- DNMT3A controls miR-200b in cardiac fibroblast autophagy and cardiac fibrosis. [Journal Article]
- IRInflamm Res 2018 May 21
- CONCLUSIONS: Taken together, these findings indicate that DNMT3A regulation of miR-200b controls cardiac fibroblast autophagy during cardiac fibrosis and provide a basis for the development of therapies for cardiac fibrosis.
- Coarctation repair-redo challenges in the adults: what to do? [Review]
- JVJ Vis Surg 2018; 4:76
- Aortic coarctation is one of the most common congenital cardiac pathologies. Repair of native aortic coarctation is nowadays a common and safe procedure. However, late complications, including re-coa...
Aortic coarctation is one of the most common congenital cardiac pathologies. Repair of native aortic coarctation is nowadays a common and safe procedure. However, late complications, including re-coarctation and aneurysm formation, are not uncommon. The incidence of these complications is dependent on the type of the initial operation. Both endovascular and conventional open repair play important roles in the treatment of late complications after previous coarctation repair. This article will review the incidence of late complications after coarctation repair and will discuss the treatment options for redo coarctation repair in adult patients.
- CMR-Based and Time-Shift Corrected Pressure Gradients Provide Good Agreement to Invasive Measurements in Aortic Coarctation. [Letter]
- JCJACC Cardiovasc Imaging 2018 May 11
- Aortic elasticity deterioration proves intrinsic abnormality of the ascending aorta in pediatric Turner syndrome unrelated to the aortic valve morphology. [Journal Article]
- HVHeart Vessels 2018 May 18
- Turner syndrome (TS) is a common genetic disorder in females with high incidence of ascending aortic dilatation and even dissection occurring as early as in the second decade. Known risk factors (RF)...
Turner syndrome (TS) is a common genetic disorder in females with high incidence of ascending aortic dilatation and even dissection occurring as early as in the second decade. Known risk factors (RF) are bicuspid aortic valves (BAV), coarctation of the aorta (CoA), and arterial hypertension. Since 10% of dissections occur in patients without RF, an intrinsic aortic wall abnormality has been postulated. This study aimed to investigate the elasticity of the ascending aorta as a surrogate marker of aortic wall texture. Forty-six pediatric patients with genetically proven TS were prospectively examined for the morphology of their aortic valve, and size and elasticity indices of the adjacent aorta. Cohorts of 46 female subjects with tricuspid aortic valves (TAV) and ten non-syndromic females with BAV were investigated as separate control groups. Comparison of healthy controls with TS patients revealed significantly deteriorated elasticity indices in those with TS. Furthermore, normalized aortic dimensions were greater in TS patients, but dilatations of the ascending aorta with z-score levels above two were restricted to those with BAV (14/46). Deteriorated elasticity indices were measured in TS patients, independent of aortic dilatation, BAV, and CoA, and were comparable to those of patients with isolated, non-syndromic BAVs. By measuring elasticity levels as a surrogate for aortic wall texture, we were able to gather evidence that TS presents with an intrinsic abnormality of the ascending aorta even in patients without concomitant BAV, CoA or dilatations as early as in childhood.
- Custom-made Stent Grafts for the Treatment of Pseudoaneurysms after Childhood Coarctation Surgery. [Journal Article]
- TCThorac Cardiovasc Surg 2018 May 17
- CONCLUSIONS: Redo open surgery is challenging because of adhesions of the thoracic cavity and associated morbidity and mortality. TEVAR is less invasive and offers fewer complications. Custom-made modifications overcome difficult anatomies including short landing zones and diameter variability.
- Turner's syndrome with Severe Coarctation of the Aorta: A Case Report. [Journal Article]
- MMMymensingh Med J 2018; 27(2):417-419
- Cardiovascular abnormalities are frequently encountered in patients with Turner's syndrome. A 12-year-old girl with Turner's syndrome (TS) was referred from the endocrinology department for managemen...
Cardiovascular abnormalities are frequently encountered in patients with Turner's syndrome. A 12-year-old girl with Turner's syndrome (TS) was referred from the endocrinology department for management of hypertension. After Echocardiography and CT angiography, we confirmed that she had severe coarctation of the aorta, just distal to the left subclavian artery. Due to high-pressure gradient in the coarct segment, in presence of hypertension, we made the decision for percutaneous intervention of coarctation of aorta.
- Logical Management of Aortic Coarctation. [Journal Article]
- PPulse (Basel) 2018; 5(1-4):115-116
- Enhanced Aortic Pressure Wave Reflection in Patients with Aortic Coarctation after Aortic Arch Repair. [Review]
- PPulse (Basel) 2018; 5(1-4):82-87
- In patients with aortic coarctation after successful aortic arch repair, it is well known that early-onset cardiovascular diseases can develop.
In patients with aortic coarctation after successful aortic arch repair, it is well known that early-onset cardiovascular diseases can develop.
- Evaluation of a modified Cheatham-Platinum stent for the treatment of aortic coarctation by finite element modelling. [Journal Article]
- JCJRSM Cardiovasc Dis 2018 Jan-Dec; 7:2048004018773958
- CONCLUSIONS: The new design Cheatham-Platinum stent showed similar deployment results compared to the conventional design. The new stent design showed slightly higher expansion, using the same delivery balloon. Patient-specific computational models can be used for virtual implantation of new aortic stents and promise to inform subsequent in vivo trials.
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- Stents in treatment of aortic coarctation and recoarctation in small children. [Editorial]
- IJInt J Cardiol 2018 Jul 15; 263:40-41