- [Conversion Surgery for Stage Ⅳ Gastric Cancer with Liver Metastases after Second-Line Chemotherapy(Ramucirumab/Paclitaxel)-A Case Report]. [Journal Article]Gan To Kagaku Ryoho. 2022 Dec; 49(13):1905-1907.GT
- A 78-year-old man was diagnosed with a liver tumor on follow-up CT after thoracic aortic aneurysm surgery. Esophagogastroduodenoscopy revealed a type 2 tumor in the gastric antrum, a biopsy showed poorly differentiated adenocarcinoma, and CT revealed multiple liver metastases, resulting in a diagnosis of clinical Stage ⅣB(cT4aN0M1[HEP]). S-1/oxaliplatin (SOX)chemotherapy was started. However, aft…
- Treatment of infected thoracic aortic aneurysm with combined abscess debridement and stent-graft wrapping using pedicled latissimus dorsi muscle flaps after thoracic endovascular aortic repair. [Journal Article]J Cardiothorac Surg. 2023 Feb 02; 18(1):57.JC
- CONCLUSIONS: A combined abscess debridement and pedicled tissue flap approach is useful for patients with poor surgical tolerance in whom infection control is difficult after thoracic endovascular aortic repair for infected thoracic aortic aneurysms. Pedicled latissimus dorsi muscle flaps are useful when using the omentum for pedicled tissue flap is difficult.
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- [Staged Hybrid Repair of Extensive Thoracic Aortic Aneurysm with Right Aortic Arch and Isolated Left Subclavian Artery:Report of a Case]. [Journal Article]Kyobu Geka. 2023 Feb; 76(2):132-135.KG
- A 69-year-old male was referred to our hospital due to extensive thoracic aortic aneurysm with right aortic arch and isolated left subclavian artery. We chose staged hybrid repair to avoid the risk of spinal cord injury and bilateral recurrent nerve paralysis. First, ascending aorta replacement with elephant trunk and reconstruction of the cervical branches were underwent. Second, we performed th…
- Comparison of single and multistage strategies during fenestrated-branched endovascular aortic repair of thoracoabdominal aortic aneurysms. [Journal Article]J Vasc Surg. 2023 Jan 30 [Online ahead of print]JV
- CONCLUSIONS: Staging elective FB-EVAR of Extent I to III TAAAs was associated with decreased risk of mortality and/or permanent paraplegia at 30-days or within hospital stay, and with higher patient survival at 1- and 3-years.
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- Cordycepin suppresses vascular inflammation, apoptosis and oxidative stress of arterial smooth muscle cell in thoracic aortic aneurysm with VEGF inhibition. [Journal Article]Int Immunopharmacol. 2023 Jan 31; 116:109759.II
- CONCLUSIONS: Cordycepin inhibited apoptosis, inflammation and oxidative stress of TAA through the inhibition of VEGF.
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- A Comprehensive Research Schema for the Characterization of Aortic Aneurysms. [Journal Article]
- A robust, accurate, and standardized approach to measurement of the aorta is critical to improve the predictive accuracy of these aortic measurements, and to investigate other aortic imaging biomarkers. Developing a comprehensive and generic schema for characterization of the aorta to enable investigators to standardize data that are collected across all aorta research. A systematic review of the…
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- Williams-Beuren syndrome with pseudoaneurysm of aortic arch and infective vegetations for modified broms procedure: anesthetic concerns & Echocardiographic illustrations. [Case Reports]Ann Card Anaesth. 2023 Jan-Mar; 26(1):94-96.AC
- Williams-Beuren syndrome is a rare genetic malformation with predilection for supravalvular aortic stenosis. Apart from cardiovascular malformation, hypocalcemia, developmental delay, and elfin facies, challenging airway make perioperative management more eventful. Association of infective endocarditis within the aortic arch and pseudoaneurysm formation is infrequent. We, hereby report a case of …
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- Shared Decision Making in and Management of Intact Abdominal Aortic Aneurysm: A Scoping Review of the Literature. [Review]Eur J Vasc Endovasc Surg. 2023 Jan 28 [Online ahead of print]EJ
- CONCLUSIONS: SDM for patients with intact AAAs appears to be in its infancy. Most patients with AAAs desire SDM, but this is not commonly applied. Most patients with AAA do not receive adequate information for SDM, although the use of bespoke DSTs leaves patients better informed to facilitate SDM.
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- A Mouse Model of Spinal Cord Hypoperfusion with Immediate Paralysis Caused by Endovascular Repair of Thoracic Aortic Aneurysm. [Journal Article]Anesthesiology. 2023 Jan 30 [Online ahead of print]A
- CONCLUSIONS: Our mouse model generates reproducible spinal cord hypoperfusion and accompanying histopathological ischemic spinal cord damage. The resulting anatomical changes and variable behavioral deficits mimic the variability in radiological and clinical findings in human patients.
