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1,257 results
  • Enhanced abatement of pharmaceuticals by permanganate via the addition of Co3O4 nanoparticles. [Journal Article]
    Chemosphere. 2021 Nov; 282:131115.Wang D, Zhang H, … Zhang J
  • Pharmaceuticals may pose serious potential risks, such as biological responses and chronic health effects, due to their ubiquitous in natural aquatic water bodies. In this study, we proposed an effective, feasible, and low-cost strategy for the abatement of pharmaceuticals (i.e., phenylbutazone (PBZ) and sulfinpyrazone (SPZ)) via Co3O4 nanoparticles (NPs) as heterogeneous catalyst in permanganate…
  • UDP-glycosyltransferases contribute to spirotetramat resistance in Aphis gossypii Glover. [Review]
    Pestic Biochem Physiol. 2020 Jun; 166:104565.Pan Y, Wen S, … Shang Q
  • Uridine diphosphate (UDP)-glycosyltransferases (UGTs) catalyze the conjugation of small lipophilic endogenous and exogenous compounds with sugars to produce water-soluble glycosides, playing an important role in insect endobiotic regulation and xenobiotic detoxification. In this study, two UGT-inhibitors, sulfinpyrazone and 5-nitrouracil, significantly increased spirotetramat toxicity against thi…
  • Safety and tolerability of available urate-lowering drugs: a critical review. [Review]
    Expert Opin Drug Saf. 2019 04; 18(4):261-271.Strilchuk L, Fogacci F, Cicero AF
  • Urate-lowering therapy (ULT) is the cornerstone of gout management, which is a widespread chronic illness characterized by hyperuricemia, arthropathy, tophus development, and urolithiasis. Since asymptomatic increased serum urate levels are associated with a higher risk of cardiovascular, renal and metabolic disorders, a larger use of ULTs in the general population is expected in the near future.
  • An Ex Vivo Fermentation Screening Platform to Study Drug Metabolism by Human Gut Microbiota. [Journal Article]
    Drug Metab Dispos. 2018 11; 46(11):1596-1607.van de Steeg E, Schuren FHJ, … Vaes WHJ
  • Colon microbiota-based drug metabolism has received little attention thus far in the process of drug development, whereas the role of gut microbiota in clinical safety and efficacy of drugs has become more clear. Many of these studies have been performed using animal studies, but the translational value of these data with respect to drug pharmacokinetics, efficacy, and safety is largely unknown. …
  • Effects of Discontinuation of Urate-Lowering Therapy: A Systematic Review. [Journal Article]
    J Gen Intern Med. 2018 03; 33(3):358-366.Beslon V, Moreau P, … Fournier JP
  • Urate-lowering therapy (ULT) is associated with low rates of adherence, leading to a potential risk of relapse of gouty arthritis, tophi, or urolithiasis. Our main aim was to identify the recurrence of gouty arthritis, tophi, or urolithiasis after discontinuation of ULT. Secondary aims included an assessment of ULT reintroduction rates and factors associated with relapse.
  • Vitamin C modulates glutamate transport and NMDA receptor function in the retina. [Journal Article]
    J Neurochem. 2018 02; 144(4):408-420.Domith I, Socodato R, … Paes-de-Carvalho R
  • Vitamin C (in the reduced form ascorbate or in the oxidized form dehydroascorbate) is implicated in signaling events throughout the central nervous system (CNS). In the retina, a high-affinity transport system for ascorbate has been described and glutamatergic signaling has been reported to control ascorbate release. Here, we investigated the modulatory role played by vitamin C upon glutamate upt…
  • Vitamin C Facilitates Demethylation of the Foxp3 Enhancer in a Tet-Dependent Manner. [Journal Article]
    J Immunol. 2016 Mar 01; 196(5):2119-31.Sasidharan Nair V, Song MH, Oh KI
  • Demethylation of CpG motifs in the Foxp3 intronic element, conserved noncoding sequence 2 (CNS2), is indispensable for the stable expression of Foxp3 in regulatory T cells (Tregs). In this study, we found that vitamin C induces CNS2 demethylation in Tregs in a ten-eleven-translocation 2 (Tet2)-dependent manner. The CpG motifs of CNS2 in Tregs generated in vitro by TGF-β (iTregs), which were methy…
  • Ascorbic acid efflux from human brain microvascular pericytes: role of re-uptake. [Journal Article]
    Biofactors. 2015 Sep-Oct; 41(5):330-8.May JM, Qu ZC
  • Microvascular pericytes take up ascorbic acid on the ascorbate transporter SVCT2. Intracellular ascorbate then protects the cells against apoptosis induced by culture at diabetic glucose concentrations. To investigate whether pericytes might also provide ascorbate to the underlying endothelial cells, we studied ascorbate efflux from human pericytes. When loaded with ascorbate to intracellular con…
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