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295 results
  • StatPearls [BOOK]
  • BOOKStatPearls Publishing: Treasure Island (FL)
  • Theriot Jonathan J HonorHealth Scottsdale Thompson Peak Medical Center Ashurst John V. JV Kingman Regional Medical Center
  • Select serotonin receptor (5-HT3) antagonists block serotonin both peripherally, on gastrointestinal (GI) vagal nerve terminals, and centrally in the chemoreceptor trigger zone. This results in power...
  • Challenges in implementing and obtaining acceptance for J-Tpeak assessment as the clinical component of CiPA. [Journal Article]
  • JPJ Pharmacol Toxicol Methods 2018 Sep - Oct; 93:75-79
  • Darpo B, Couderc JP
  • CONCLUSIONS: In this limited analysis performed on the IQ-CSRC study waveforms using FDA's automated algorithm, J-Tpeak prolongation was observed on moxifloxacin, but not on dolasetron, despite clinical observations of proarrhythmias with both drugs. Challenges for the implementation of the J-Tpeak interval as a replacement or complement to the QTc interval, include to demonstrate that the proposed clinical algorithm using a J-Tpeak threshold of 10 ms, can be used to categorize drugs with a QT effect up to ~20 ms as having low pro-arrhythmic risk.
  • WITHDRAWN: Drugs for preventing postoperative nausea and vomiting. [Review]
  • CDCochrane Database Syst Rev 2017 07 17; 7:CD004125
  • Carlisle J, Stevenson CA
  • CONCLUSIONS: Either nausea or vomiting is reported to affect, at most, 80 out of 100 people after surgery. If all 100 of these people are given one of the listed drugs, about 28 would benefit and 72 would not. Nausea and vomiting are usually less common and, therefore, drugs are less useful. For 100 people, of whom 30 would vomit or feel sick after surgery if given placebo, 10 people would benefit from a drug and 90 would not. Between one to five patients out of every 100 people may experience a mild side effect, such as sedation or headache, when given an antiemetic drug. Collaborative research should focus on determining whether antiemetic drugs cause more severe, probably rare, side effects. Further comparison of the antiemetic effect of one drug versus another is not a research priority.
  • Percutaneous vertebroplasty under local anaesthesia: feasibility regarding patients' experience. [Journal Article]
  • EREur Radiol 2017; 27(4):1512-1516
  • Bonnard E, Foti P, … Amoretti N
  • CONCLUSIONS: Percutaneous vertebroplasty is feasible under local anaesthesia alone, with a very good or good experience in 76 % of the patients.• Vertebroplasty is a first-line therapy for consolidation and pain control of vertebral lesions. • This procedure is commonly performed under general anaesthesia or conscious sedation. • We perform vertebroplasty under local anaesthesia and simple analgesic protocol with acceptable experience. • Percutaneous vertebroplasty can safely be proposed in a fragile population.
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