- The presence of activating IgG Fc receptors in macrophages aggravates the development of experimental abdominal aortic aneurysm. [Journal Article]Clin Investig Arterioscler. 2023 Feb 01 [Online ahead of print]CI
- CONCLUSIONS: Activation of macrophage FcγR contributes to AAA development by inducing mediators of inflammation, proteolysis, and oxidative stress. Modulation of FcγR or effector molecules may represent a potential target for AAA treatment.
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- Smooth muscle angiotensin II type 1A receptor is required for abdominal aortic aneurysm formation induced by angiotensin II plus β-aminopropionitrile. [Letter]J Mol Cell Cardiol. 2023 Jan 31 [Online ahead of print]JM
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- Pre-Operative Four Dimensional Flow Sensitive Magnetic Resonance Imaging Assessment of Aortic Side Branches as a Method to Predict Risk for Type II Endoleak Resulting in Sac Enlargement After EVAR. [Journal Article]Eur J Vasc Endovasc Surg. 2023 Jan 31 [Online ahead of print]EJ
- CONCLUSIONS: Pre-EVAR haemodynamic analyses using 4D flow MRI were useful to detect aortic branches responsible for ELII and to predict AAA cases with sac enlargement. This analysis suggests a new strategy for pre-EVAR aortic branch embolisation.
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- [A Resected Case of the Sigmoid Colon Cancer after the Endovascular Aneurysm Repair in Which Intraoperative Indocyanine Green Fluorescence Method Was Useful for Evaluating the Blood Flow in the Colon]. [Journal Article]Gan To Kagaku Ryoho. 2022 Dec; 49(13):1637-1639.GT
- A man in his 70s underwent an endovascular aneurysm repair(EVAR)for abdominal aortic aneurysm. Blood test revealed an anemia and an increased tumor marker. Enhanced computed tomography revealed the wall thickening in the sigmoid colon and the Type Ⅱ endoleak after EVAR. Colonoscopy showed the wall thickening in the sigmoid colon, and biopsy indicated a diagnosis of adenocarcinoma. We performed op…
- Strategies for endoleak treatment after endovascular abdominal aortic aneurysm repair: A single center retrospective study. [Journal Article]Asian J Surg. 2023 Jan 31 [Online ahead of print]AJ
- CONCLUSIONS: Endoleak after EVAR is the most frequent complication that directly affects survival and re-intervention rates. Our findings suggested that different treatment strategies based on the individual patient's situation is important for their endoleak treating result.
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- Patient Selection and Risk Stratification in Abdominal Aortic Aneurysm Repair: First Do No Harm. [Journal Article]Eur J Vasc Endovasc Surg. 2023 Jan 30 [Online ahead of print]EJ
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- Midterm Outcomes of Antegrade In Situ Laser Fenestration of Polyester Endografts for Urgent Treatment of Aortic Pathologies Involving Visceral and Renal Arteries. [Journal Article]Eur J Vasc Endovasc Surg. 2023 Jan 30 [Online ahead of print]EJ
- CONCLUSIONS: Antegrade LFEVAR is feasible, safe, and provides satisfactory early and midterm outcomes for non-deferrable treatment of aortic pathologies involving the visceral segment. Long term data are mandatory to confirm the usefulness of this promising off label technique.
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- Scale down and optimized automated production of [68Ga]68Ga-DOTA-ECL1i PET tracer targeting CCR2 expression. [Journal Article]EJNMMI Radiopharm Chem. 2023 Feb 02; 8(1):3.ER
- CONCLUSIONS: [68Ga]68Ga-DOTA-ECL1i was successfully synthesized and it is, thus, available for multi-dose application in clinical settings.
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- Use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers increases the risk of postoperative acute kidney injury after elective endovascular abdominal aortic aneurysm repair. [Journal Article]Chin Med J (Engl). 2023 Jan 03 [Online ahead of print]CM
- CONCLUSIONS: Postoperative AKI was associated with lower survival rate, and the use of ACEIs/ARBs was the only adjustable independent risk factor. Clinicians should consider withdrawing ACEIs/ARBs in high-risk patients undergoing elective endovascular abdominal aortic aneurysm repair to prevent postoperative AKI.
