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Unbound Medicine.
(Antiviral agents topical ophthalmic)
829 results
  • The Management of Ocular Surface Squamous Neoplasia (OSSN). [Review]
    Int J Mol Sci. 2022 Dec 31; 24(1)Yeoh CHY, Lee JJR, … Lim CHL
  • The rise of primary topical monotherapy with chemotherapeutic drugs and immunomodulatory agents represents an increasing recognition of the medical management of ocular surface squamous neoplasia (OSSN), which may replace surgery as the standard of care in the future. Currently, there is no consensus regarding the best way to manage OSSN with no existing guidelines to date. This paper seeks to ev…
  • The use of antivirals in the treatment of human monkeypox outbreaks: a systematic review. [Review]
    Int J Infect Dis. 2023 Feb; 127:150-161.Shamim MA, Padhi BK, … Chattu VK
  • CONCLUSIONS: Tecovirimat is the most used and has proven beneficial in several aggravating cases. No major safety concerns were detected upon its use. Topical trifluridine was used as an adjuvant treatment option along with tecovirimat. BCV and cidofovir were seldom used, with the latter often being used due to the unavailability of tecovirimat. BCV was associated with treatment discontinuation due to adverse events.
  • Corneal Complications after COVID-19 Vaccination: A Systemic Review. [Review]
    J Clin Med. 2022 Nov 18; 11(22)Huang LY, Chiang CC, … Tsai YY
  • Multiple vaccines are now being used across the world, and several studies have described cases of corneal graft rejection following the administration of the COVID-19 vaccine. The purpose of this article is to review the corneal adverse event that occurred following COVID-19 vaccine administration. The literature search was conducted in March 2022 using MEDLINE, PubMed, and the Cochrane Database…
  • Viral Infection and Antiviral Treatments in Ocular Pathologies. [Review]
    Microorganisms. 2022 Nov 10; 10(11)Petrillo F, Petrillo A, … Galdiero M
  • Ocular viral infections are common and widespread globally. These infectious diseases are a major cause of acute red eyes and vision loss. The eye and its nearby tissues can be infected by several viral agents, causing infections with a short course and limited ocular implications or a long clinical progression and serious consequences for the function and structure of the ocular region. Several …
  • Ocular Monkeypox - United States, July-September 2022. [Journal Article]
    MMWR Morb Mortal Wkly Rep. 2022 Oct 21; 71(42):1343-1347.Cash-Goldwasser S, Labuda SM, … CDC Monkeypox Clinical Escalations Team
  • As of October 11, 2022, a total of 26,577 monkeypox cases had been reported in the United States.* Although most cases of monkeypox are self-limited, lesions that involve anatomically vulnerable sites can cause complications. Ocular monkeypox can occur when Monkeypox virus (MPXV) is introduced into the eye (e.g., from autoinoculation), potentially causing conjunctivitis, blepharitis, keratitis, a…
  • In vitro activity of cysteamine against SARS-CoV-2 variants. [Journal Article]
    Mol Genet Metab. 2022 Sep-Oct; 137(1-2):192-200.Thoene J, Gavin RF, … Pal R
  • Global COVID-19 pandemic is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Continuous emergence of new variants and their rapid spread are jeopardizing vaccine countermeasures to a significant extent. While currently available vaccines are effective at preventing illness associated with SARS-CoV-2 infection, these have been shown to be less effective at pre…
  • Intensive topical interferon therapy in uveitic macular edema. [Journal Article]
    Indian J Ophthalmol. 2022 08; 70(8):2986-2989.Kawali A, Sanjay S, … Shetty R
  • CONCLUSIONS: Intensive topical IFN therapy can be an alternative therapeutic option in the treatment of UME. Study of intraocular penetration, combination with other drugs, and the efficacy of IFN separately for different uveitic entities may explore new avenues in treatment of UME.