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- Circulatory Arrest for Traumatic Brachiocephalic Artery Pseudoaneurysm Repair. [Journal Article]Tex Heart Inst J. 2023 Jan 01; 50(1)TH
- Blunt traumatic injuries to the brachiocephalic artery require surgical management. The operative technique used depends on the location of the injury, the patient's hemodynamic stability, and the surgeon's experience. Perfusion strategy can facilitate vascular control of the aortic arch and branch vessels. This report presents an urgent repair of a proximal posterior blunt traumatic brachiocepha…
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- Risk for acquired coronary artery disease in genetic vs. congenital thoracic aortopathy. [Journal Article]
- CONCLUSIONS: Marfan syndrome and bicuspid aortic valve patients have a significantly lower risk for, and prevalence of CAD as compared to TAV individuals.
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- Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level. [Journal Article]
- Introduction: Aortic aneurysm is a life-threatening disease resulted from progressive dilatation of the aorta, which can be subdivided into thoracic and abdominal aortic aneurysms. Sustained subcutaneous angiotensin II infusion can induce aortic aneurysms in mice. However, the relevance of using angiotensin II induction model to study aneurysm disease and the degree of commonality between species…
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- Are acute type A aortic dissections atherosclerotic? [Journal Article]Front Cardiovasc Med. 2022; 9:1032755.FC
- Type A aortic dissections (TAAD) are devastating aortic complications. Patients with Marfan syndrome, a bicuspid aortic valve or a thoracic aortic aneurysm have an increased risk to develop a TAAD. These predisposing conditions are characterized by a histologically thin intimal layer and hardly any atherosclerosis. Little is known about the susceptibility for atherosclerosis in patients with a ty…
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- Motor-evoked potentials monitoring with remimazolam during thoracic descending aortic aneurysm surgery: a case report. [Journal Article]J Anesth. 2023 Jan 25 [Online ahead of print]JA
- Paraplegia remains the most devastating complication following thoracoabdominal aortic surgery. Motor-evoked potential (MEP) monitoring has been widely used to assess intraoperative motor function. MEP amplitude is affected by various factors, including anesthetic agents and measurement time; however, there are no reports regarding MEP monitoring using remimazolam in thoracoabdominal aortic surge…
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- Lower Body Perfusion Reduces the Morbidity of Postoperative Acute Kidney Injury in Type A Dissection: A Propensity-Matched Analysis. [Journal Article]Braz J Cardiovasc Surg. 2023 Jan 20 [Online ahead of print]BJ
- CONCLUSIONS: LBP resulted as a safe and feasible approach in aortic arch surgery, as it could significantly shorten the circulatory arrest time, which might reduce the incidence of postoperative level I acute kidney injury.
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- Prevalence and development of aortic dilation and dissection in women with Turner syndrome: a systematic review and meta-analysis. [Journal Article]Expert Rev Cardiovasc Ther. 2023 Jan 30 [Online ahead of print]ER
- CONCLUSIONS: In adult TS women, ascending aortic dilatation is common and the hazard of aortic dissection increased compared to the general population, whereas aortic growth is limited. Conventional risk markers do not explain all aortic dissection cases; therefore, new imaging parameters and blood biomarkers are needed to improve prediction, allowing for patient-tailored follow-up and surgical decision-making.
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- Iliac Branch Devices in the Repair of Ruptured Aorto-iliac Aneurysms: A Multicenter Study. [Journal Article]J Endovasc Ther. 2023 Jan 22 [Online ahead of print]JE
- CONCLUSIONS: This multicenter study demonstrates that ruptured aortoiliac aneurysms do not necessarily require mandatory occlusion of hypogastric arteries. Iliac branch devices are shown to be a valid alternative in highly selected cases, with good midterm results, even if reinterventions are required in a significant proportion of patients.
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- Intermediate outcomes following arch reconstruction with frozen elephant trunk, a single centre study. [Journal Article]
- CONCLUSIONS: Postoperative dialysis was found to be a predictor of in-hospital mortality, while both dialysis as well as reoperation due to bleeding and/or visceral ischemia increased the risk for overall mortality, irrespective of preoperative diagnosis. Previous or current smoking appeared to be associated with negative outcomes regarding both in-hospital and overall mortality during follow-up. Trial registration Retrospectively enrolled.