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- Gender Influence on Abdominal Aortic Aneurysm Surgery in a Caribbean Population. [Journal Article]
- Female patients with abdominal aortic aneurysms (AAAs) are usually less common and older than their male counterparts. We report on AAA disease in a Caribbean nation with respect to gender and review their outcomes relative to the male population. Data were collected prospectively and analyzed retrospectively for patients with AAAs who underwent surgery from 2001 to 2018. Sixty patients were diag…
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- A Comprehensive Research Schema for the Characterization of Aortic Aneurysms. [Journal Article]
- A robust, accurate, and standardized approach to measurement of the aorta is critical to improve the predictive accuracy of these aortic measurements, and to investigate other aortic imaging biomarkers. Developing a comprehensive and generic schema for characterization of the aorta to enable investigators to standardize data that are collected across all aorta research. A systematic review of the…
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- Tricaprin can prevent the development of AAA by attenuating aortic degeneration. [Journal Article]Biomed Pharmacother. 2023 Jan 30; 160:114299.BP
- Medical therapeutic options to prevent rupture of abdominal aortic aneurysm (AAA), a critical event, must be developed. Moreover, further understanding of the process of AAA development and rupture is crucial. Previous studies have revealed that aortic hypoperfusion can induce the development of AAA, and we successfully developed a hypoperfusion-induced AAA animal model. In this study, we examine…
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- How does hemodynamics affect rupture tissue mechanics in abdominal aortic aneurysm: Focus on wall shear stress derived parameters, time-averaged wall shear stress, oscillatory shear index, endothelial cell activation potential, and relative residence time. [Review]Comput Biol Med. 2023 Jan 23; 154:106609.CB
- An abdominal aortic aneurysm (AAA) is a critical health condition with a risk of rupture, where the diameter of the aorta enlarges more than 50% of its normal diameter. The incidence rate of AAA has increased worldwide. Currently, about three out of every 100,000 people have aortic diseases. The diameter and geometry of AAAs influence the hemodynamic forces exerted on the arterial wall. Therefore…
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- Sex-specific differences in the standard of care for infrarenal abdominal aortic aneurysm repair, and risk of major adverse cardiovascular events and death. [Journal Article]Br J Surg. 2023 Jan 31 [Online ahead of print]BJ
- CONCLUSIONS: SOC waiting times and preoperative assessment were not met for both sexes, which was associated with an increased risk of MACED. Sex-specific differences in SOC attenuated but did not fully account for the increased risk of MACED in women.
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- Shared Decision Making in and Management of Intact Abdominal Aortic Aneurysm: A Scoping Review of the Literature. [Review]Eur J Vasc Endovasc Surg. 2023 Jan 28 [Online ahead of print]EJ
- CONCLUSIONS: SDM for patients with intact AAAs appears to be in its infancy. Most patients with AAAs desire SDM, but this is not commonly applied. Most patients with AAA do not receive adequate information for SDM, although the use of bespoke DSTs leaves patients better informed to facilitate SDM.
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- Abdominal aortic aneurysm growth rates are not correlated to body surface area in screened men. [Journal Article]Int Angiol. 2023 Jan 31 [Online ahead of print]IA
- CONCLUSIONS: Body surface area could not be found to have a statistically significant correlation to AAA growth rates. The impact of smoking and diabetes on AAA growth rates remains similar to previously reported.
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- Angiotensin II Type 1 Receptor Blocker Prevents Abdominal Aortic Aneurysm Progression in Osteoprotegerin-Deficient Mice via Upregulation of Angiotensin (1-7). [Journal Article]J Am Heart Assoc. 2023 Jan 31 [Online ahead of print]JA
- Background Angiotensin II type 1 receptor blockers (ARBs) have been shown to limit the growth of abdominal aortic aneurysm (AAA), but their efficacy is controversial. This study aimed to investigate the molecular mechanism underlying the protective effect of ARBs against AAA progression. Methods and Results Olmesartan, an ARB, was administered to wild-type and osteoprotegerin-knockout (Opg-KO) mi…
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- Open Surgery for Abdominal Aortic Aneurysm: 980 Consecutive Patient Outcomes from a High-Volume Centre in the United Kingdom. [Journal Article]Vasc Endovascular Surg. 2023 Jan 30 [Online ahead of print]VE
- CONCLUSIONS: Our data confirm that open surgery for AAA can be performed in large volume centres quite safely. Elective and Emergency surgery does affect early 30 day mortality but does not influence long-term outcome.
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- INKILN is a novel long noncoding RNA promoting vascular smooth muscle inflammation via scaffolding MKL1 and USP10. [Preprint]bioRxiv. 2023 Jan 09B
- CONCLUSIONS: These findings elucidate an important pathway of VSMC inflammation involving an INKILN /MKL1/USP10 regulatory axis. Human BAC Tg mice offer a novel and physiologically relevant approach for investigating human-specific lncRNAs under vascular disease conditions.
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- Hyperuricemia exacerbates abdominal aortic aneurysm formation through the URAT1/ERK/MMP-9 signaling pathway. [Journal Article]
- CONCLUSIONS: We have provided human evidence that hyperuricemia exacerbates AAA formation. In addition, our murine experimental evidence suggests that hyperuricemia exacerbates AAA formation and reveals that the URAT1/ERK1/2/ROS/MMP-9 pathway is among the pathways activated by uric acid in HASMCs.