  • [Two cases of herpes simplex keratitis after trans-epithelial photorefractive keratectomy]. [Case Reports]
    Zhonghua Yan Ke Za Zhi. 2022 Jun 11; 58(6):448-452.Wu XX, Yu CJ, … Zhang LJ
  • We herein report 2 cases of herpes simplex keratitis after trans-epithelial photorefractive keratectomy. Patients' medical histories, symptoms, signs, clinical examination results, diagnosis and treatment were showed in detail. Following precision diagnosis and medical intervention, including topical and systemic antiviral treatmented for 1 to 2 weeks. The two patients were cured with full reepit…
  • A Case Report of Herpes Zoster Ophthalmicus and Meningitis After COVID-19 Vaccination. [Case Reports]
    J Korean Med Sci. 2022 May 23; 37(20):e165.You IC, Ahn M, Cho NC
  • There are several reports that herpes zoster characterized by reactivation of varicella zoster virus (VZV) following coronavirus disease 2019 (COVID-19) vaccines can occur. Herein, we report VZV meningitis, herpes zoster ophthalmicus (HZO), and late neurotrophic keratitis after receiving a second dose of messenger RNA (mRNA) COVID-19 vaccine. A 74-year-old man developed a vesicular skin rash on t…
  • StatPearls: Herpes Simplex Ophthalmicus [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)KanukolluVenkata M.VMDarlington Memorial HospitalPatelBhupendra C.BCUniversity of UtahBOOK
  • Herpes simplex ophthalmicus (HSO) is caused by the neurotropic herpes simplex virus type 1 and type 2 and affects all the structures of the eye. Primary infection occurs in the form of blepharoconjunctivitis both in neonates through birth canal transmission and in children through orofacial mucus membrane transmission. Primary infection is often self-limiting, and the virus ascends through the cu…
  • Long-Acting Protective Ocular Surface by Instilling Adhesive Dual-Antiviral Nanoparticles. [Journal Article]
    Adv Healthc Mater. 2022 07; 11(14):e2200283.Wang X, Chen L, … Pang Y
  • The eye is susceptible to viral infections, causing severe ocular symptoms or even respiratory diseases. Methods capable of protecting the eye from external viral invasion in a long-term and highly effective way are urgently needed but have been proved to be extremely challenging. Here, a strategy of forming a long-acting protective ocular surface is described by instilling adhesive dual-antivira…
  • Amniotic Membrane Grafting for Ocular Surface Inflammation Following Topical Interferon Alpha 2b Therapy. [Case Reports]
    J Interferon Cytokine Res. 2022 03; 42(3):137-139.Shah SG, Mishra DK, Shah GY
  • We describe a rare case of a 58-year-old female with ocular surface squamous neoplasia (OSSN) in her left eye. She was treated for 12 months with topical interferon alpha-2b (IFNα-2b) eye drops and OSSN resolved completely. She presented with a whitish elevated lesion involving the cornea, limbus, and conjunctival surface after discontinuation of topical IFNα-2b. Excision biopsy along with amniot…
  • Topical pharmacologic interventions versus placebo for epidemic keratoconjunctivitis. [Review]
    Cochrane Database Syst Rev. 2022 03 03; 3:CD013520.Liu SH, Hawkins BS, … Kuo IC
  • CONCLUSIONS: The evidence for the seven specified outcomes was of low or very low certainty due to imprecision and high risk of bias. The evidence that antiviral agents shorten the duration of symptoms or signs when compared with artificial tears was inconclusive. Low certainty evidence suggests that PVP-I alone resolves signs and symptoms by seven days relative to artificial tears. PVP-I or PVA-I, alone or with steroid, is associated with lower risks of SEI development than artificial tears or steroid (very low certainty evidence). The currently available evidence is insufficient to determine whether any of the evaluated interventions confers an advantage over steroids or artificial tears with respect to virus eradication or its spread to initially uninvolved fellow eyes. Future updates of this review should provide evidence of high-level certainty from trials with larger sample sizes, enrollment of participants with similar durations of signs and symptoms, and validated methods to assess short- and long-term outcomes.
  • Acute retinal necrosis: time to consider double dose of Foscarnet in the first 72 hours. [Case Reports]
    Rom J Ophthalmol. 2021 Jul-Sep; 65(3):267-270.Hermoso-Fernández FM, Gonzalez-Gallardo C, Cruz-Rojo M
  • Purpose: To report a case of acute retinal necrosis (ARN) and to emphasize special aspects of the management. Factors that must be considered. Methods: We present the case of an 83-year-old woman examined for acute vision loss in her left eye (LE). Background: diabetes, pseudophakic in her LE; subluxated intraocular lens (IOL) and advanced pseudoexfoliative glaucoma in her right eye (RE). The vis…
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