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- Prevalence and Risk Factors of Abdominal Aortic Aneurysms Detected with Ultrasound in Korea and Belgium. [Journal Article]
- The objective was to investigate the prevalence of abdominal aortic aneurysms (AAAs) and the diameters of the aorta and common iliac arteries (CIAs) in a Korean cohort and secondly to analyze the differences in aortic diameter by comparison with a European cohort. The Korean cohort included participants ≥ 50 years who consented to AAA screening and data were analysed retrospectively. Aortic and c…
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- Comparison of In-Vivo and Ex-Vivo Ascending Aorta Elastic Properties through Automatic Deep Learning Segmentation of Cine-MRI and Biomechanical Testing. [Journal Article]
- Ascending aortic aneurysm is a pathology that is important to be supervised and treated. During the years the aorta dilates, it becomes stiff, and its elastic properties decrease. In some cases, the aortic wall can rupture leading to aortic dissection with a high mortality rate. The main reference standard to measure when the patient needs to undertake surgery is the aortic diameter. However, the…
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- Molecular Mechanisms in Genetic Aortopathy-Signaling Pathways and Potential Interventions. [Review]
- Thoracic aortic disease affects people of all ages and the majority of those aged <60 years have an underlying genetic cause. There is presently no effective medical therapy for thoracic aneurysm and surgery remains the principal intervention. Unlike abdominal aortic aneurysm, for which the inflammatory/atherosclerotic pathogenesis is well established, the mechanism of thoracic aneurysm is less u…
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- Molecular and Cellular Mechanisms Involved in Aortic Wall Aneurysm Development. [Review]
- Aortic aneurysms represent a very common pathology that can affect any segment of the aorta. These types of aneurysms can be localized on the thoracic segment or on the abdominal portion, with the latter being more frequent. Though there are similarities between thoracic and abdominal aortic aneurysms, these pathologies are distinct entities. In this article, we undertook a review regarding the d…
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- Subthalamic Nucleus Deep Brain Stimulation Treats Parkinson's Disease Patients with Cardiovascular Disease Comorbidity: A Retrospective Study of a Single Center Experience. [Journal Article]
- CONCLUSIONS: STN-DBS under general anesthesia is safe and effective for treating PD patients with CVD comorbidity. Our clinical experience and protocol of the MDT offers comprehensive perioperative evaluation for DBS surgery and mitigates bleeding and cardiovascular-associated events in PD patients with CVD comorbidity.
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- Fluid-structure interaction simulation of visceral perfusion and impact of different cannulation methods on aortic dissection. [Journal Article]
- Hemodynamics in aortic dissection (AD) is closely associated with the risk of aortic aneurysm, rupture, and malperfusion. Altered blood flow in patients with AD can lead to severe complications such as visceral malperfusion. In this study, we aimed to investigate the effect of cannulation flow on hemodynamics in AD using a fluid-structure interaction simulation. We developed a specific-idealized …
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- A phenotypic screen of Marfan syndrome iPSC-derived vascular smooth muscle cells uncovers GSK3β as a new target. [Journal Article]Stem Cell Reports. 2022 Dec 30 [Online ahead of print]SC
- Marfan syndrome (MFS) is a rare connective tissue disorder caused by mutations in FBN1. Patients with MFS notably suffer from aortic aneurysm and dissection. Despite considerable effort, animal models have proven to be poorly predictive for therapeutic intervention in human aortic disease. Patient-derived induced pluripotent stem cells can be differentiated into vascular smooth muscle cells (VSMC…
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- ADAMTS-7 deficiency attenuates thoracic aortic aneurysm and dissection in mice. [Journal Article]J Mol Med (Berl). 2023 Jan 20 [Online ahead of print]JM
- Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening cardiovascular disease with severe extracellular matrix (ECM) remodeling that lacks efficient early stage diagnosis and nonsurgical therapy. A disintegrin and metalloproteinase with thrombospondin motif 7 (ADAMTS-7) is recognized as a novel locus for human coronary artery atherosclerosis. Previous work by us and others showed th…
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- Augmentation Index in Patients with Thoracic Aortic Aneurysm: A Matched Case-Control Study. [Journal Article]
- Thoracic aortic aneurysms (TAA) may be associated with complications such as rupture and dissection, which can lead to a fatal outcome. Increased central arterial stiffness has been proposed to be present in patients with TAA compared to unmatched controls. We aimed to assess whether wall properties in patients with TAA are also altered when compared to a matched control group. Applanation tonome…
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- Preparing the spinal cord - priming or preconditioning? A systematic review of experimental studies. [Review]Scand Cardiovasc J. 2023 12; 57(1):2166100.SC
- Objectives. Paraplegia is devastating complication associated with thoracic and thoracoabdominal aortic aneurysm repair. Vast evidence has been gathered on pre-, peri- and postoperative protective adjuncts aiming to minimize spinal cord ischemia. This review focuses on the pretreatment phase of open surgical or endovascular aortic procedures and gathers the experimental data on the interventional…
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- Uncorrected Preoperative Infection Causing the Death of a Patient with a Thoracic Aortic Aneurysm. [Case Reports]
- CONCLUSIONS: Given that this patient with a TAA rupture died of uncorrected acidosis caused by preoperative infection, it is important to evoke the diagnosis in the context of TAA. Routine laboratory indicators are valuable factors for surgeons and physicians in assessing a patient's condition and improving their prognosis.
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