomide, and are considered a major contributor to tumor resistance. Mammalian target of rapamycin Complex 1 (mTORC1) regulates cell proliferation and has been shown by others to have reduced activity in GBMSC. We recently i…
  • Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis. [Meta-Analysis]
    Cochrane Database Syst Rev. 2020 Oct 19; 10(10):CD012859.Weibel S, Rücker G, … Kranke P
  • CONCLUSIONS: We found high-certainty evidence that five single drugs (aprepitant, ramosetron, granisetron, dexamethasone, and ondansetron) reduce vomiting, and moderate-certainty evidence that two other single drugs (fosaprepitant and droperidol) probably reduce vomiting, compared to placebo. Four of the six substance classes (5-HT₃ receptor antagonists, D₂ receptor antagonists, NK₁ receptor antagonists, and corticosteroids) were thus represented by at least one drug with important benefit for prevention of vomiting. Combinations of drugs were generally more effective than the corresponding single drugs in preventing vomiting. NK₁ receptor antagonists were the most effective drug class and had comparable efficacy to most of the drug combinations. 5-HT₃ receptor antagonists were the best studied substance class. For most of the single drugs of direct interest, we found only very low to low certainty evidence for safety outcomes such as occurrence of SAEs, any AE, and substance class-specific side effects. Recommended and high doses of granisetron, dexamethasone, ondansetron, and droperidol were more effective than low doses for prevention of vomiting. Dose dependency of side effects was rarely found due to the limited number of studies, except for the less sedating effect of recommended and high doses of ondansetron. The results of the review are transferable mainly to patients at higher risk of nausea and vomiting (i.e. healthy women undergoing inhalational anaesthesia and receiving perioperative opioids). Overall study quality was limited, but certainty assessments of effect estimates consider this limitation. No further efficacy studies are needed as there is evidence of moderate to high certainty for seven single drugs with relevant benefit for prevention of vomiting. However, additional studies are needed to investigate potential side effects of these drugs and to examine higher-risk patient populations (e.g. individuals with diabetes and heart disease).
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