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- The Impact of a Limited Field-of-View on Computed Hemodynamics in Abdominal Aortic Aneurysms: Evaluating the Feasibility of Completing Ultrasound Segmentations with Parametric Geometries. [Journal Article]Ann Biomed Eng. 2023 Jan 28 [Online ahead of print]AB
- To improve abdominal aortic aneurysm (AAA) rupture risk assessment, a large, longitudinal study on AAA hemodynamics and biomechanics is necessary, using personalized fluid-structure interaction (FSI) modeling. 3-dimensional, time-resolved ultrasound (3D+t US) is the preferred image modality to obtain the patient-specific AAA geometry for such a study, since it is safe, affordable and provides tem…
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- Interleukin-38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2-p38 pathway-dependent manner. [Journal Article]
- Macrophages play crucial roles in abdominal aortic aneurysm (AAA) formation through the inflammatory response and extracellular matrix degradation; therefore, regulating macrophages may suppress AAA formation. Interleukin-38 (IL-38) is a member of the IL-1 family, which binds to IL-36 receptor (IL1RL2) and has an anti-inflammation effect. Because macrophages express IL1RL2, we hypothesized that I…
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- Effect of rheological models on pulsatile hemodynamics in a multiply afflicted descending human aortic network. [Journal Article]Comput Methods Biomech Biomed Engin. 2023 Jan 28 [Online ahead of print]CM
- In the cardiovascular diseased (CVD) conditions, it is essential to choose a suitable rheological model for capturing the correct physics behind the hemodynamic in the multiply afflicted diseased arterial network. This study investigates the effect of blood rheology on hemodynamics in a blood vessel with abdominal aortic aneurysm (AAA) and right internal iliac stenosis (RIIAS). A model with AAA a…
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- Unique case of abdominal aortic aneurysm causing obstructive jaundice and duodenal obstruction. [Journal Article]J R Coll Physicians Edinb. 2023 Jan 28 [Online ahead of print]JR
- Obstruction of the duodenum by an abdominal aortic aneurysm (AAA) (aortoduodenal syndrome) has rarely been reported. It presents with symptoms of upper gastrointestinal (GI) tract obstruction. Obstructive jaundice caused by an AAA is also extremely rare and requires high clinical suspicion. We present a unique case with informed consent of an elderly gentleman who presented with both rare present…
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- Additional Aortic Coverage With Off The Shelf, Multibranched Endograft Compared With Custom-Made Devices For Endovascular Repair of Pararenal Abdominal Aortic Aneurysm. [Journal Article]Eur J Vasc Endovasc Surg. 2023 Jan 24 [Online ahead of print]EJ
- CONCLUSIONS: Despite not requiring customisation time, OTS endografts for the treatment of p-AAA lead to a more extensive healthy aortic coverage, as well as an average sacrifice of 2.5 additional segmental arteries, in comparison with CMDs. When compared with OTS devices, CMDs appear to limit the extent of unnecessary aortic coverage and the theoretical subsequent risk of spinal cord ischaemia.
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- Use of Secondary Iliac Branch Devices after Previous Endovascular Abdominal and Thoraco-Abdominal Aortic Aneurysm Repair†. [Journal Article]Eur J Vasc Endovasc Surg. 2023 Jan 24 [Online ahead of print]EJ
- CONCLUSIONS: Secondary IBD after EVAR is a safe and effective procedure with high technical success and low complication rates. The technique of choice to revascularise the IIA seems to not affect early and follow up results. Long term durability of IBD repair is acceptable with low rates of IIA re-interventions.
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- Macrophage elastase derived from adventitial macrophages modulates aortic remodeling. [Journal Article]
- Abdominal aortic aneurysm (AAA) is pathologically characterized by intimal atherosclerosis, disruption and attenuation of the elastic media, and adventitial inflammatory infiltrates. Although all these pathological events are possibly involved in the pathogenesis of AAA, the functional roles contributed by adventitial inflammatory macrophages have not been fully documented. Recent studies have re…
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- Effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repair. [Journal Article]
- Introduction: Chronic heart disease (CHD) is a common comorbidity of patients receiving endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA). The explicit relationship between ventricular systolic function and EVAR complication of thrombotic events is unknown. Methods: In this study, we proposed a three-dimensional numerical model coupled with the lumped-elements heart model, …
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- Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level. [Journal Article]
- Introduction: Aortic aneurysm is a life-threatening disease resulted from progressive dilatation of the aorta, which can be subdivided into thoracic and abdominal aortic aneurysms. Sustained subcutaneous angiotensin II infusion can induce aortic aneurysms in mice. However, the relevance of using angiotensin II induction model to study aneurysm disease and the degree of commonality between species…
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- The impact of race on outcomes following ruptured abdominal aortic aneurysm repair. [Journal Article]J Vasc Surg. 2023 Jan 23 [Online ahead of print]JV
- CONCLUSIONS: This study identified racial differences in demographic, clinical, and procedural characteristics for patients undergoing rAAA repair. In particular, the door-to-intervention time for Black patients of 2.8 hours does not meet the Society for Vascular Surgery recommendation of 90 minutes. Despite these differences, 8-year mortality is similar for Black and White patients. These differences should be further investigated and there are opportunities to improve rAAA care for Black patients.
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